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Gene: TCF7 |
Gene summary for TCF7 |
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Gene information | Species | Human | Gene symbol | TCF7 | Gene ID | 6932 |
Gene name | transcription factor 7 | |
Gene Alias | TCF-1 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P36402 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6932 | TCF7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.21e-03 | 3.11e-01 | -0.0811 |
6932 | TCF7 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.42e-02 | 1.81e-01 | -0.1464 |
6932 | TCF7 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.46e-04 | 2.80e-01 | 0.096 |
6932 | TCF7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.17e-05 | 2.56e-01 | 0.0674 |
6932 | TCF7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.47e-27 | 8.19e-01 | 0.3859 |
6932 | TCF7 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.34e-12 | 6.41e-01 | 0.2585 |
6932 | TCF7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.93e-20 | 5.40e-01 | 0.3005 |
6932 | TCF7 | S43 | Human | Liver | Cirrhotic | 3.14e-02 | -1.41e-01 | -0.0187 |
6932 | TCF7 | HCC1_Meng | Human | Liver | HCC | 2.48e-13 | -1.54e-01 | 0.0246 |
6932 | TCF7 | HCC2_Meng | Human | Liver | HCC | 5.22e-12 | -7.61e-02 | 0.0107 |
6932 | TCF7 | HCC1 | Human | Liver | HCC | 9.59e-03 | 3.01e+00 | 0.5336 |
6932 | TCF7 | S014 | Human | Liver | HCC | 3.18e-12 | 7.11e-01 | 0.2254 |
6932 | TCF7 | S015 | Human | Liver | HCC | 9.32e-10 | 6.73e-01 | 0.2375 |
6932 | TCF7 | S016 | Human | Liver | HCC | 8.72e-11 | 6.83e-01 | 0.2243 |
6932 | TCF7 | C21 | Human | Oral cavity | OSCC | 4.01e-06 | 1.80e-01 | 0.2678 |
6932 | TCF7 | C30 | Human | Oral cavity | OSCC | 2.40e-06 | 3.87e-01 | 0.3055 |
6932 | TCF7 | C43 | Human | Oral cavity | OSCC | 1.05e-13 | 3.78e-01 | 0.1704 |
6932 | TCF7 | C46 | Human | Oral cavity | OSCC | 1.63e-09 | 2.47e-01 | 0.1673 |
6932 | TCF7 | C06 | Human | Oral cavity | OSCC | 2.77e-06 | 7.68e-01 | 0.2699 |
6932 | TCF7 | C08 | Human | Oral cavity | OSCC | 7.11e-08 | 2.41e-01 | 0.1919 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00330023 | Prostate | BPH | muscle cell proliferation | 61/3107 | 248/18723 | 7.61e-04 | 5.02e-03 | 61 |
GO:00486605 | Prostate | BPH | regulation of smooth muscle cell proliferation | 47/3107 | 180/18723 | 7.63e-04 | 5.03e-03 | 47 |
GO:00486595 | Prostate | BPH | smooth muscle cell proliferation | 47/3107 | 184/18723 | 1.26e-03 | 7.62e-03 | 47 |
GO:19040353 | Prostate | BPH | regulation of epithelial cell apoptotic process | 28/3107 | 96/18723 | 1.46e-03 | 8.69e-03 | 28 |
GO:0010717 | Prostate | BPH | regulation of epithelial to mesenchymal transition | 28/3107 | 99/18723 | 2.42e-03 | 1.31e-02 | 28 |
GO:00301786 | Prostate | BPH | negative regulation of Wnt signaling pathway | 43/3107 | 170/18723 | 2.42e-03 | 1.31e-02 | 43 |
GO:00716928 | Prostate | BPH | protein localization to extracellular region | 82/3107 | 368/18723 | 2.59e-03 | 1.39e-02 | 82 |
GO:005071410 | Prostate | BPH | positive regulation of protein secretion | 36/3107 | 137/18723 | 2.64e-03 | 1.41e-02 | 36 |
GO:00093069 | Prostate | BPH | protein secretion | 80/3107 | 359/18723 | 2.89e-03 | 1.52e-02 | 80 |
GO:00355929 | Prostate | BPH | establishment of protein localization to extracellular region | 80/3107 | 360/18723 | 3.13e-03 | 1.63e-02 | 80 |
GO:00107182 | Prostate | BPH | positive regulation of epithelial to mesenchymal transition | 17/3107 | 52/18723 | 3.30e-03 | 1.71e-02 | 17 |
GO:00507088 | Prostate | BPH | regulation of protein secretion | 62/3107 | 268/18723 | 3.35e-03 | 1.73e-02 | 62 |
GO:00468278 | Prostate | BPH | positive regulation of protein export from nucleus | 8/3107 | 17/18723 | 3.36e-03 | 1.73e-02 | 8 |
GO:00454452 | Prostate | BPH | myoblast differentiation | 24/3107 | 84/18723 | 4.13e-03 | 2.04e-02 | 24 |
GO:00900903 | Prostate | BPH | negative regulation of canonical Wnt signaling pathway | 35/3107 | 137/18723 | 4.90e-03 | 2.32e-02 | 35 |
