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Gene: TACSTD2 |
Gene summary for TACSTD2 |
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Gene information | Species | Human | Gene symbol | TACSTD2 | Gene ID | 4070 |
Gene name | tumor associated calcium signal transducer 2 | |
Gene Alias | EGP-1 | |
Cytomap | 1p32.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P09758 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4070 | TACSTD2 | GSM4909281 | Human | Breast | IDC | 8.47e-31 | -8.82e-01 | 0.21 |
4070 | TACSTD2 | GSM4909282 | Human | Breast | IDC | 1.32e-21 | 4.71e-01 | -0.0288 |
4070 | TACSTD2 | GSM4909285 | Human | Breast | IDC | 7.61e-09 | 1.01e-01 | 0.21 |
4070 | TACSTD2 | GSM4909286 | Human | Breast | IDC | 1.90e-83 | -1.49e+00 | 0.1081 |
4070 | TACSTD2 | GSM4909288 | Human | Breast | IDC | 2.86e-06 | -7.81e-01 | 0.0988 |
4070 | TACSTD2 | GSM4909290 | Human | Breast | IDC | 2.22e-26 | -8.21e-01 | 0.2096 |
4070 | TACSTD2 | GSM4909291 | Human | Breast | IDC | 1.10e-24 | -1.00e+00 | 0.1753 |
4070 | TACSTD2 | GSM4909292 | Human | Breast | IDC | 3.41e-04 | -9.50e-01 | 0.1236 |
4070 | TACSTD2 | GSM4909293 | Human | Breast | IDC | 1.83e-33 | -7.57e-01 | 0.1581 |
4070 | TACSTD2 | GSM4909294 | Human | Breast | IDC | 1.34e-26 | -8.61e-01 | 0.2022 |
4070 | TACSTD2 | GSM4909296 | Human | Breast | IDC | 2.23e-23 | -7.87e-01 | 0.1524 |
4070 | TACSTD2 | GSM4909297 | Human | Breast | IDC | 3.79e-07 | -5.30e-01 | 0.1517 |
4070 | TACSTD2 | GSM4909298 | Human | Breast | IDC | 4.47e-27 | -6.79e-01 | 0.1551 |
4070 | TACSTD2 | GSM4909300 | Human | Breast | IDC | 2.04e-02 | 3.32e-01 | 0.0334 |
4070 | TACSTD2 | GSM4909301 | Human | Breast | IDC | 7.48e-20 | -6.41e-01 | 0.1577 |
4070 | TACSTD2 | GSM4909302 | Human | Breast | IDC | 9.22e-18 | -6.63e-01 | 0.1545 |
4070 | TACSTD2 | GSM4909304 | Human | Breast | IDC | 5.32e-47 | -1.01e+00 | 0.1636 |
4070 | TACSTD2 | GSM4909305 | Human | Breast | IDC | 7.21e-04 | 1.61e-01 | 0.0436 |
4070 | TACSTD2 | GSM4909306 | Human | Breast | IDC | 2.82e-11 | -3.19e-01 | 0.1564 |
4070 | TACSTD2 | GSM4909307 | Human | Breast | IDC | 1.86e-18 | -7.36e-01 | 0.1569 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007208011 | Breast | IDC | nephron tubule development | 15/1434 | 91/18723 | 3.70e-03 | 3.04e-02 | 15 |
GO:006068811 | Breast | IDC | regulation of morphogenesis of a branching structure | 10/1434 | 50/18723 | 4.09e-03 | 3.25e-02 | 10 |
GO:00721631 | Breast | IDC | mesonephric epithelium development | 15/1434 | 92/18723 | 4.12e-03 | 3.26e-02 | 15 |
GO:00721641 | Breast | IDC | mesonephric tubule development | 15/1434 | 92/18723 | 4.12e-03 | 3.26e-02 | 15 |
GO:0060993 | Breast | IDC | kidney morphogenesis | 15/1434 | 93/18723 | 4.57e-03 | 3.52e-02 | 15 |
GO:0072028 | Breast | IDC | nephron morphogenesis | 13/1434 | 76/18723 | 4.81e-03 | 3.67e-02 | 13 |
GO:00613262 | Breast | IDC | renal tubule development | 15/1434 | 94/18723 | 5.06e-03 | 3.79e-02 | 15 |
GO:00108109 | Breast | IDC | regulation of cell-substrate adhesion | 28/1434 | 221/18723 | 5.88e-03 | 4.24e-02 | 28 |
GO:00018231 | Breast | IDC | mesonephros development | 15/1434 | 96/18723 | 6.17e-03 | 4.40e-02 | 15 |
GO:00016555 | Breast | IDC | urogenital system development | 39/1434 | 338/18723 | 6.75e-03 | 4.68e-02 | 39 |
GO:00720781 | Breast | IDC | nephron tubule morphogenesis | 12/1434 | 71/18723 | 7.29e-03 | 4.96e-02 | 12 |
GO:003297024 | Breast | DCIS | regulation of actin filament-based process | 56/1390 | 397/18723 | 2.50e-06 | 8.74e-05 | 56 |
GO:190290324 | Breast | DCIS | regulation of supramolecular fiber organization | 54/1390 | 383/18723 | 3.82e-06 | 1.16e-04 | 54 |
GO:001063121 | Breast | DCIS | epithelial cell migration | 51/1390 | 357/18723 | 4.83e-06 | 1.43e-04 | 51 |
GO:009013221 | Breast | DCIS | epithelium migration | 51/1390 | 360/18723 | 6.14e-06 | 1.75e-04 | 51 |
GO:009013021 | Breast | DCIS | tissue migration | 51/1390 | 365/18723 | 9.09e-06 | 2.45e-04 | 51 |
GO:000166723 | Breast | DCIS | ameboidal-type cell migration | 62/1390 | 475/18723 | 9.60e-06 | 2.56e-04 | 62 |
GO:001063221 | Breast | DCIS | regulation of epithelial cell migration | 43/1390 | 292/18723 | 1.23e-05 | 3.13e-04 | 43 |
GO:003295624 | Breast | DCIS | regulation of actin cytoskeleton organization | 48/1390 | 358/18723 | 4.82e-05 | 9.92e-04 | 48 |
GO:000701524 | Breast | DCIS | actin filament organization | 56/1390 | 442/18723 | 5.90e-05 | 1.19e-03 | 56 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TACSTD2 | deletion | Frame_Shift_Del | novel | c.534delG | p.Leu179SerfsTer92 | p.L179Sfs*92 | P09758 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TACSTD2 | SNV | Missense_Mutation | novel | c.476N>A | p.Arg159His | p.R159H | P09758 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACSTD2 | SNV | Missense_Mutation | novel | c.884T>C | p.Leu295Pro | p.L295P | P09758 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
TACSTD2 | SNV | Missense_Mutation | c.763C>T | p.Arg255Cys | p.R255C | P09758 | protein_coding | deleterious(0) | benign(0.353) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TACSTD2 | SNV | Missense_Mutation | novel | c.745G>A | p.Glu249Lys | p.E249K | P09758 | protein_coding | tolerated(0.12) | benign(0.01) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
TACSTD2 | SNV | Missense_Mutation | novel | c.821C>T | p.Thr274Ile | p.T274I | P09758 | protein_coding | tolerated(0.09) | benign(0.373) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACSTD2 | SNV | Missense_Mutation | novel | c.334G>A | p.Gly112Ser | p.G112S | P09758 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACSTD2 | SNV | Missense_Mutation | novel | c.578N>T | p.Ala193Val | p.A193V | P09758 | protein_coding | tolerated(0.08) | possibly_damaging(0.769) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACSTD2 | SNV | Missense_Mutation | novel | c.908N>T | p.Ser303Leu | p.S303L | P09758 | protein_coding | tolerated(0.1) | benign(0.001) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACSTD2 | SNV | Missense_Mutation | novel | c.866N>C | p.Val289Ala | p.V289A | P09758 | protein_coding | tolerated(0.73) | benign(0.056) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4070 | TACSTD2 | NA | antibody | 249565933 | ||
4070 | TACSTD2 | NA | N/A |
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