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Gene: TMEM79 |
Gene summary for TMEM79 |
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Gene information | Species | Human | Gene symbol | TMEM79 | Gene ID | 84283 |
Gene name | transmembrane protein 79 | |
Gene Alias | MATT | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0001942 | UniProtAcc | Q9BSE2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84283 | TMEM79 | LZE24T | Human | Esophagus | ESCC | 1.05e-02 | 8.53e-02 | 0.0596 |
84283 | TMEM79 | P2T-E | Human | Esophagus | ESCC | 1.87e-06 | 7.37e-02 | 0.1177 |
84283 | TMEM79 | P4T-E | Human | Esophagus | ESCC | 7.97e-12 | 2.64e-01 | 0.1323 |
84283 | TMEM79 | P5T-E | Human | Esophagus | ESCC | 1.36e-18 | 1.30e-01 | 0.1327 |
84283 | TMEM79 | P8T-E | Human | Esophagus | ESCC | 9.95e-15 | 1.90e-01 | 0.0889 |
84283 | TMEM79 | P9T-E | Human | Esophagus | ESCC | 3.84e-03 | 2.97e-02 | 0.1131 |
84283 | TMEM79 | P10T-E | Human | Esophagus | ESCC | 1.21e-07 | 1.82e-01 | 0.116 |
84283 | TMEM79 | P12T-E | Human | Esophagus | ESCC | 1.81e-07 | 1.81e-01 | 0.1122 |
84283 | TMEM79 | P15T-E | Human | Esophagus | ESCC | 2.68e-10 | 2.20e-01 | 0.1149 |
84283 | TMEM79 | P16T-E | Human | Esophagus | ESCC | 1.11e-08 | 7.47e-02 | 0.1153 |
84283 | TMEM79 | P17T-E | Human | Esophagus | ESCC | 4.74e-04 | 2.20e-01 | 0.1278 |
84283 | TMEM79 | P20T-E | Human | Esophagus | ESCC | 1.40e-14 | 2.32e-01 | 0.1124 |
84283 | TMEM79 | P21T-E | Human | Esophagus | ESCC | 1.73e-15 | 2.85e-01 | 0.1617 |
84283 | TMEM79 | P22T-E | Human | Esophagus | ESCC | 5.10e-18 | 1.77e-01 | 0.1236 |
84283 | TMEM79 | P23T-E | Human | Esophagus | ESCC | 2.72e-07 | 1.28e-01 | 0.108 |
84283 | TMEM79 | P24T-E | Human | Esophagus | ESCC | 8.42e-09 | 3.11e-01 | 0.1287 |
84283 | TMEM79 | P26T-E | Human | Esophagus | ESCC | 2.65e-14 | 3.09e-01 | 0.1276 |
84283 | TMEM79 | P27T-E | Human | Esophagus | ESCC | 2.54e-14 | 3.38e-01 | 0.1055 |
84283 | TMEM79 | P28T-E | Human | Esophagus | ESCC | 1.32e-11 | 3.40e-01 | 0.1149 |
84283 | TMEM79 | P30T-E | Human | Esophagus | ESCC | 4.55e-02 | 2.04e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240421 | Skin | cSCC | molting cycle process | 36/4864 | 84/18723 | 5.64e-04 | 4.12e-03 | 36 |
GO:002240521 | Skin | cSCC | hair cycle process | 36/4864 | 84/18723 | 5.64e-04 | 4.12e-03 | 36 |
GO:004568215 | Skin | cSCC | regulation of epidermis development | 28/4864 | 65/18723 | 2.02e-03 | 1.20e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM79 | SNV | Missense_Mutation | c.896N>T | p.Ala299Val | p.A299V | Q9BSE2 | protein_coding | tolerated(0.11) | possibly_damaging(0.781) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM79 | SNV | Missense_Mutation | c.178G>C | p.Glu60Gln | p.E60Q | Q9BSE2 | protein_coding | tolerated(0.08) | benign(0.361) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TMEM79 | SNV | Missense_Mutation | rs762068186 | c.658N>A | p.Ala220Thr | p.A220T | Q9BSE2 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-Z7-A8R5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
TMEM79 | SNV | Missense_Mutation | novel | c.1021N>A | p.Gly341Ser | p.G341S | Q9BSE2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM79 | SNV | Missense_Mutation | rs748534614 | c.890N>G | p.Asn297Ser | p.N297S | Q9BSE2 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM79 | SNV | Missense_Mutation | c.979N>C | p.Tyr327His | p.Y327H | Q9BSE2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3975-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMEM79 | SNV | Missense_Mutation | c.172G>T | p.Ala58Ser | p.A58S | Q9BSE2 | protein_coding | tolerated(0.05) | benign(0.168) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TMEM79 | SNV | Missense_Mutation | novel | c.891C>G | p.Asn297Lys | p.N297K | Q9BSE2 | protein_coding | deleterious(0.01) | probably_damaging(0.946) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM79 | SNV | Missense_Mutation | rs750729853 | c.610G>A | p.Val204Met | p.V204M | Q9BSE2 | protein_coding | tolerated(0.41) | benign(0.024) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
TMEM79 | SNV | Missense_Mutation | rs151038552 | c.343G>A | p.Glu115Lys | p.E115K | Q9BSE2 | protein_coding | tolerated(0.16) | benign(0.015) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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