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Gene: TIMM10 |
Gene summary for TIMM10 |
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Gene information | Species | Human | Gene symbol | TIMM10 | Gene ID | 26519 |
Gene name | translocase of inner mitochondrial membrane 10 | |
Gene Alias | TIM10 | |
Cytomap | 11q12.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | P62072 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26519 | TIMM10 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.88e-03 | 1.14e-01 | 0.0155 |
26519 | TIMM10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.67e-05 | 2.45e-01 | -0.1808 |
26519 | TIMM10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.33e-07 | 3.25e-01 | -0.0811 |
26519 | TIMM10 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.08e-03 | 1.64e-01 | -0.1954 |
26519 | TIMM10 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.45e-06 | 3.30e-01 | -0.1526 |
26519 | TIMM10 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.03e-09 | 2.27e-01 | -0.1464 |
26519 | TIMM10 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.86e-11 | 2.62e-01 | -0.1001 |
26519 | TIMM10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.50e-08 | 3.05e-01 | -0.059 |
26519 | TIMM10 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.49e-12 | 3.71e-01 | 0.096 |
26519 | TIMM10 | HTA11_8622_2000001021 | Human | Colorectum | SER | 7.63e-03 | 3.22e-01 | 0.0528 |
26519 | TIMM10 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.93e-03 | 3.79e-01 | 0.0131 |
26519 | TIMM10 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.50e-04 | 3.54e-01 | 0.0171 |
26519 | TIMM10 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.33e-02 | 1.79e-01 | 0.0338 |
26519 | TIMM10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.82e-13 | 2.50e-01 | 0.0674 |
26519 | TIMM10 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.24e-02 | 3.28e-01 | -0.0124 |
26519 | TIMM10 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.73e-12 | 2.64e-01 | 0.294 |
26519 | TIMM10 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.74e-03 | 1.98e-01 | 0.281 |
26519 | TIMM10 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.10e-17 | 3.72e-01 | 0.3859 |
26519 | TIMM10 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.71e-06 | 1.77e-01 | 0.3005 |
26519 | TIMM10 | LZE2D | Human | Esophagus | HGIN | 3.57e-03 | 3.60e-01 | 0.0642 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000700713 | Esophagus | ESCC | inner mitochondrial membrane organization | 31/8552 | 38/18723 | 5.93e-06 | 6.10e-05 | 31 |
GO:005120416 | Esophagus | ESCC | protein insertion into mitochondrial membrane | 21/8552 | 25/18723 | 9.12e-05 | 6.54e-04 | 21 |
GO:00450393 | Esophagus | ESCC | protein insertion into mitochondrial inner membrane | 11/8552 | 12/18723 | 1.26e-03 | 6.06e-03 | 11 |
GO:007259412 | Liver | Cirrhotic | establishment of protein localization to organelle | 189/4634 | 422/18723 | 1.01e-19 | 2.45e-17 | 189 |
GO:00066057 | Liver | Cirrhotic | protein targeting | 148/4634 | 314/18723 | 3.86e-18 | 6.20e-16 | 148 |
GO:00901507 | Liver | Cirrhotic | establishment of protein localization to membrane | 123/4634 | 260/18723 | 1.85e-15 | 2.15e-13 | 123 |
GO:00068397 | Liver | Cirrhotic | mitochondrial transport | 112/4634 | 254/18723 | 1.03e-11 | 6.66e-10 | 112 |
GO:00705857 | Liver | Cirrhotic | protein localization to mitochondrion | 65/4634 | 125/18723 | 4.91e-11 | 2.77e-09 | 65 |
GO:00726557 | Liver | Cirrhotic | establishment of protein localization to mitochondrion | 63/4634 | 120/18723 | 5.70e-11 | 3.19e-09 | 63 |
GO:00066267 | Liver | Cirrhotic | protein targeting to mitochondrion | 53/4634 | 100/18723 | 1.19e-09 | 5.27e-08 | 53 |
GO:00070065 | Liver | Cirrhotic | mitochondrial membrane organization | 57/4634 | 116/18723 | 1.13e-08 | 4.29e-07 | 57 |
GO:003158912 | Liver | Cirrhotic | cell-substrate adhesion | 128/4634 | 363/18723 | 4.10e-06 | 6.90e-05 | 128 |
GO:00901515 | Liver | Cirrhotic | establishment of protein localization to mitochondrial membrane | 19/4634 | 30/18723 | 8.57e-06 | 1.27e-04 | 19 |
GO:00512053 | Liver | Cirrhotic | protein insertion into membrane | 29/4634 | 57/18723 | 1.88e-05 | 2.53e-04 | 29 |
GO:00512044 | Liver | Cirrhotic | protein insertion into mitochondrial membrane | 16/4634 | 25/18723 | 3.72e-05 | 4.47e-04 | 16 |
GO:000716011 | Liver | Cirrhotic | cell-matrix adhesion | 85/4634 | 233/18723 | 4.06e-05 | 4.83e-04 | 85 |
GO:00070073 | Liver | Cirrhotic | inner mitochondrial membrane organization | 19/4634 | 38/18723 | 6.75e-04 | 5.06e-03 | 19 |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:000660512 | Liver | HCC | protein targeting | 219/7958 | 314/18723 | 7.74e-23 | 1.49e-20 | 219 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIMM10 | SNV | Missense_Mutation | c.260N>G | p.Ser87Cys | p.S87C | P62072 | protein_coding | deleterious(0.03) | benign(0.077) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
TIMM10 | SNV | Missense_Mutation | novel | c.13N>G | p.Arg5Gly | p.R5G | P62072 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TIMM10 | SNV | Missense_Mutation | novel | c.55N>A | p.Ala19Thr | p.A19T | P62072 | protein_coding | tolerated(1) | benign(0.057) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TIMM10 | SNV | Missense_Mutation | c.196G>T | p.Gly66Cys | p.G66C | P62072 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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