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Gene: YEATS2 |
Gene summary for YEATS2 |
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Gene information | Species | Human | Gene symbol | YEATS2 | Gene ID | 55689 |
Gene name | YEATS domain containing 2 | |
Gene Alias | FAME4 | |
Cytomap | 3q27.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9ULM3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55689 | YEATS2 | CCI_1 | Human | Cervix | CC | 3.77e-19 | 1.22e+00 | 0.528 |
55689 | YEATS2 | CCI_2 | Human | Cervix | CC | 1.79e-11 | 1.15e+00 | 0.5249 |
55689 | YEATS2 | CCI_3 | Human | Cervix | CC | 3.34e-30 | 1.31e+00 | 0.516 |
55689 | YEATS2 | LZE2T | Human | Esophagus | ESCC | 2.82e-08 | 7.10e-01 | 0.082 |
55689 | YEATS2 | LZE4T | Human | Esophagus | ESCC | 2.23e-27 | 7.10e-01 | 0.0811 |
55689 | YEATS2 | LZE5T | Human | Esophagus | ESCC | 1.14e-02 | 3.88e-01 | 0.0514 |
55689 | YEATS2 | LZE7T | Human | Esophagus | ESCC | 1.32e-09 | 3.24e-01 | 0.0667 |
55689 | YEATS2 | LZE20T | Human | Esophagus | ESCC | 1.33e-05 | 1.37e-01 | 0.0662 |
55689 | YEATS2 | LZE22T | Human | Esophagus | ESCC | 3.72e-02 | 2.81e-01 | 0.068 |
55689 | YEATS2 | LZE24T | Human | Esophagus | ESCC | 4.85e-19 | 4.80e-01 | 0.0596 |
55689 | YEATS2 | LZE21T | Human | Esophagus | ESCC | 3.38e-08 | 5.76e-01 | 0.0655 |
55689 | YEATS2 | P1T-E | Human | Esophagus | ESCC | 9.50e-09 | 3.38e-01 | 0.0875 |
55689 | YEATS2 | P2T-E | Human | Esophagus | ESCC | 3.60e-46 | 8.49e-01 | 0.1177 |
55689 | YEATS2 | P4T-E | Human | Esophagus | ESCC | 4.58e-31 | 6.26e-01 | 0.1323 |
55689 | YEATS2 | P5T-E | Human | Esophagus | ESCC | 3.45e-24 | 4.45e-01 | 0.1327 |
55689 | YEATS2 | P8T-E | Human | Esophagus | ESCC | 1.02e-21 | 3.48e-01 | 0.0889 |
55689 | YEATS2 | P9T-E | Human | Esophagus | ESCC | 4.78e-15 | 3.52e-01 | 0.1131 |
55689 | YEATS2 | P10T-E | Human | Esophagus | ESCC | 3.87e-37 | 6.52e-01 | 0.116 |
55689 | YEATS2 | P11T-E | Human | Esophagus | ESCC | 1.32e-18 | 5.23e-01 | 0.1426 |
55689 | YEATS2 | P12T-E | Human | Esophagus | ESCC | 3.67e-18 | 3.77e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657314 | Thyroid | ATC | histone acetylation | 89/6293 | 152/18723 | 2.31e-10 | 6.72e-09 | 89 |
GO:004396611 | Thyroid | ATC | histone H3 acetylation | 34/6293 | 61/18723 | 3.10e-04 | 1.94e-03 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YEATS2 | SNV | Missense_Mutation | c.557G>C | p.Gly186Ala | p.G186A | Q9ULM3 | protein_coding | tolerated(0.35) | benign(0.021) | TCGA-A2-A0T3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
YEATS2 | SNV | Missense_Mutation | novel | c.712N>A | p.Val238Ile | p.V238I | Q9ULM3 | protein_coding | deleterious(0.03) | probably_damaging(0.979) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
YEATS2 | SNV | Missense_Mutation | c.1667N>G | p.Ser556Cys | p.S556C | Q9ULM3 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.781) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
YEATS2 | SNV | Missense_Mutation | rs750911091 | c.851N>G | p.Glu284Gly | p.E284G | Q9ULM3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AQ-A04H-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
YEATS2 | SNV | Missense_Mutation | novel | c.536N>T | p.Arg179Met | p.R179M | Q9ULM3 | protein_coding | deleterious(0) | possibly_damaging(0.641) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
YEATS2 | SNV | Missense_Mutation | novel | c.3841N>A | p.Gln1281Lys | p.Q1281K | Q9ULM3 | protein_coding | deleterious(0.03) | benign(0.112) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
YEATS2 | SNV | Missense_Mutation | c.46N>A | p.Glu16Lys | p.E16K | Q9ULM3 | protein_coding | deleterious(0.01) | possibly_damaging(0.651) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
YEATS2 | SNV | Missense_Mutation | novel | c.123G>C | p.Lys41Asn | p.K41N | Q9ULM3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
YEATS2 | SNV | Missense_Mutation | c.2932G>T | p.Val978Leu | p.V978L | Q9ULM3 | protein_coding | tolerated_low_confidence(0.74) | benign(0.005) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
YEATS2 | SNV | Missense_Mutation | c.251C>G | p.Ala84Gly | p.A84G | Q9ULM3 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-E9-A22G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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