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Gene: CD2 |
Gene summary for CD2 |
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Gene information | Species | Human | Gene symbol | CD2 | Gene ID | 914 |
Gene name | CD2 molecule | |
Gene Alias | LFA-2 | |
Cytomap | 1p13.1 | |
Gene Type | protein-coding | GO ID | GO:0001766 | UniProtAcc | P06729 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
914 | CD2 | GSM4909317 | Human | Breast | IDC | 5.23e-05 | 1.70e-01 | 0.1355 |
914 | CD2 | M1 | Human | Breast | IDC | 3.01e-40 | 8.10e-01 | 0.1577 |
914 | CD2 | P1 | Human | Breast | IDC | 4.16e-12 | 6.08e-01 | 0.1527 |
914 | CD2 | LZE4T | Human | Esophagus | ESCC | 4.60e-14 | 7.29e-01 | 0.0811 |
914 | CD2 | LZE7T | Human | Esophagus | ESCC | 2.24e-10 | 7.96e-01 | 0.0667 |
914 | CD2 | LZE8T | Human | Esophagus | ESCC | 3.62e-04 | 4.38e-01 | 0.067 |
914 | CD2 | LZE22D1 | Human | Esophagus | HGIN | 3.59e-02 | 2.59e-01 | 0.0595 |
914 | CD2 | LZE24T | Human | Esophagus | ESCC | 4.59e-03 | 1.77e-01 | 0.0596 |
914 | CD2 | LZE6T | Human | Esophagus | ESCC | 3.15e-24 | 1.50e+00 | 0.0845 |
914 | CD2 | C21 | Human | Oral cavity | OSCC | 1.93e-15 | 6.64e-01 | 0.2678 |
914 | CD2 | C30 | Human | Oral cavity | OSCC | 2.02e-06 | 2.12e-01 | 0.3055 |
914 | CD2 | C38 | Human | Oral cavity | OSCC | 6.23e-08 | 1.25e+00 | 0.172 |
914 | CD2 | C46 | Human | Oral cavity | OSCC | 5.10e-05 | 2.47e-01 | 0.1673 |
914 | CD2 | C51 | Human | Oral cavity | OSCC | 1.67e-03 | 1.61e-01 | 0.2674 |
914 | CD2 | C57 | Human | Oral cavity | OSCC | 8.29e-04 | 1.33e-01 | 0.1679 |
914 | CD2 | C06 | Human | Oral cavity | OSCC | 2.51e-03 | 9.88e-01 | 0.2699 |
914 | CD2 | C07 | Human | Oral cavity | OSCC | 1.79e-03 | 3.19e-01 | 0.2491 |
914 | CD2 | LN22 | Human | Oral cavity | OSCC | 2.16e-04 | 7.29e-01 | 0.1733 |
914 | CD2 | LN38 | Human | Oral cavity | OSCC | 2.02e-02 | 6.93e-01 | 0.168 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434055 | Esophagus | ESCC | regulation of MAP kinase activity | 102/8552 | 177/18723 | 8.89e-04 | 4.55e-03 | 102 |
GO:00328864 | Esophagus | ESCC | regulation of microtubule-based process | 134/8552 | 240/18723 | 9.44e-04 | 4.80e-03 | 134 |
GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:002240919 | Esophagus | ESCC | positive regulation of cell-cell adhesion | 155/8552 | 284/18723 | 1.50e-03 | 7.06e-03 | 155 |
GO:00508528 | Esophagus | ESCC | T cell receptor signaling pathway | 73/8552 | 123/18723 | 1.54e-03 | 7.24e-03 | 73 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:000223719 | Esophagus | ESCC | response to molecule of bacterial origin | 194/8552 | 363/18723 | 1.64e-03 | 7.61e-03 | 194 |
GO:004825916 | Esophagus | ESCC | regulation of receptor-mediated endocytosis | 66/8552 | 110/18723 | 1.72e-03 | 7.96e-03 | 66 |
GO:190210510 | Esophagus | ESCC | regulation of leukocyte differentiation | 152/8552 | 279/18723 | 1.82e-03 | 8.35e-03 | 152 |
GO:003149811 | Esophagus | ESCC | chromatin disassembly | 16/8552 | 20/18723 | 1.85e-03 | 8.40e-03 | 16 |
GO:003298616 | Esophagus | ESCC | protein-DNA complex disassembly | 16/8552 | 20/18723 | 1.85e-03 | 8.40e-03 | 16 |
GO:00315798 | Esophagus | ESCC | membrane raft organization | 19/8552 | 25/18723 | 2.03e-03 | 9.08e-03 | 19 |
GO:00301481 | Esophagus | ESCC | sphingolipid biosynthetic process | 62/8552 | 103/18723 | 2.10e-03 | 9.38e-03 | 62 |
GO:00507303 | Esophagus | ESCC | regulation of peptidyl-tyrosine phosphorylation | 144/8552 | 264/18723 | 2.22e-03 | 9.78e-03 | 144 |
GO:00610972 | Esophagus | ESCC | regulation of protein tyrosine kinase activity | 55/8552 | 90/18723 | 2.27e-03 | 9.99e-03 | 55 |
GO:000181916 | Esophagus | ESCC | positive regulation of cytokine production | 244/8552 | 467/18723 | 2.29e-03 | 1.01e-02 | 244 |
GO:00512244 | Esophagus | ESCC | negative regulation of protein transport | 74/8552 | 127/18723 | 2.86e-03 | 1.21e-02 | 74 |
GO:00716347 | Esophagus | ESCC | regulation of transforming growth factor beta production | 28/8552 | 41/18723 | 2.88e-03 | 1.21e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
