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Gene: TYMS |
Gene summary for TYMS |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TYMS | Gene ID | 7298 |
| Gene name | thymidylate synthetase | |
| Gene Alias | HST422 | |
| Cytomap | 18p11.32 | |
| Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P04818 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7298 | TYMS | GSM4909281 | Human | Breast | IDC | 4.26e-13 | 4.04e-01 | 0.21 |
| 7298 | TYMS | GSM4909282 | Human | Breast | IDC | 3.33e-61 | 1.00e+00 | -0.0288 |
| 7298 | TYMS | GSM4909287 | Human | Breast | IDC | 2.16e-23 | 6.13e-01 | 0.2057 |
| 7298 | TYMS | GSM4909288 | Human | Breast | IDC | 5.53e-04 | 4.83e-01 | 0.0988 |
| 7298 | TYMS | M2 | Human | Breast | IDC | 6.15e-03 | 4.18e-01 | 0.21 |
| 7298 | TYMS | HTA11_78_2000001011 | Human | Colorectum | AD | 1.20e-04 | 3.47e-01 | -0.1088 |
| 7298 | TYMS | HTA11_347_2000001011 | Human | Colorectum | AD | 4.99e-02 | 1.87e-01 | -0.1954 |
| 7298 | TYMS | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.91e-03 | 2.74e-01 | -0.059 |
| 7298 | TYMS | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.96e-03 | 2.89e-01 | 0.0131 |
| 7298 | TYMS | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.39e-02 | 3.17e-01 | -0.0177 |
| 7298 | TYMS | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.33e-04 | 2.85e-01 | 0.0588 |
| 7298 | TYMS | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.84e-05 | 2.84e-01 | 0.294 |
| 7298 | TYMS | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.52e-03 | 6.96e-01 | 0.3487 |
| 7298 | TYMS | LZE2T | Human | Esophagus | ESCC | 5.50e-08 | 1.25e+00 | 0.082 |
| 7298 | TYMS | LZE7T | Human | Esophagus | ESCC | 1.43e-02 | 1.44e-01 | 0.0667 |
| 7298 | TYMS | LZE6T | Human | Esophagus | ESCC | 3.94e-02 | 1.23e-01 | 0.0845 |
| 7298 | TYMS | P2T-E | Human | Esophagus | ESCC | 1.28e-24 | 1.51e+00 | 0.1177 |
| 7298 | TYMS | P4T-E | Human | Esophagus | ESCC | 5.39e-32 | 1.12e+00 | 0.1323 |
| 7298 | TYMS | P5T-E | Human | Esophagus | ESCC | 1.20e-42 | 1.24e+00 | 0.1327 |
| 7298 | TYMS | P8T-E | Human | Esophagus | ESCC | 4.87e-07 | 5.17e-01 | 0.0889 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00091421 | Colorectum | SER | nucleoside triphosphate biosynthetic process | 32/2897 | 85/18723 | 5.16e-07 | 2.53e-05 | 32 |
| GO:00096361 | Colorectum | SER | response to toxic substance | 71/2897 | 262/18723 | 8.63e-07 | 4.07e-05 | 71 |
| GO:00610081 | Colorectum | SER | hepaticobiliary system development | 45/2897 | 150/18723 | 4.98e-06 | 1.85e-04 | 45 |
| GO:00018891 | Colorectum | SER | liver development | 44/2897 | 147/18723 | 6.73e-06 | 2.35e-04 | 44 |
| GO:00316671 | Colorectum | SER | response to nutrient levels | 106/2897 | 474/18723 | 3.94e-05 | 1.00e-03 | 106 |
| GO:00485451 | Colorectum | SER | response to steroid hormone | 80/2897 | 339/18723 | 5.15e-05 | 1.25e-03 | 80 |
| GO:00076231 | Colorectum | SER | circadian rhythm | 54/2897 | 210/18723 | 7.98e-05 | 1.77e-03 | 54 |
| GO:00064171 | Colorectum | SER | regulation of translation | 100/2897 | 468/18723 | 3.76e-04 | 5.74e-03 | 100 |
| GO:00974211 | Colorectum | SER | liver regeneration | 14/2897 | 35/18723 | 4.02e-04 | 6.02e-03 | 14 |
| GO:00067301 | Colorectum | SER | one-carbon metabolic process | 15/2897 | 40/18723 | 5.71e-04 | 7.86e-03 | 15 |
| GO:00091651 | Colorectum | SER | nucleotide biosynthetic process | 58/2897 | 254/18723 | 1.21e-03 | 1.38e-02 | 58 |
| GO:19012931 | Colorectum | SER | nucleoside phosphate biosynthetic process | 58/2897 | 256/18723 | 1.47e-03 | 1.59e-02 | 58 |
| GO:00718971 | Colorectum | SER | DNA biosynthetic process | 43/2897 | 180/18723 | 1.99e-03 | 1.98e-02 | 43 |
| GO:0009200 | Colorectum | SER | deoxyribonucleoside triphosphate metabolic process | 8/2897 | 17/18723 | 2.12e-03 | 2.06e-02 | 8 |
| GO:00485111 | Colorectum | SER | rhythmic process | 65/2897 | 298/18723 | 2.18e-03 | 2.11e-02 | 65 |
| GO:19016541 | Colorectum | SER | response to ketone | 44/2897 | 194/18723 | 5.01e-03 | 3.88e-02 | 44 |
| GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
| GO:00020642 | Colorectum | MSS | epithelial cell development | 81/3467 | 220/18723 | 1.02e-10 | 1.06e-08 | 81 |
