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Gene: UBE2L3 |
Gene summary for UBE2L3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | UBE2L3 | Gene ID | 7332 |
Gene name | ubiquitin conjugating enzyme E2 L3 | |
Gene Alias | E2-F1 | |
Cytomap | 22q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | P68036 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7332 | UBE2L3 | GSM4909281 | Human | Breast | IDC | 1.72e-22 | 6.11e-01 | 0.21 |
7332 | UBE2L3 | GSM4909282 | Human | Breast | IDC | 3.19e-02 | 3.27e-01 | -0.0288 |
7332 | UBE2L3 | GSM4909285 | Human | Breast | IDC | 2.67e-10 | 4.19e-01 | 0.21 |
7332 | UBE2L3 | GSM4909288 | Human | Breast | IDC | 8.16e-05 | 4.25e-02 | 0.0988 |
7332 | UBE2L3 | GSM4909291 | Human | Breast | IDC | 1.88e-09 | 5.00e-01 | 0.1753 |
7332 | UBE2L3 | GSM4909294 | Human | Breast | IDC | 5.06e-04 | 1.51e-02 | 0.2022 |
7332 | UBE2L3 | GSM4909296 | Human | Breast | IDC | 7.18e-11 | 2.32e-02 | 0.1524 |
7332 | UBE2L3 | GSM4909297 | Human | Breast | IDC | 4.52e-18 | -1.36e-01 | 0.1517 |
7332 | UBE2L3 | GSM4909311 | Human | Breast | IDC | 5.23e-33 | -2.72e-01 | 0.1534 |
7332 | UBE2L3 | GSM4909312 | Human | Breast | IDC | 1.39e-12 | -9.81e-02 | 0.1552 |
7332 | UBE2L3 | GSM4909319 | Human | Breast | IDC | 7.93e-41 | -2.27e-01 | 0.1563 |
7332 | UBE2L3 | GSM4909320 | Human | Breast | IDC | 3.68e-04 | -1.79e-01 | 0.1575 |
7332 | UBE2L3 | GSM4909321 | Human | Breast | IDC | 2.52e-15 | 9.12e-03 | 0.1559 |
7332 | UBE2L3 | brca1 | Human | Breast | Precancer | 5.08e-24 | 6.84e-01 | -0.0338 |
7332 | UBE2L3 | brca2 | Human | Breast | Precancer | 6.84e-14 | 4.54e-01 | -0.024 |
7332 | UBE2L3 | brca3 | Human | Breast | Precancer | 2.99e-06 | 3.30e-01 | -0.0263 |
7332 | UBE2L3 | NCCBC14 | Human | Breast | DCIS | 2.87e-16 | 2.53e-01 | 0.2021 |
7332 | UBE2L3 | NCCBC2 | Human | Breast | DCIS | 4.22e-05 | 5.50e-02 | 0.1554 |
7332 | UBE2L3 | NCCBC5 | Human | Breast | DCIS | 7.48e-16 | 1.82e-01 | 0.2046 |
7332 | UBE2L3 | P1 | Human | Breast | IDC | 3.67e-17 | -2.21e-01 | 0.1527 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:1903320 | Colorectum | AD | regulation of protein modification by small protein conjugation or removal | 86/3918 | 242/18723 | 9.43e-08 | 4.65e-06 | 86 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0090316 | Colorectum | AD | positive regulation of intracellular protein transport | 62/3918 | 160/18723 | 1.82e-07 | 7.79e-06 | 62 |
GO:0032388 | Colorectum | AD | positive regulation of intracellular transport | 74/3918 | 202/18723 | 1.83e-07 | 7.80e-06 | 74 |
GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0033157 | Colorectum | AD | regulation of intracellular protein transport | 80/3918 | 229/18723 | 5.81e-07 | 2.09e-05 | 80 |
GO:0071383 | Colorectum | AD | cellular response to steroid hormone stimulus | 73/3918 | 204/18723 | 6.31e-07 | 2.24e-05 | 73 |
GO:0072655 | Colorectum | AD | establishment of protein localization to mitochondrion | 47/3918 | 120/18723 | 3.76e-06 | 1.04e-04 | 47 |
GO:0031396 | Colorectum | AD | regulation of protein ubiquitination | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:0048545 | Colorectum | AD | response to steroid hormone | 104/3918 | 339/18723 | 1.33e-05 | 2.90e-04 | 104 |
GO:0006626 | Colorectum | AD | protein targeting to mitochondrion | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:1903533 | Colorectum | AD | regulation of protein targeting | 31/3918 | 81/18723 | 2.61e-04 | 3.25e-03 | 31 |
GO:1903747 | Colorectum | AD | regulation of establishment of protein localization to mitochondrion | 21/3918 | 50/18723 | 5.97e-04 | 6.31e-03 | 21 |
GO:1903214 | Colorectum | AD | regulation of protein targeting to mitochondrion | 18/3918 | 44/18723 | 2.06e-03 | 1.64e-02 | 18 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502223 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0501234 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502233 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0501243 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0502243 | Breast | DCIS | Pathways of neurodegeneration - multiple diseases | 114/846 | 476/8465 | 4.74e-20 | 1.53e-18 | 1.13e-18 | 114 |
hsa0501253 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0502253 | Breast | DCIS | Pathways of neurodegeneration - multiple diseases | 114/846 | 476/8465 | 4.74e-20 | 1.53e-18 | 1.13e-18 | 114 |
hsa05012 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa050121 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa050122 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBE2L3 | SNV | Missense_Mutation | novel | c.240C>A | p.Phe80Leu | p.F80L | P68036 | protein_coding | tolerated(0.37) | benign(0.212) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBE2L3 | SNV | Missense_Mutation | c.317A>C | p.Lys106Thr | p.K106T | P68036 | protein_coding | tolerated(0.13) | probably_damaging(0.975) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UBE2L3 | SNV | Missense_Mutation | novel | c.374A>C | p.Lys125Thr | p.K125T | P68036 | protein_coding | tolerated(0.19) | possibly_damaging(0.823) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBE2L3 | SNV | Missense_Mutation | c.271N>A | p.Leu91Met | p.L91M | P68036 | protein_coding | deleterious(0.04) | possibly_damaging(0.654) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
UBE2L3 | SNV | Missense_Mutation | novel | c.451N>A | p.Glu151Lys | p.E151K | P68036 | protein_coding | deleterious(0.04) | benign(0.193) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBE2L3 | deletion | In_Frame_Del | c.326_331delNNNNNN | p.Arg110_Ile111del | p.R110_I111del | P68036 | protein_coding | TCGA-CA-6715-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |||
UBE2L3 | SNV | Missense_Mutation | novel | c.571N>T | p.Arg191Cys | p.R191C | P68036 | protein_coding | tolerated(0.06) | benign(0.122) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBE2L3 | SNV | Missense_Mutation | novel | c.609N>T | p.Lys203Asn | p.K203N | P68036 | protein_coding | deleterious(0.03) | possibly_damaging(0.736) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBE2L3 | SNV | Missense_Mutation | novel | c.576N>C | p.Lys192Asn | p.K192N | P68036 | protein_coding | deleterious(0.04) | probably_damaging(0.917) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
UBE2L3 | insertion | Frame_Shift_Ins | novel | c.579dupA | p.Phe194IlefsTer3 | p.F194Ifs*3 | P68036 | protein_coding | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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