ITGB2 | CD226 | ITGB2_CD226 | ITGB2 | Breast | ADJ |
NECTIN2 | CD226 | NECTIN2_CD226 | NECTIN | Breast | ADJ |
PVR | CD226 | PVR_CD226 | PVR | Breast | ADJ |
CD70 | CD27 | CD70_CD27 | CD70 | Breast | ADJ |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Breast | DCIS |
ITGB2 | CD226 | ITGB2_CD226 | ITGB2 | Breast | DCIS |
NECTIN2 | CD226 | NECTIN2_CD226 | NECTIN | Breast | DCIS |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Breast | IDC |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Cervix | ADJ |
ITGB2 | CD226 | ITGB2_CD226 | ITGB2 | Cervix | ADJ |
NECTIN2 | CD226 | NECTIN2_CD226 | NECTIN | Cervix | ADJ |
CD70 | CD27 | CD70_CD27 | CD70 | Cervix | ADJ |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Cervix | CC |
ITGB2 | CD226 | ITGB2_CD226 | ITGB2 | Cervix | CC |
NECTIN2 | CD226 | NECTIN2_CD226 | NECTIN | Cervix | CC |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Cervix | Healthy |
PTPRC | CD22 | PTPRC_CD22 | CD45 | Cervix | Precancer |
PTPRC | CD22 | PTPRC_CD22 | CD45 | CRC | AD |
CD48 | CD244 | CD48_CD244A | CD48 | CRC | AD |
PTPRC | CD22 | PTPRC_CD22 | CD45 | CRC | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD2 | SNV | Missense_Mutation | c.205N>A | p.Ala69Thr | p.A69T | P06729 | protein_coding | deleterious(0.04) | probably_damaging(0.929) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD2 | SNV | Missense_Mutation | c.150N>C | p.Met50Ile | p.M50I | P06729 | protein_coding | tolerated(0.08) | benign(0.196) | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CD2 | SNV | Missense_Mutation | c.776A>C | p.Glu259Ala | p.E259A | P06729 | protein_coding | tolerated(0.06) | possibly_damaging(0.669) | TCGA-D8-A1XM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CD2 | SNV | Missense_Mutation | novel | c.420C>G | p.Ile140Met | p.I140M | P06729 | protein_coding | tolerated(0.11) | possibly_damaging(0.687) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
CD2 | SNV | Missense_Mutation | c.141T>G | p.Ser47Arg | p.S47R | P06729 | protein_coding | tolerated(0.17) | benign(0.005) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CD2 | SNV | Missense_Mutation | rs769894316 | c.595G>A | p.Glu199Lys | p.E199K | P06729 | protein_coding | tolerated(0.84) | benign(0.001) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CD2 | SNV | Missense_Mutation | c.67N>T | p.Val23Phe | p.V23F | P06729 | protein_coding | tolerated(0.06) | benign(0.086) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CD2 | SNV | Missense_Mutation | c.166N>A | p.Asp56Asn | p.D56N | P06729 | protein_coding | tolerated(0.09) | probably_damaging(0.927) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
CD2 | SNV | Missense_Mutation | c.881N>T | p.Ser294Ile | p.S294I | P06729 | protein_coding | deleterious(0.02) | benign(0.077) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CD2 | SNV | Missense_Mutation | novel | c.320N>C | p.Val107Ala | p.V107A | P06729 | protein_coding | deleterious(0.05) | possibly_damaging(0.811) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | inhibitor | 178103393 | ALEFACEPT | |
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | ALEFACEPT | ALEFACEPT | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | inhibitor | CHEMBL2108742 | SIPLIZUMAB | |
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | ZNCL2 | 8131214 | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | SMS 201-995 | 7628916 | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | inhibitor | CHEMBL1201571 | ALEFACEPT | |
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | Siplizumab | SIPLIZUMAB | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | TUMOR NECROSIS FACTOR | 1359970 | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | COBALT | 8131214 | ||
914 | CD2 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | ALEFACEPT | ALEFACEPT |
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