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Gene: UBXN2B |
Gene summary for UBXN2B |
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Gene information | Species | Human | Gene symbol | UBXN2B | Gene ID | 137886 |
Gene name | UBX domain protein 2B | |
Gene Alias | p37 | |
Cytomap | 8q12.1 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q14CS0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
137886 | UBXN2B | LZE4T | Human | Esophagus | ESCC | 3.23e-04 | 1.57e-01 | 0.0811 |
137886 | UBXN2B | LZE20T | Human | Esophagus | ESCC | 1.73e-06 | 1.30e-01 | 0.0662 |
137886 | UBXN2B | LZE24T | Human | Esophagus | ESCC | 3.92e-05 | 1.73e-01 | 0.0596 |
137886 | UBXN2B | P1T-E | Human | Esophagus | ESCC | 1.26e-02 | 1.19e-01 | 0.0875 |
137886 | UBXN2B | P2T-E | Human | Esophagus | ESCC | 7.97e-15 | 2.33e-01 | 0.1177 |
137886 | UBXN2B | P4T-E | Human | Esophagus | ESCC | 1.18e-14 | 2.88e-01 | 0.1323 |
137886 | UBXN2B | P5T-E | Human | Esophagus | ESCC | 7.89e-06 | 1.52e-01 | 0.1327 |
137886 | UBXN2B | P8T-E | Human | Esophagus | ESCC | 4.58e-04 | 1.38e-01 | 0.0889 |
137886 | UBXN2B | P9T-E | Human | Esophagus | ESCC | 5.37e-06 | 8.99e-02 | 0.1131 |
137886 | UBXN2B | P10T-E | Human | Esophagus | ESCC | 1.18e-09 | 1.71e-01 | 0.116 |
137886 | UBXN2B | P11T-E | Human | Esophagus | ESCC | 1.51e-02 | 1.91e-01 | 0.1426 |
137886 | UBXN2B | P12T-E | Human | Esophagus | ESCC | 5.11e-11 | 2.14e-01 | 0.1122 |
137886 | UBXN2B | P15T-E | Human | Esophagus | ESCC | 2.94e-07 | 1.52e-01 | 0.1149 |
137886 | UBXN2B | P16T-E | Human | Esophagus | ESCC | 2.94e-25 | 4.42e-01 | 0.1153 |
137886 | UBXN2B | P17T-E | Human | Esophagus | ESCC | 5.29e-06 | 2.69e-01 | 0.1278 |
137886 | UBXN2B | P20T-E | Human | Esophagus | ESCC | 1.10e-12 | 2.45e-01 | 0.1124 |
137886 | UBXN2B | P21T-E | Human | Esophagus | ESCC | 5.24e-14 | 2.17e-01 | 0.1617 |
137886 | UBXN2B | P22T-E | Human | Esophagus | ESCC | 5.88e-08 | 3.94e-02 | 0.1236 |
137886 | UBXN2B | P23T-E | Human | Esophagus | ESCC | 3.28e-09 | 1.54e-01 | 0.108 |
137886 | UBXN2B | P24T-E | Human | Esophagus | ESCC | 1.03e-09 | 1.75e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0000280 | Liver | HCC | nuclear division | 220/7958 | 439/18723 | 6.90e-04 | 4.25e-03 | 220 |
GO:00900683 | Liver | HCC | positive regulation of cell cycle process | 125/7958 | 236/18723 | 7.21e-04 | 4.40e-03 | 125 |
GO:007269811 | Liver | HCC | protein localization to microtubule cytoskeleton | 35/7958 | 54/18723 | 7.73e-04 | 4.65e-03 | 35 |
GO:0031468 | Liver | HCC | nuclear envelope reassembly | 12/7958 | 14/18723 | 1.17e-03 | 6.54e-03 | 12 |
GO:0061025 | Liver | HCC | membrane fusion | 88/7958 | 163/18723 | 1.98e-03 | 1.00e-02 | 88 |
GO:190550811 | Liver | HCC | protein localization to microtubule organizing center | 23/7958 | 35/18723 | 4.72e-03 | 2.02e-02 | 23 |
GO:007153911 | Liver | HCC | protein localization to centrosome | 21/7958 | 33/18723 | 1.16e-02 | 4.28e-02 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBXN2B | SNV | Missense_Mutation | c.754N>A | p.Asp252Asn | p.D252N | Q14CS0 | protein_coding | deleterious(0.02) | possibly_damaging(0.657) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UBXN2B | SNV | Missense_Mutation | rs747002448 | c.626N>C | p.Arg209Thr | p.R209T | Q14CS0 | protein_coding | deleterious(0) | possibly_damaging(0.721) | TCGA-D8-A27F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
UBXN2B | SNV | Missense_Mutation | c.356N>A | p.Gly119Glu | p.G119E | Q14CS0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EA-A3QE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
UBXN2B | SNV | Missense_Mutation | c.847C>T | p.Arg283Trp | p.R283W | Q14CS0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBXN2B | SNV | Missense_Mutation | novel | c.560N>G | p.Leu187Arg | p.L187R | Q14CS0 | protein_coding | tolerated(0.82) | benign(0.223) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
UBXN2B | SNV | Missense_Mutation | c.776N>A | p.Ile259Asn | p.I259N | Q14CS0 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
UBXN2B | SNV | Missense_Mutation | novel | c.497C>T | p.Pro166Leu | p.P166L | Q14CS0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
UBXN2B | SNV | Missense_Mutation | c.731N>G | p.Leu244Arg | p.L244R | Q14CS0 | protein_coding | tolerated(0.39) | possibly_damaging(0.467) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UBXN2B | SNV | Missense_Mutation | rs765005760 | c.385N>T | p.Arg129Trp | p.R129W | Q14CS0 | protein_coding | deleterious(0.01) | benign(0.425) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBXN2B | SNV | Missense_Mutation | c.242N>T | p.Thr81Ile | p.T81I | Q14CS0 | protein_coding | tolerated(0.09) | benign(0.143) | TCGA-AP-A0LE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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