Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TTC17

Gene summary for TTC17

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TTC17

Gene ID

55761

Gene nametetratricopeptide repeat domain 17
Gene AliasTTC17
Cytomap11p12-p11.2
Gene Typeprotein-coding
GO ID

GO:0006996

UniProtAcc

Q6MZP1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
55761TTC17CCI_2HumanCervixCC2.09e-037.80e-010.5249
55761TTC17CCI_3HumanCervixCC3.39e-097.30e-010.516
55761TTC17HTA11_3410_2000001011HumanColorectumAD1.48e-32-7.73e-010.0155
55761TTC17HTA11_2487_2000001011HumanColorectumSER1.30e-10-6.91e-01-0.1808
55761TTC17HTA11_2951_2000001011HumanColorectumAD7.49e-08-9.50e-010.0216
55761TTC17HTA11_2112_2000001011HumanColorectumSER6.04e-04-6.76e-01-0.2196
55761TTC17HTA11_3361_2000001011HumanColorectumAD6.37e-16-8.97e-01-0.1207
55761TTC17HTA11_83_2000001011HumanColorectumSER2.15e-03-5.43e-01-0.1526
55761TTC17HTA11_696_2000001011HumanColorectumAD8.94e-16-5.54e-01-0.1464
55761TTC17HTA11_866_2000001011HumanColorectumAD1.97e-03-3.42e-01-0.1001
55761TTC17HTA11_5212_2000001011HumanColorectumAD9.98e-09-8.08e-01-0.2061
55761TTC17HTA11_5216_2000001011HumanColorectumSER5.95e-05-7.95e-01-0.1462
55761TTC17HTA11_9341_2000001011HumanColorectumSER4.74e-04-7.16e-01-0.00410000000000005
55761TTC17HTA11_7862_2000001011HumanColorectumAD7.64e-04-4.91e-01-0.0179
55761TTC17HTA11_866_3004761011HumanColorectumAD2.11e-19-7.49e-010.096
55761TTC17HTA11_9408_2000001011HumanColorectumAD1.33e-03-8.81e-010.0451
55761TTC17HTA11_8622_2000001021HumanColorectumSER1.91e-12-8.83e-010.0528
55761TTC17HTA11_6801_2000001011HumanColorectumSER3.39e-02-5.94e-010.0171
55761TTC17HTA11_10711_2000001011HumanColorectumAD3.43e-10-5.93e-010.0338
55761TTC17HTA11_7696_3000711011HumanColorectumAD5.73e-10-4.78e-010.0674
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:003004119Oral cavityLPactin filament polymerization69/4623191/187232.65e-042.75e-0369
GO:000815419Oral cavityLPactin polymerization or depolymerization76/4623218/187234.67e-044.42e-0376
GO:000701526Oral cavityEOLPactin filament organization102/2218442/187231.61e-112.48e-09102
GO:005125825Oral cavityEOLPprotein polymerization74/2218297/187232.65e-102.45e-0874
GO:000815424Oral cavityEOLPactin polymerization or depolymerization53/2218218/187232.08e-076.55e-0653
GO:003004123Oral cavityEOLPactin filament polymerization48/2218191/187232.68e-078.16e-0648
GO:000701534Oral cavityNEOLPactin filament organization94/2005442/187234.49e-115.80e-0994
GO:005125833Oral cavityNEOLPprotein polymerization67/2005297/187232.27e-091.40e-0767
GO:000815431Oral cavityNEOLPactin polymerization or depolymerization47/2005218/187232.11e-064.91e-0547
GO:003004132Oral cavityNEOLPactin filament polymerization41/2005191/187231.03e-051.94e-0441
GO:000701518ProstateBPHactin filament organization147/3107442/187233.36e-181.15e-15147
GO:005125818ProstateBPHprotein polymerization96/3107297/187231.52e-111.10e-0996
GO:000815416ProstateBPHactin polymerization or depolymerization72/3107218/187231.82e-097.59e-0872
GO:003004116ProstateBPHactin filament polymerization63/3107191/187231.94e-085.98e-0763
GO:000701519ProstateTumoractin filament organization142/3246442/187231.40e-141.89e-12142
GO:005125819ProstateTumorprotein polymerization93/3246297/187232.22e-099.58e-0893
GO:000815417ProstateTumoractin polymerization or depolymerization70/3246218/187236.91e-081.97e-0670
GO:003004117ProstateTumoractin filament polymerization62/3246191/187232.47e-075.72e-0662
GO:000701528SkinAKactin filament organization85/1910442/187235.94e-094.14e-0785
GO:005125827SkinAKprotein polymerization53/1910297/187233.74e-056.20e-0453
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TTC17SNVMissense_Mutationnovelc.2908G>Tp.Ala970Serp.A970SQ96AE7protein_codingtolerated(0.38)possibly_damaging(0.551)TCGA-A2-A25A-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificCytoxanSD
TTC17SNVMissense_Mutationnovelc.3082A>Gp.Lys1028Glup.K1028EQ96AE7protein_codingtolerated(0.18)probably_damaging(0.98)TCGA-A2-A3XY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinPD
TTC17SNVMissense_Mutationc.2881G>Tp.Asp961Tyrp.D961YQ96AE7protein_codingdeleterious(0)probably_damaging(0.997)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
TTC17SNVMissense_Mutationc.412N>Tp.Asp138Tyrp.D138YQ96AE7protein_codingdeleterious(0.02)possibly_damaging(0.736)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TTC17SNVMissense_Mutationnovelc.3080N>Gp.Val1027Glyp.V1027GQ96AE7protein_codingdeleterious(0)probably_damaging(0.991)TCGA-AO-A1KP-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapyfluorouracilSD
TTC17SNVMissense_Mutationc.1552G>Ap.Glu518Lysp.E518KQ96AE7protein_codingtolerated(0.58)benign(0.106)TCGA-AR-A251-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicinSD
TTC17SNVMissense_Mutationc.334N>Tp.Pro112Serp.P112SQ96AE7protein_codingtolerated(0.28)benign(0.34)TCGA-BH-A18G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TTC17SNVMissense_Mutationc.751N>Gp.Arg251Glyp.R251GQ96AE7protein_codingdeleterious(0)probably_damaging(0.953)TCGA-C8-A134-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
TTC17SNVMissense_Mutationrs765970018c.1429N>Ap.Val477Ilep.V477IQ96AE7protein_codingtolerated(0.39)benign(0.06)TCGA-EW-A1IZ-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapytaxotereSD
TTC17insertionFrame_Shift_Insnovelc.2137_2138insTATTATATATTAGTCTTTTp.Arg713IlefsTer20p.R713Ifs*20Q96AE7protein_codingTCGA-A8-A07L-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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