| GO:00091172 | Colorectum | MSS | nucleotide metabolic process | 144/3467 | 489/18723 | 1.87e-09 | 1.35e-07 | 144 |
| GO:00067532 | Colorectum | MSS | nucleoside phosphate metabolic process | 145/3467 | 497/18723 | 3.25e-09 | 2.23e-07 | 145 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
| hsa002405 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
| hsa015232 | Esophagus | ESCC | Antifolate resistance | 22/4205 | 30/8465 | 7.23e-03 | 1.76e-02 | 8.99e-03 | 22 |
| hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
| hsa0024012 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
| hsa0152311 | Esophagus | ESCC | Antifolate resistance | 22/4205 | 30/8465 | 7.23e-03 | 1.76e-02 | 8.99e-03 | 22 |
| hsa002402 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
| hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
| hsa002403 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
| hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
| hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
| hsa002404 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
| hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
| hsa0024011 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TYMS | SNV | Missense_Mutation | c.604N>C | p.Tyr202His | p.Y202H | P04818 | protein_coding | deleterious(0.03) | possibly_damaging(0.83) | TCGA-EW-A1PD-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | SD | |
| TYMS | insertion | Nonsense_Mutation | novel | c.576_577insGGCTGGAGTGCAGTGGTGTGATCTCCGCTCACGGCAA | p.Pro193GlyfsTer7 | p.P193Gfs*7 | P04818 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
| TYMS | SNV | Missense_Mutation | c.687N>G | p.Ser229Arg | p.S229R | P04818 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
| TYMS | SNV | Missense_Mutation | c.700N>G | p.Thr234Ala | p.T234A | P04818 | protein_coding | deleterious(0.04) | benign(0.356) | TCGA-CA-6719-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| TYMS | SNV | Missense_Mutation | c.197N>A | p.Ser66Asn | p.S66N | P04818 | protein_coding | tolerated(0.37) | benign(0.003) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TYMS | SNV | Missense_Mutation | c.527N>A | p.Arg176Lys | p.R176K | P04818 | protein_coding | deleterious(0) | possibly_damaging(0.805) | TCGA-AH-6544-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
| TYMS | deletion | Frame_Shift_Del | c.486_487delAA | p.Arg163SerfsTer3 | p.R163Sfs*3 | P04818 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| TYMS | SNV | Missense_Mutation | novel | c.724N>A | p.Gly242Ser | p.G242S | P04818 | protein_coding | deleterious(0.02) | benign(0.395) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
| TYMS | SNV | Missense_Mutation | novel | c.233G>A | p.Arg78His | p.R78H | P04818 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
| TYMS | SNV | Missense_Mutation | novel | c.369C>A | p.Phe123Leu | p.F123L | P04818 | protein_coding | tolerated(1) | benign(0.017) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 7298 | TYMS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, DRUG RESISTANCE | inhibitor | CHEMBL1200373 | ||
| 7298 | TYMS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, DRUG RESISTANCE | CAPECITABINE | CAPECITABINE | ||
| 7298 | TYMS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, DRUG RESISTANCE | OSI-7904L | OSI-7904 | ||
| 7298 | TYMS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, DRUG RESISTANCE | irinotecan | IRINOTECAN | 21273624,16456808 | |
| 7298 | TYMS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, DRUG RESISTANCE | HYDROCORTISONE | HYDROCORTISONE | 2707640 | |
| 7298 | TYMS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, DRUG RESISTANCE | METHOTREXATE | METHOTREXATE | 23652803 | |
| 7298 | TYMS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, DRUG RESISTANCE | FLUOROURACIL | FLUOROURACIL | 24450514 | |
| 7298 | TYMS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, DRUG RESISTANCE | TEGAFUR | TEGAFUR | ||
| 7298 | TYMS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, DRUG RESISTANCE | PEMETREXED | PEMETREXED | ||
| 7298 | TYMS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE, DRUG RESISTANCE | INDOMETHACIN | INDOMETHACIN | 2707640 |
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