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Gene: ZFAND6 |
Gene summary for ZFAND6 |
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Gene information | Species | Human | Gene symbol | ZFAND6 | Gene ID | 54469 |
Gene name | zinc finger AN1-type containing 6 | |
Gene Alias | AWP1 | |
Cytomap | 15q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | Q6FIF0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54469 | ZFAND6 | CCI_2 | Human | Cervix | CC | 1.87e-04 | 7.26e-01 | 0.5249 |
54469 | ZFAND6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.25e-18 | -6.52e-01 | 0.0155 |
54469 | ZFAND6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.45e-04 | -4.92e-01 | -0.1808 |
54469 | ZFAND6 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.90e-02 | -7.48e-01 | 0.0216 |
54469 | ZFAND6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.33e-05 | -5.91e-01 | -0.1207 |
54469 | ZFAND6 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.14e-10 | -4.22e-01 | -0.1464 |
54469 | ZFAND6 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.18e-16 | -4.67e-01 | -0.1001 |
54469 | ZFAND6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.52e-02 | -4.43e-01 | -0.059 |
54469 | ZFAND6 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.98e-07 | -5.39e-01 | 0.096 |
54469 | ZFAND6 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.53e-02 | -8.37e-01 | 0.0451 |
54469 | ZFAND6 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.26e-07 | -5.77e-01 | 0.0338 |
54469 | ZFAND6 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.07e-16 | -5.12e-01 | 0.0674 |
54469 | ZFAND6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.41e-03 | -3.25e-01 | 0.294 |
54469 | ZFAND6 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.26e-25 | -6.01e-01 | 0.3859 |
54469 | ZFAND6 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.44e-02 | -5.70e-01 | 0.2585 |
54469 | ZFAND6 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.00e-13 | -4.56e-01 | 0.3005 |
54469 | ZFAND6 | A001-C-207 | Human | Colorectum | FAP | 5.62e-07 | -4.28e-01 | 0.1278 |
54469 | ZFAND6 | A015-C-203 | Human | Colorectum | FAP | 1.82e-34 | -5.57e-01 | -0.1294 |
54469 | ZFAND6 | A015-C-204 | Human | Colorectum | FAP | 2.93e-07 | -3.89e-01 | -0.0228 |
54469 | ZFAND6 | A014-C-040 | Human | Colorectum | FAP | 2.03e-04 | -3.56e-01 | -0.1184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000660520 | Oral cavity | OSCC | protein targeting | 204/7305 | 314/18723 | 6.78e-21 | 1.13e-18 | 204 |
GO:004312218 | Oral cavity | OSCC | regulation of I-kappaB kinase/NF-kappaB signaling | 155/7305 | 249/18723 | 7.79e-14 | 4.14e-12 | 155 |
GO:000724910 | Oral cavity | OSCC | I-kappaB kinase/NF-kappaB signaling | 169/7305 | 281/18723 | 4.69e-13 | 2.25e-11 | 169 |
GO:003461218 | Oral cavity | OSCC | response to tumor necrosis factor | 143/7305 | 253/18723 | 1.09e-08 | 2.23e-07 | 143 |
GO:007135618 | Oral cavity | OSCC | cellular response to tumor necrosis factor | 128/7305 | 229/18723 | 1.49e-07 | 2.49e-06 | 128 |
GO:0006625 | Oral cavity | OSCC | protein targeting to peroxisome | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
GO:0072662 | Oral cavity | OSCC | protein localization to peroxisome | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
GO:0072663 | Oral cavity | OSCC | establishment of protein localization to peroxisome | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
GO:0043574 | Oral cavity | OSCC | peroxisomal transport | 16/7305 | 22/18723 | 1.40e-03 | 6.79e-03 | 16 |
GO:00070312 | Oral cavity | OSCC | peroxisome organization | 23/7305 | 36/18723 | 2.19e-03 | 9.95e-03 | 23 |
GO:007259419 | Oral cavity | LP | establishment of protein localization to organelle | 205/4623 | 422/18723 | 6.76e-27 | 3.85e-24 | 205 |
GO:0006605110 | Oral cavity | LP | protein targeting | 156/4623 | 314/18723 | 5.43e-22 | 1.62e-19 | 156 |
GO:004312219 | Oral cavity | LP | regulation of I-kappaB kinase/NF-kappaB signaling | 103/4623 | 249/18723 | 4.48e-09 | 1.90e-07 | 103 |
GO:000724917 | Oral cavity | LP | I-kappaB kinase/NF-kappaB signaling | 110/4623 | 281/18723 | 4.94e-08 | 1.70e-06 | 110 |
GO:003461219 | Oral cavity | LP | response to tumor necrosis factor | 83/4623 | 253/18723 | 2.10e-03 | 1.54e-02 | 83 |
GO:007135619 | Oral cavity | LP | cellular response to tumor necrosis factor | 76/4623 | 229/18723 | 2.24e-03 | 1.62e-02 | 76 |
GO:00070311 | Oral cavity | LP | peroxisome organization | 17/4623 | 36/18723 | 2.74e-03 | 1.92e-02 | 17 |
GO:00066251 | Oral cavity | LP | protein targeting to peroxisome | 10/4623 | 18/18723 | 4.91e-03 | 3.06e-02 | 10 |
GO:00726621 | Oral cavity | LP | protein localization to peroxisome | 10/4623 | 18/18723 | 4.91e-03 | 3.06e-02 | 10 |
GO:00726631 | Oral cavity | LP | establishment of protein localization to peroxisome | 10/4623 | 18/18723 | 4.91e-03 | 3.06e-02 | 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFAND6 | SNV | Missense_Mutation | rs12890 | c.607N>A | p.Glu203Lys | p.E203K | Q6FIF0 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
ZFAND6 | SNV | Missense_Mutation | novel | c.71C>T | p.Pro24Leu | p.P24L | Q6FIF0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A2IN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZFAND6 | SNV | Missense_Mutation | novel | c.557N>C | p.Lys186Thr | p.K186T | Q6FIF0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFAND6 | SNV | Missense_Mutation | c.569C>T | p.Ala190Val | p.A190V | Q6FIF0 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZFAND6 | SNV | Missense_Mutation | rs773057418 | c.442N>T | p.Arg148Cys | p.R148C | Q6FIF0 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFAND6 | SNV | Missense_Mutation | novel | c.149C>A | p.Pro50Gln | p.P50Q | Q6FIF0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZFAND6 | SNV | Missense_Mutation | c.379N>G | p.Thr127Ala | p.T127A | Q6FIF0 | protein_coding | tolerated(0.39) | benign(0.01) | TCGA-78-7220-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ZFAND6 | SNV | Missense_Mutation | c.283C>T | p.Leu95Phe | p.L95F | Q6FIF0 | protein_coding | tolerated(0.27) | probably_damaging(0.991) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZFAND6 | SNV | Missense_Mutation | novel | c.271N>C | p.Ser91Pro | p.S91P | Q6FIF0 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFAND6 | SNV | Missense_Mutation | c.379A>G | p.Thr127Ala | p.T127A | Q6FIF0 | protein_coding | tolerated(0.39) | benign(0.01) | TCGA-56-6545-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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