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Gene: UTP20 |
Gene summary for UTP20 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | UTP20 | Gene ID | 27340 |
| Gene name | UTP20 small subunit processome component | |
| Gene Alias | 1A6/DRIM | |
| Cytomap | 12q23.2 | |
| Gene Type | protein-coding | GO ID | GO:0000447 | UniProtAcc | O75691 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 27340 | UTP20 | LZE4T | Human | Esophagus | ESCC | 2.75e-05 | 1.37e-01 | 0.0811 |
| 27340 | UTP20 | LZE8T | Human | Esophagus | ESCC | 6.68e-07 | 2.61e-01 | 0.067 |
| 27340 | UTP20 | LZE24T | Human | Esophagus | ESCC | 8.95e-05 | 8.98e-02 | 0.0596 |
| 27340 | UTP20 | P1T-E | Human | Esophagus | ESCC | 2.28e-02 | 1.95e-01 | 0.0875 |
| 27340 | UTP20 | P2T-E | Human | Esophagus | ESCC | 1.10e-28 | 5.20e-01 | 0.1177 |
| 27340 | UTP20 | P4T-E | Human | Esophagus | ESCC | 1.61e-05 | 2.21e-01 | 0.1323 |
| 27340 | UTP20 | P5T-E | Human | Esophagus | ESCC | 8.67e-10 | 1.55e-01 | 0.1327 |
| 27340 | UTP20 | P8T-E | Human | Esophagus | ESCC | 1.63e-13 | 2.73e-01 | 0.0889 |
| 27340 | UTP20 | P10T-E | Human | Esophagus | ESCC | 8.36e-10 | 1.85e-01 | 0.116 |
| 27340 | UTP20 | P11T-E | Human | Esophagus | ESCC | 1.47e-05 | 3.04e-01 | 0.1426 |
| 27340 | UTP20 | P12T-E | Human | Esophagus | ESCC | 8.89e-07 | 1.38e-01 | 0.1122 |
| 27340 | UTP20 | P15T-E | Human | Esophagus | ESCC | 1.62e-14 | 3.55e-01 | 0.1149 |
| 27340 | UTP20 | P16T-E | Human | Esophagus | ESCC | 7.12e-21 | 2.93e-01 | 0.1153 |
| 27340 | UTP20 | P20T-E | Human | Esophagus | ESCC | 5.15e-06 | 2.05e-01 | 0.1124 |
| 27340 | UTP20 | P21T-E | Human | Esophagus | ESCC | 1.87e-32 | 5.75e-01 | 0.1617 |
| 27340 | UTP20 | P22T-E | Human | Esophagus | ESCC | 3.89e-13 | 1.76e-01 | 0.1236 |
| 27340 | UTP20 | P23T-E | Human | Esophagus | ESCC | 2.26e-21 | 2.91e-01 | 0.108 |
| 27340 | UTP20 | P24T-E | Human | Esophagus | ESCC | 3.18e-08 | 1.20e-01 | 0.1287 |
| 27340 | UTP20 | P26T-E | Human | Esophagus | ESCC | 2.59e-13 | 2.50e-01 | 0.1276 |
| 27340 | UTP20 | P27T-E | Human | Esophagus | ESCC | 7.70e-18 | 2.62e-01 | 0.1055 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:004227435 | Thyroid | ATC | ribosomal small subunit biogenesis | 55/6293 | 73/18723 | 3.33e-13 | 1.55e-11 | 55 |
| GO:003049013 | Thyroid | ATC | maturation of SSU-rRNA | 35/6293 | 50/18723 | 1.56e-07 | 2.52e-06 | 35 |
| GO:000046911 | Thyroid | ATC | cleavage involved in rRNA processing | 21/6293 | 27/18723 | 3.28e-06 | 3.69e-05 | 21 |
| GO:009050112 | Thyroid | ATC | RNA phosphodiester bond hydrolysis | 76/6293 | 152/18723 | 2.07e-05 | 1.86e-04 | 76 |
| GO:000046012 | Thyroid | ATC | maturation of 5.8S rRNA | 24/6293 | 35/18723 | 2.49e-05 | 2.16e-04 | 24 |
| GO:000046213 | Thyroid | ATC | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 25/6293 | 37/18723 | 2.50e-05 | 2.16e-04 | 25 |
| GO:000047811 | Thyroid | ATC | endonucleolytic cleavage involved in rRNA processing | 11/6293 | 15/18723 | 1.94e-03 | 9.41e-03 | 11 |
| GO:000047911 | Thyroid | ATC | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 11/6293 | 15/18723 | 1.94e-03 | 9.41e-03 | 11 |
| GO:000046611 | Thyroid | ATC | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 15/6293 | 24/18723 | 3.52e-03 | 1.56e-02 | 15 |
| GO:009030511 | Thyroid | ATC | nucleic acid phosphodiester bond hydrolysis | 107/6293 | 261/18723 | 7.21e-03 | 2.84e-02 | 107 |
| Page: 1 2 3 4 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| UTP20 | SNV | Missense_Mutation | novel | c.5159N>C | p.Arg1720Pro | p.R1720P | O75691 | protein_coding | tolerated(0.33) | benign(0) | TCGA-A2-A3XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PR |
| UTP20 | SNV | Missense_Mutation | rs778767258 | c.5596C>T | p.Arg1866Cys | p.R1866C | O75691 | protein_coding | deleterious(0) | possibly_damaging(0.793) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| UTP20 | SNV | Missense_Mutation | c.3095N>G | p.Ser1032Cys | p.S1032C | O75691 | protein_coding | deleterious(0.03) | probably_damaging(0.99) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| UTP20 | SNV | Missense_Mutation | novel | c.6103N>A | p.Pro2035Thr | p.P2035T | O75691 | protein_coding | tolerated(0.06) | possibly_damaging(0.786) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| UTP20 | SNV | Missense_Mutation | novel | c.3103G>T | p.Gly1035Cys | p.G1035C | O75691 | protein_coding | deleterious(0.02) | probably_damaging(0.968) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| UTP20 | SNV | Missense_Mutation | c.29N>A | p.Thr10Asn | p.T10N | O75691 | protein_coding | deleterious(0.03) | benign(0.084) | TCGA-AO-A03T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| UTP20 | SNV | Missense_Mutation | c.5194N>G | p.Ser1732Gly | p.S1732G | O75691 | protein_coding | tolerated(0.33) | benign(0.009) | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| UTP20 | SNV | Missense_Mutation | c.3392N>T | p.Ser1131Leu | p.S1131L | O75691 | protein_coding | deleterious(0) | benign(0.282) | TCGA-B6-A0RI-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
| UTP20 | SNV | Missense_Mutation | rs200357157 | c.7756N>A | p.Glu2586Lys | p.E2586K | O75691 | protein_coding | tolerated(0.33) | benign(0.014) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
| UTP20 | SNV | Missense_Mutation | c.5905G>C | p.Gly1969Arg | p.G1969R | O75691 | protein_coding | deleterious(0) | possibly_damaging(0.838) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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