GO:004259315 | Prostate | BPH | glucose homeostasis | 59/3107 | 258/18723 | 5.38e-03 | 2.50e-02 | 59 |
GO:003350015 | Prostate | BPH | carbohydrate homeostasis | 59/3107 | 259/18723 | 5.86e-03 | 2.72e-02 | 59 |
GO:19035324 | Prostate | BPH | positive regulation of secretion by cell | 62/3107 | 282/18723 | 1.07e-02 | 4.45e-02 | 62 |
GO:200123319 | Prostate | Tumor | regulation of apoptotic signaling pathway | 137/3246 | 356/18723 | 1.01e-21 | 1.25e-18 | 137 |
GO:005109819 | Prostate | Tumor | regulation of binding | 122/3246 | 363/18723 | 2.86e-14 | 3.63e-12 | 122 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa05213 | Colorectum | AD | Endometrial cancer | 29/2092 | 58/8465 | 2.69e-05 | 2.57e-04 | 1.64e-04 | 29 |
hsa05216 | Colorectum | AD | Thyroid cancer | 21/2092 | 37/8465 | 3.05e-05 | 2.76e-04 | 1.76e-04 | 21 |
hsa05210 | Colorectum | AD | Colorectal cancer | 35/2092 | 86/8465 | 7.54e-04 | 5.49e-03 | 3.50e-03 | 35 |
hsa05225 | Colorectum | AD | Hepatocellular carcinoma | 59/2092 | 168/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 59 |
hsa05215 | Colorectum | AD | Prostate cancer | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa04310 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa052131 | Colorectum | AD | Endometrial cancer | 29/2092 | 58/8465 | 2.69e-05 | 2.57e-04 | 1.64e-04 | 29 |
hsa052161 | Colorectum | AD | Thyroid cancer | 21/2092 | 37/8465 | 3.05e-05 | 2.76e-04 | 1.76e-04 | 21 |
hsa052101 | Colorectum | AD | Colorectal cancer | 35/2092 | 86/8465 | 7.54e-04 | 5.49e-03 | 3.50e-03 | 35 |
hsa052251 | Colorectum | AD | Hepatocellular carcinoma | 59/2092 | 168/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 59 |
hsa052151 | Colorectum | AD | Prostate cancer | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa043101 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa051324 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa045204 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa052162 | Colorectum | MSS | Thyroid cancer | 21/1875 | 37/8465 | 4.98e-06 | 6.00e-05 | 3.68e-05 | 21 |
hsa052102 | Colorectum | MSS | Colorectal cancer | 36/1875 | 86/8465 | 3.08e-05 | 3.22e-04 | 1.97e-04 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCF7 | SNV | Missense_Mutation | c.379N>A | p.Leu127Met | p.L127M | P36402 | protein_coding | tolerated(0.27) | probably_damaging(0.991) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TCF7 | insertion | Frame_Shift_Ins | rs771602751 | c.456_457insC | p.His155ProfsTer37 | p.H155Pfs*37 | P36402 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
TCF7 | insertion | Frame_Shift_Ins | rs771602751 | c.456_457insC | p.His155ProfsTer37 | p.H155Pfs*37 | P36402 | protein_coding | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TCF7 | SNV | Missense_Mutation | rs766182177 | c.1043G>A | p.Arg348Gln | p.R348Q | P36402 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TCF7 | SNV | Missense_Mutation | rs775076567 | c.490N>A | p.Glu164Lys | p.E164K | P36402 | protein_coding | deleterious(0.03) | benign(0.049) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TCF7 | SNV | Missense_Mutation | novel | c.854C>T | p.Ala285Val | p.A285V | P36402 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TCF7 | SNV | Missense_Mutation | c.1016N>A | p.Arg339Gln | p.R339Q | P36402 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TCF7 | SNV | Missense_Mutation | rs775076567 | c.490G>A | p.Glu164Lys | p.E164K | P36402 | protein_coding | deleterious(0.03) | benign(0.049) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TCF7 | SNV | Missense_Mutation | novel | c.810G>T | p.Lys270Asn | p.K270N | P36402 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TCF7 | SNV | Missense_Mutation | novel | c.601N>T | p.Gly201Cys | p.G201C | P36402 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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