Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ZFHX3_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ZFHX3_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/ZFHX3_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ZFHX3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ZFHX3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ZFHX3_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ZFHX3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ZFHX3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00715594 | Lung | IAC | response to transforming growth factor beta | 60/2061 | 256/18723 | 9.50e-09 | 1.25e-06 | 60 |
GO:00457858 | Lung | IAC | positive regulation of cell adhesion | 87/2061 | 437/18723 | 2.59e-08 | 3.13e-06 | 87 |
GO:00485116 | Lung | IAC | rhythmic process | 65/2061 | 298/18723 | 4.57e-08 | 5.02e-06 | 65 |
GO:00076237 | Lung | IAC | circadian rhythm | 48/2061 | 210/18723 | 6.13e-07 | 3.67e-05 | 48 |
GO:00329224 | Lung | IAC | circadian regulation of gene expression | 22/2061 | 68/18723 | 1.94e-06 | 8.99e-05 | 22 |
GO:00427526 | Lung | IAC | regulation of circadian rhythm | 27/2061 | 121/18723 | 2.53e-04 | 4.24e-03 | 27 |
GO:004851112 | Lung | AIS | rhythmic process | 61/1849 | 298/18723 | 2.63e-08 | 3.40e-06 | 61 |
GO:000762313 | Lung | AIS | circadian rhythm | 46/1849 | 210/18723 | 1.71e-07 | 1.72e-05 | 46 |
GO:004578513 | Lung | AIS | positive regulation of cell adhesion | 77/1849 | 437/18723 | 3.40e-07 | 2.83e-05 | 77 |
GO:007155912 | Lung | AIS | response to transforming growth factor beta | 51/1849 | 256/18723 | 8.45e-07 | 6.08e-05 | 51 |
GO:003292211 | Lung | AIS | circadian regulation of gene expression | 21/1849 | 68/18723 | 1.33e-06 | 8.53e-05 | 21 |
GO:004275212 | Lung | AIS | regulation of circadian rhythm | 26/1849 | 121/18723 | 1.09e-04 | 2.57e-03 | 26 |
GO:0007626 | Lung | AIS | locomotory behavior | 31/1849 | 179/18723 | 1.39e-03 | 1.70e-02 | 31 |
GO:004578523 | Lung | MIAC | positive regulation of cell adhesion | 47/967 | 437/18723 | 1.62e-06 | 2.10e-04 | 47 |
GO:007155922 | Lung | MIAC | response to transforming growth factor beta | 28/967 | 256/18723 | 1.51e-04 | 5.95e-03 | 28 |
GO:004851110 | Prostate | BPH | rhythmic process | 96/3107 | 298/18723 | 1.88e-11 | 1.31e-09 | 96 |
GO:000762310 | Prostate | BPH | circadian rhythm | 73/3107 | 210/18723 | 1.02e-10 | 6.02e-09 | 73 |
GO:00329228 | Prostate | BPH | circadian regulation of gene expression | 34/3107 | 68/18723 | 2.01e-10 | 1.12e-08 | 34 |
GO:004578518 | Prostate | BPH | positive regulation of cell adhesion | 120/3107 | 437/18723 | 5.22e-09 | 1.90e-07 | 120 |
GO:00715597 | Prostate | BPH | response to transforming growth factor beta | 76/3107 | 256/18723 | 1.14e-07 | 2.73e-06 | 76 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFHX3 | SNV | Missense_Mutation | novel | c.10760N>T | p.Ser3587Leu | p.S3587L | Q15911 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.953) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ZFHX3 | SNV | Missense_Mutation | | c.3239G>C | p.Gly1080Ala | p.G1080A | Q15911 | protein_coding | tolerated(1) | benign(0.056) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZFHX3 | SNV | Missense_Mutation | | c.6956G>A | p.Arg2319Lys | p.R2319K | Q15911 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFHX3 | SNV | Missense_Mutation | | c.4532N>T | p.Gly1511Val | p.G1511V | Q15911 | protein_coding | deleterious(0.05) | possibly_damaging(0.689) | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFHX3 | SNV | Missense_Mutation | rs768186851 | c.3413N>A | p.Ile1138Asn | p.I1138N | Q15911 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BH-A0BQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZFHX3 | SNV | Missense_Mutation | | c.11024N>A | p.Pro3675Gln | p.P3675Q | Q15911 | protein_coding | tolerated_low_confidence(0.09) | benign(0.007) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
ZFHX3 | SNV | Missense_Mutation | | c.4529C>T | p.Ser1510Phe | p.S1510F | Q15911 | protein_coding | deleterious(0) | possibly_damaging(0.495) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFHX3 | SNV | Missense_Mutation | novel | c.4277N>C | p.Arg1426Thr | p.R1426T | Q15911 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
ZFHX3 | SNV | Missense_Mutation | | c.5815N>C | p.Asp1939His | p.D1939H | Q15911 | protein_coding | tolerated(0.05) | probably_damaging(0.956) | TCGA-D8-A1XW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
ZFHX3 | SNV | Missense_Mutation | rs759633185 | c.6395N>G | p.Tyr2132Cys | p.Y2132C | Q15911 | protein_coding | tolerated(0.33) | probably_damaging(0.995) | TCGA-E2-A15G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |