GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604917 | Oral cavity | OSCC | cell growth | 268/7305 | 482/18723 | 6.55e-14 | 3.51e-12 | 268 |
GO:000155816 | Oral cavity | OSCC | regulation of cell growth | 228/7305 | 414/18723 | 1.74e-11 | 6.09e-10 | 228 |
GO:19019905 | Oral cavity | OSCC | regulation of mitotic cell cycle phase transition | 173/7305 | 299/18723 | 2.49e-11 | 8.35e-10 | 173 |
GO:000704416 | Oral cavity | OSCC | cell-substrate junction assembly | 67/7305 | 95/18723 | 4.51e-10 | 1.19e-08 | 67 |
GO:015011517 | Oral cavity | OSCC | cell-substrate junction organization | 70/7305 | 101/18723 | 6.36e-10 | 1.63e-08 | 70 |
GO:19019875 | Oral cavity | OSCC | regulation of cell cycle phase transition | 209/7305 | 390/18723 | 2.79e-09 | 6.42e-08 | 209 |
GO:00457864 | Oral cavity | OSCC | negative regulation of cell cycle | 206/7305 | 385/18723 | 4.28e-09 | 9.55e-08 | 206 |
GO:003109816 | Oral cavity | OSCC | stress-activated protein kinase signaling cascade | 141/7305 | 247/18723 | 5.74e-09 | 1.25e-07 | 141 |
GO:003297020 | Oral cavity | OSCC | regulation of actin filament-based process | 209/7305 | 397/18723 | 1.89e-08 | 3.72e-07 | 209 |
GO:003158917 | Oral cavity | OSCC | cell-substrate adhesion | 193/7305 | 363/18723 | 2.48e-08 | 4.82e-07 | 193 |
GO:00000753 | Oral cavity | OSCC | cell cycle checkpoint | 101/7305 | 169/18723 | 3.53e-08 | 6.68e-07 | 101 |
GO:00070933 | Oral cavity | OSCC | mitotic cell cycle checkpoint | 81/7305 | 129/18723 | 3.75e-08 | 7.06e-07 | 81 |
GO:004804110 | Oral cavity | OSCC | focal adhesion assembly | 59/7305 | 87/18723 | 4.86e-08 | 8.95e-07 | 59 |
GO:00427707 | Oral cavity | OSCC | signal transduction in response to DNA damage | 102/7305 | 172/18723 | 5.27e-08 | 9.68e-07 | 102 |
GO:005140316 | Oral cavity | OSCC | stress-activated MAPK cascade | 134/7305 | 239/18723 | 6.02e-08 | 1.09e-06 | 134 |
GO:00459304 | Oral cavity | OSCC | negative regulation of mitotic cell cycle | 132/7305 | 235/18723 | 6.51e-08 | 1.16e-06 | 132 |
GO:003295620 | Oral cavity | OSCC | regulation of actin cytoskeleton organization | 189/7305 | 358/18723 | 6.81e-08 | 1.21e-06 | 189 |
GO:00000863 | Oral cavity | OSCC | G2/M transition of mitotic cell cycle | 84/7305 | 137/18723 | 9.99e-08 | 1.70e-06 | 84 |
GO:00448393 | Oral cavity | OSCC | cell cycle G2/M phase transition | 89/7305 | 148/18723 | 1.51e-07 | 2.51e-06 | 89 |
GO:19019914 | Oral cavity | OSCC | negative regulation of mitotic cell cycle phase transition | 104/7305 | 179/18723 | 1.67e-07 | 2.73e-06 | 104 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAOK2 | SNV | Missense_Mutation | | c.340N>T | p.Asp114Tyr | p.D114Y | Q9UL54 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TAOK2 | SNV | Missense_Mutation | novel | c.3578N>T | p.Arg1193Leu | p.R1193L | Q9UL54 | protein_coding | deleterious_low_confidence(0) | benign(0.257) | TCGA-AC-A2QI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
TAOK2 | SNV | Missense_Mutation | rs772517477 | c.1907N>A | p.Arg636His | p.R636H | Q9UL54 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-BH-A0BG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TAOK2 | SNV | Missense_Mutation | | c.671C>T | p.Pro224Leu | p.P224L | Q9UL54 | protein_coding | deleterious(0) | possibly_damaging(0.819) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TAOK2 | SNV | Missense_Mutation | | c.943N>T | p.Ile315Phe | p.I315F | Q9UL54 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-E2-A15L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
TAOK2 | SNV | Missense_Mutation | rs770953476 | c.901G>A | p.Val301Met | p.V301M | Q9UL54 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD |
TAOK2 | insertion | Frame_Shift_Ins | novel | c.1492_1493insCTCACTGTTTCAAATTAGTATGGAT | p.Met498ThrfsTer27 | p.M498Tfs*27 | Q9UL54 | protein_coding | | | TCGA-AO-A03T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
TAOK2 | deletion | Frame_Shift_Del | novel | c.1686delG | p.Lys563SerfsTer32 | p.K563Sfs*32 | Q9UL54 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
TAOK2 | deletion | Frame_Shift_Del | novel | c.2593delG | p.Glu865ArgfsTer31 | p.E865Rfs*31 | Q9UL54 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
TAOK2 | SNV | Missense_Mutation | | c.1465C>T | p.Arg489Trp | p.R489W | Q9UL54 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |