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Gene: WDR1 |
Gene summary for WDR1 |
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Gene information | Species | Human | Gene symbol | WDR1 | Gene ID | 9948 |
Gene name | WD repeat domain 1 | |
Gene Alias | AIP1 | |
Cytomap | 4p16.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O75083 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9948 | WDR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.50e-12 | 7.03e-01 | -0.1808 |
9948 | WDR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.16e-12 | 7.43e-01 | -0.0811 |
9948 | WDR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.16e-09 | 5.47e-01 | -0.1088 |
9948 | WDR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.84e-26 | 7.52e-01 | -0.1954 |
9948 | WDR1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.94e-10 | 1.37e+00 | -0.2602 |
9948 | WDR1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.18e-05 | 8.15e-01 | -0.2196 |
9948 | WDR1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.25e-02 | 4.03e-01 | -0.1207 |
9948 | WDR1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.23e-05 | 6.57e-01 | -0.1526 |
9948 | WDR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.50e-17 | 6.21e-01 | -0.1464 |
9948 | WDR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.94e-05 | 2.52e-01 | -0.1001 |
9948 | WDR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.98e-15 | 8.14e-01 | -0.059 |
9948 | WDR1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.65e-09 | 1.11e+00 | -0.1706 |
9948 | WDR1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.39e-06 | 7.70e-01 | -0.2061 |
9948 | WDR1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.04e-02 | 3.81e-01 | -0.0179 |
9948 | WDR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.23e-09 | 4.61e-01 | 0.096 |
9948 | WDR1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.16e-02 | 4.75e-01 | -0.0177 |
9948 | WDR1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.82e-05 | 8.33e-01 | 0.0171 |
9948 | WDR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.66e-10 | 4.19e-01 | 0.0674 |
9948 | WDR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.51e-15 | 4.73e-01 | 0.294 |
9948 | WDR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.57e-10 | 5.91e-01 | 0.281 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510521 | Colorectum | SER | regulation of DNA metabolic process | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
GO:00436241 | Colorectum | SER | cellular protein complex disassembly | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
GO:00451971 | Colorectum | SER | establishment or maintenance of epithelial cell apical/basal polarity | 16/2897 | 44/18723 | 5.64e-04 | 7.83e-03 | 16 |
GO:00350881 | Colorectum | SER | establishment or maintenance of apical/basal cell polarity | 17/2897 | 49/18723 | 7.17e-04 | 9.44e-03 | 17 |
GO:00612451 | Colorectum | SER | establishment or maintenance of bipolar cell polarity | 17/2897 | 49/18723 | 7.17e-04 | 9.44e-03 | 17 |
GO:00512611 | Colorectum | SER | protein depolymerization | 31/2897 | 114/18723 | 9.18e-04 | 1.11e-02 | 31 |
GO:00422541 | Colorectum | SER | ribosome biogenesis | 66/2897 | 299/18723 | 1.48e-03 | 1.60e-02 | 66 |
GO:00308651 | Colorectum | SER | cortical cytoskeleton organization | 19/2897 | 61/18723 | 1.59e-03 | 1.69e-02 | 19 |
GO:00300991 | Colorectum | SER | myeloid cell differentiation | 80/2897 | 381/18723 | 2.28e-03 | 2.18e-02 | 80 |
GO:19018791 | Colorectum | SER | regulation of protein depolymerization | 24/2897 | 87/18723 | 2.69e-03 | 2.44e-02 | 24 |
GO:00310321 | Colorectum | SER | actomyosin structure organization | 45/2897 | 196/18723 | 3.60e-03 | 3.03e-02 | 45 |
GO:0030011 | Colorectum | SER | maintenance of cell polarity | 8/2897 | 19/18723 | 4.95e-03 | 3.84e-02 | 8 |
GO:00432441 | Colorectum | SER | regulation of protein-containing complex disassembly | 30/2897 | 121/18723 | 5.03e-03 | 3.88e-02 | 30 |
GO:00070152 | Colorectum | MSS | actin filament organization | 146/3467 | 442/18723 | 1.16e-13 | 2.67e-11 | 146 |
GO:00325352 | Colorectum | MSS | regulation of cellular component size | 127/3467 | 383/18723 | 3.44e-12 | 5.79e-10 | 127 |
GO:00329702 | Colorectum | MSS | regulation of actin filament-based process | 128/3467 | 397/18723 | 2.47e-11 | 3.49e-09 | 128 |
GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
GO:00226042 | Colorectum | MSS | regulation of cell morphogenesis | 103/3467 | 309/18723 | 2.70e-10 | 2.56e-08 | 103 |
GO:19029032 | Colorectum | MSS | regulation of supramolecular fiber organization | 121/3467 | 383/18723 | 3.63e-10 | 3.28e-08 | 121 |
GO:00081542 | Colorectum | MSS | actin polymerization or depolymerization | 79/3467 | 218/18723 | 4.14e-10 | 3.49e-08 | 79 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR1 | SNV | Missense_Mutation | novel | c.1043N>G | p.Tyr348Cys | p.Y348C | O75083 | protein_coding | tolerated(0.14) | possibly_damaging(0.807) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
WDR1 | SNV | Missense_Mutation | novel | c.1041N>G | p.Asn347Lys | p.N347K | O75083 | protein_coding | tolerated(0.3) | possibly_damaging(0.739) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
WDR1 | SNV | Missense_Mutation | c.1606N>C | p.Val536Leu | p.V536L | O75083 | protein_coding | tolerated(0.11) | benign(0.02) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
WDR1 | deletion | Frame_Shift_Del | novel | c.748delN | p.Leu250PhefsTer16 | p.L250Ffs*16 | O75083 | protein_coding | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | SD | |||
WDR1 | SNV | Missense_Mutation | novel | c.532C>T | p.Pro178Ser | p.P178S | O75083 | protein_coding | deleterious(0) | benign(0.03) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR1 | SNV | Missense_Mutation | rs545497657 | c.700G>A | p.Asp234Asn | p.D234N | O75083 | protein_coding | tolerated(0.49) | benign(0.011) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
WDR1 | SNV | Missense_Mutation | rs868174972 | c.200N>T | p.Ala67Val | p.A67V | O75083 | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDR1 | SNV | Missense_Mutation | novel | c.638N>C | p.Ile213Thr | p.I213T | O75083 | protein_coding | deleterious(0.01) | possibly_damaging(0.493) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
WDR1 | SNV | Missense_Mutation | c.1319N>A | p.Ser440Asn | p.S440N | O75083 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
WDR1 | SNV | Missense_Mutation | rs370326840 | c.1222G>A | p.Val408Ile | p.V408I | O75083 | protein_coding | tolerated(0.4) | benign(0) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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