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Gene: TYMP |
Gene summary for TYMP |
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Gene information | Species | Human | Gene symbol | TYMP | Gene ID | 1890 |
Gene name | thymidine phosphorylase | |
Gene Alias | ECGF | |
Cytomap | 22q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000002 | UniProtAcc | B2RBL3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1890 | TYMP | GSM4909285 | Human | Breast | IDC | 1.67e-05 | -3.49e-01 | 0.21 |
1890 | TYMP | GSM4909286 | Human | Breast | IDC | 3.23e-26 | -5.84e-01 | 0.1081 |
1890 | TYMP | GSM4909290 | Human | Breast | IDC | 1.01e-08 | 5.28e-01 | 0.2096 |
1890 | TYMP | GSM4909293 | Human | Breast | IDC | 2.39e-04 | -2.31e-01 | 0.1581 |
1890 | TYMP | GSM4909296 | Human | Breast | IDC | 2.89e-26 | -5.51e-01 | 0.1524 |
1890 | TYMP | GSM4909297 | Human | Breast | IDC | 1.38e-11 | -2.52e-01 | 0.1517 |
1890 | TYMP | GSM4909298 | Human | Breast | IDC | 1.95e-17 | -5.10e-01 | 0.1551 |
1890 | TYMP | GSM4909299 | Human | Breast | IDC | 6.11e-03 | -2.03e-01 | 0.035 |
1890 | TYMP | GSM4909301 | Human | Breast | IDC | 1.85e-02 | -2.74e-01 | 0.1577 |
1890 | TYMP | GSM4909302 | Human | Breast | IDC | 2.16e-02 | -2.85e-01 | 0.1545 |
1890 | TYMP | GSM4909311 | Human | Breast | IDC | 1.28e-31 | -4.24e-01 | 0.1534 |
1890 | TYMP | GSM4909312 | Human | Breast | IDC | 3.69e-14 | -3.38e-01 | 0.1552 |
1890 | TYMP | GSM4909315 | Human | Breast | IDC | 4.31e-06 | -3.59e-01 | 0.21 |
1890 | TYMP | GSM4909319 | Human | Breast | IDC | 3.65e-33 | -2.55e-01 | 0.1563 |
1890 | TYMP | GSM4909321 | Human | Breast | IDC | 3.71e-11 | 2.92e-01 | 0.1559 |
1890 | TYMP | brca1 | Human | Breast | Precancer | 6.78e-24 | 7.23e-01 | -0.0338 |
1890 | TYMP | brca2 | Human | Breast | Precancer | 1.40e-25 | 6.44e-01 | -0.024 |
1890 | TYMP | brca3 | Human | Breast | Precancer | 2.33e-18 | 4.98e-01 | -0.0263 |
1890 | TYMP | NCCBC14 | Human | Breast | DCIS | 4.00e-02 | -3.33e-02 | 0.2021 |
1890 | TYMP | NCCBC5 | Human | Breast | DCIS | 5.94e-21 | 4.86e-01 | 0.2046 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091234 | Esophagus | ESCC | nucleoside monophosphate metabolic process | 49/8552 | 76/18723 | 7.30e-04 | 3.80e-03 | 49 |
GO:000926212 | Esophagus | ESCC | deoxyribonucleotide metabolic process | 31/8552 | 44/18723 | 7.70e-04 | 3.99e-03 | 31 |
GO:00725273 | Esophagus | ESCC | pyrimidine-containing compound metabolic process | 52/8552 | 82/18723 | 9.03e-04 | 4.61e-03 | 52 |
GO:00091124 | Esophagus | ESCC | nucleobase metabolic process | 25/8552 | 34/18723 | 9.19e-04 | 4.68e-03 | 25 |
GO:00000021 | Esophagus | ESCC | mitochondrial genome maintenance | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
GO:19011362 | Esophagus | ESCC | carbohydrate derivative catabolic process | 99/8552 | 172/18723 | 1.11e-03 | 5.54e-03 | 99 |
GO:001969212 | Esophagus | ESCC | deoxyribose phosphate metabolic process | 29/8552 | 42/18723 | 1.87e-03 | 8.46e-03 | 29 |
