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Gene: TLK1 |
Gene summary for TLK1 |
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Gene information | Species | Human | Gene symbol | TLK1 | Gene ID | 9874 |
Gene name | tousled like kinase 1 | |
Gene Alias | PKU-beta | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0001672 | UniProtAcc | Q9UKI8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9874 | TLK1 | CA_HPV_1 | Human | Cervix | CC | 4.78e-08 | 1.47e-02 | 0.0264 |
9874 | TLK1 | CCI_2 | Human | Cervix | CC | 5.72e-05 | 7.72e-01 | 0.5249 |
9874 | TLK1 | CCI_3 | Human | Cervix | CC | 1.14e-03 | 7.14e-01 | 0.516 |
9874 | TLK1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.77e-23 | -6.62e-01 | 0.0155 |
9874 | TLK1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.94e-03 | -7.39e-01 | 0.0216 |
9874 | TLK1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.50e-02 | 3.56e-01 | -0.2602 |
9874 | TLK1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.11e-05 | -5.73e-01 | -0.1207 |
9874 | TLK1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.13e-03 | -3.29e-01 | -0.1464 |
9874 | TLK1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.14e-04 | -6.65e-01 | -0.2061 |
9874 | TLK1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.25e-02 | -6.07e-01 | -0.1462 |
9874 | TLK1 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.57e-16 | -6.42e-01 | 0.096 |
9874 | TLK1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 5.36e-03 | -8.13e-01 | 0.0451 |
9874 | TLK1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.21e-07 | -8.01e-01 | 0.0528 |
9874 | TLK1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.50e-11 | -6.35e-01 | 0.0338 |
9874 | TLK1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.15e-15 | -5.44e-01 | 0.0674 |
9874 | TLK1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 7.71e-04 | -6.22e-01 | 0.0112 |
9874 | TLK1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.06e-04 | -4.12e-01 | 0.294 |
9874 | TLK1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.15e-13 | -6.01e-01 | 0.3859 |
9874 | TLK1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.94e-12 | -7.39e-01 | 0.2585 |
9874 | TLK1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.49e-21 | -6.79e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001820923 | Skin | cSCC | peptidyl-serine modification | 108/4864 | 338/18723 | 7.73e-03 | 3.60e-02 | 108 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:001810518 | Thyroid | PTC | peptidyl-serine phosphorylation | 143/5968 | 315/18723 | 2.94e-07 | 5.04e-06 | 143 |
GO:001820916 | Thyroid | PTC | peptidyl-serine modification | 151/5968 | 338/18723 | 4.61e-07 | 7.51e-06 | 151 |
GO:00070595 | Thyroid | PTC | chromosome segregation | 146/5968 | 346/18723 | 2.99e-05 | 2.87e-04 | 146 |
GO:000705913 | Thyroid | ATC | chromosome segregation | 183/6293 | 346/18723 | 8.03e-14 | 4.23e-12 | 183 |
GO:001810519 | Thyroid | ATC | peptidyl-serine phosphorylation | 153/6293 | 315/18723 | 2.28e-08 | 4.42e-07 | 153 |
GO:001820917 | Thyroid | ATC | peptidyl-serine modification | 161/6293 | 338/18723 | 5.23e-08 | 9.44e-07 | 161 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TLK1 | SNV | Missense_Mutation | c.1331C>T | p.Ser444Leu | p.S444L | Q9UKI8 | protein_coding | deleterious(0.01) | possibly_damaging(0.83) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
TLK1 | SNV | Missense_Mutation | c.181N>A | p.Glu61Lys | p.E61K | Q9UKI8 | protein_coding | deleterious_low_confidence(0) | benign(0.125) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TLK1 | SNV | Missense_Mutation | novel | c.791N>C | p.Lys264Thr | p.K264T | Q9UKI8 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TLK1 | SNV | Missense_Mutation | c.274N>A | p.Glu92Lys | p.E92K | Q9UKI8 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TLK1 | SNV | Missense_Mutation | novel | c.1285A>C | p.Asn429His | p.N429H | Q9UKI8 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-D8-A3Z5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TLK1 | SNV | Missense_Mutation | novel | c.1619A>T | p.Tyr540Phe | p.Y540F | Q9UKI8 | protein_coding | tolerated(0.11) | benign(0.084) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TLK1 | SNV | Missense_Mutation | c.274N>A | p.Glu92Lys | p.E92K | Q9UKI8 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TLK1 | SNV | Missense_Mutation | c.817A>C | p.Met273Leu | p.M273L | Q9UKI8 | protein_coding | tolerated(0.15) | probably_damaging(0.925) | TCGA-EA-A411-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TLK1 | SNV | Missense_Mutation | c.2191N>T | p.Asp731Tyr | p.D731Y | Q9UKI8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TLK1 | SNV | Missense_Mutation | novel | c.1009G>A | p.Glu337Lys | p.E337K | Q9UKI8 | protein_coding | tolerated(0.07) | probably_damaging(0.995) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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