GO:0031641 | Esophagus | ESCC | regulation of myelination | 31/8552 | 47/18723 | 4.01e-03 | 1.62e-02 | 31 |
GO:000939412 | Esophagus | ESCC | 2'-deoxyribonucleotide metabolic process | 27/8552 | 40/18723 | 4.39e-03 | 1.73e-02 | 27 |
GO:00091163 | Esophagus | ESCC | nucleoside metabolic process | 39/8552 | 62/18723 | 4.68e-03 | 1.82e-02 | 39 |
GO:000921912 | Esophagus | ESCC | pyrimidine deoxyribonucleotide metabolic process | 17/8552 | 24/18723 | 1.13e-02 | 3.81e-02 | 17 |
GO:190136111 | Liver | Cirrhotic | organic cyclic compound catabolic process | 213/4634 | 495/18723 | 1.58e-19 | 3.67e-17 | 213 |
GO:001943911 | Liver | Cirrhotic | aromatic compound catabolic process | 202/4634 | 467/18723 | 6.93e-19 | 1.28e-16 | 202 |
GO:004427011 | Liver | Cirrhotic | cellular nitrogen compound catabolic process | 195/4634 | 451/18723 | 2.99e-18 | 4.94e-16 | 195 |
GO:004670011 | Liver | Cirrhotic | heterocycle catabolic process | 192/4634 | 445/18723 | 7.17e-18 | 1.12e-15 | 192 |
GO:003465511 | Liver | Cirrhotic | nucleobase-containing compound catabolic process | 171/4634 | 407/18723 | 9.07e-15 | 9.33e-13 | 171 |
GO:000675312 | Liver | Cirrhotic | nucleoside phosphate metabolic process | 190/4634 | 497/18723 | 1.10e-11 | 6.96e-10 | 190 |
GO:000911712 | Liver | Cirrhotic | nucleotide metabolic process | 187/4634 | 489/18723 | 1.55e-11 | 9.63e-10 | 187 |
GO:00091232 | Liver | Cirrhotic | nucleoside monophosphate metabolic process | 36/4634 | 76/18723 | 1.55e-05 | 2.11e-04 | 36 |
GO:00091121 | Liver | Cirrhotic | nucleobase metabolic process | 20/4634 | 34/18723 | 2.41e-05 | 3.14e-04 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052196 | Breast | Precancer | Bladder cancer | 9/684 | 41/8465 | 4.65e-03 | 2.72e-02 | 2.08e-02 | 9 |
hsa0521913 | Breast | Precancer | Bladder cancer | 9/684 | 41/8465 | 4.65e-03 | 2.72e-02 | 2.08e-02 | 9 |
hsa0521921 | Breast | IDC | Bladder cancer | 10/867 | 41/8465 | 7.07e-03 | 3.54e-02 | 2.65e-02 | 10 |
hsa0521931 | Breast | IDC | Bladder cancer | 10/867 | 41/8465 | 7.07e-03 | 3.54e-02 | 2.65e-02 | 10 |
hsa0521941 | Breast | DCIS | Bladder cancer | 10/846 | 41/8465 | 5.96e-03 | 3.01e-02 | 2.21e-02 | 10 |
hsa0521951 | Breast | DCIS | Bladder cancer | 10/846 | 41/8465 | 5.96e-03 | 3.01e-02 | 2.21e-02 | 10 |
hsa052197 | Cervix | CC | Bladder cancer | 16/1267 | 41/8465 | 1.45e-04 | 9.05e-04 | 5.35e-04 | 16 |
hsa0521914 | Cervix | CC | Bladder cancer | 16/1267 | 41/8465 | 1.45e-04 | 9.05e-04 | 5.35e-04 | 16 |
hsa0521910 | Esophagus | ESCC | Bladder cancer | 35/4205 | 41/8465 | 1.91e-06 | 1.15e-05 | 5.87e-06 | 35 |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa002405 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa0521917 | Esophagus | ESCC | Bladder cancer | 35/4205 | 41/8465 | 1.91e-06 | 1.15e-05 | 5.87e-06 | 35 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0024012 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa052194 | Liver | Cirrhotic | Bladder cancer | 25/2530 | 41/8465 | 3.48e-05 | 2.57e-04 | 1.59e-04 | 25 |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa00240 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa00983 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa0521911 | Liver | Cirrhotic | Bladder cancer | 25/2530 | 41/8465 | 3.48e-05 | 2.57e-04 | 1.59e-04 | 25 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TYMP | SNV | Missense_Mutation | novel | c.293C>G | p.Ser98Trp | p.S98W | P19971 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | SD | |
TYMP | SNV | Missense_Mutation | rs776356925 | c.196N>A | p.Ala66Thr | p.A66T | P19971 | protein_coding | tolerated(0.11) | possibly_damaging(0.649) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TYMP | SNV | Missense_Mutation | rs768461642 | c.151N>A | p.Glu51Lys | p.E51K | P19971 | protein_coding | tolerated(0.55) | benign(0.007) | TCGA-C5-A3HD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
TYMP | SNV | Missense_Mutation | rs201513101 | c.316G>C | p.Glu106Gln | p.E106Q | P19971 | protein_coding | tolerated(0.15) | benign(0.037) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TYMP | SNV | Missense_Mutation | c.426G>A | p.Met142Ile | p.M142I | P19971 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TYMP | SNV | Missense_Mutation | novel | c.581N>T | p.Ala194Val | p.A194V | P19971 | protein_coding | deleterious(0.02) | probably_damaging(0.974) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TYMP | SNV | Missense_Mutation | novel | c.239N>G | p.Leu80Arg | p.L80R | P19971 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TYMP | SNV | Missense_Mutation | c.383T>A | p.Val128Asp | p.V128D | P19971 | protein_coding | deleterious(0.01) | probably_damaging(0.91) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
TYMP | SNV | Missense_Mutation | c.413N>T | p.Cys138Phe | p.C138F | P19971 | protein_coding | tolerated(0.11) | probably_damaging(1) | TCGA-DM-A28C-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TYMP | SNV | Missense_Mutation | c.249N>T | p.Met83Ile | p.M83I | P19971 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1890 | TYMP | GROWTH FACTOR, DRUGGABLE GENOME | FLUOROURACIL | FLUOROURACIL | 11205264 | |
1890 | TYMP | GROWTH FACTOR, DRUGGABLE GENOME | S-1 | 16685374 | ||
1890 | TYMP | GROWTH FACTOR, DRUGGABLE GENOME | fluorouracil | FLUOROURACIL | 24167597 | |
1890 | TYMP | GROWTH FACTOR, DRUGGABLE GENOME | capecitabine | CAPECITABINE | 24167597 | |
1890 | TYMP | GROWTH FACTOR, DRUGGABLE GENOME | inhibitor | CHEMBL65375 | TIPIRACIL HYDROCHLORIDE | |
1890 | TYMP | GROWTH FACTOR, DRUGGABLE GENOME | MPA | PROGESTERONE | 12711006 | |
1890 | TYMP | GROWTH FACTOR, DRUGGABLE GENOME | SULFASALAZINE | SULFASALAZINE | 15269287 | |
1890 | TYMP | GROWTH FACTOR, DRUGGABLE GENOME | Uridine | URIDINE | ||
1890 | TYMP | GROWTH FACTOR, DRUGGABLE GENOME | 5-DEOXY-5-FLUOROURIDINE | 11956613 |
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