Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SUZ12_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SUZ12_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SUZ12_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SUZ12_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SUZ12_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000821322 | Oral cavity | NEOLP | protein alkylation | 37/2005 | 181/18723 | 8.15e-05 | 1.02e-03 | 37 |
GO:001820531 | Oral cavity | NEOLP | peptidyl-lysine modification | 64/2005 | 376/18723 | 1.21e-04 | 1.43e-03 | 64 |
GO:001657122 | Oral cavity | NEOLP | histone methylation | 30/2005 | 141/18723 | 1.77e-04 | 1.95e-03 | 30 |
GO:003496822 | Oral cavity | NEOLP | histone lysine methylation | 25/2005 | 115/18723 | 4.21e-04 | 3.89e-03 | 25 |
GO:00182122 | Oral cavity | NEOLP | peptidyl-tyrosine modification | 62/2005 | 378/18723 | 4.27e-04 | 3.91e-03 | 62 |
GO:00181082 | Oral cavity | NEOLP | peptidyl-tyrosine phosphorylation | 61/2005 | 375/18723 | 5.88e-04 | 5.08e-03 | 61 |
GO:005067822 | Oral cavity | NEOLP | regulation of epithelial cell proliferation | 59/2005 | 381/18723 | 2.36e-03 | 1.51e-02 | 59 |
GO:001802213 | Oral cavity | NEOLP | peptidyl-lysine methylation | 25/2005 | 131/18723 | 2.95e-03 | 1.81e-02 | 25 |
GO:00507302 | Oral cavity | NEOLP | regulation of peptidyl-tyrosine phosphorylation | 41/2005 | 264/18723 | 9.51e-03 | 4.50e-02 | 41 |
GO:005067319 | Skin | AK | epithelial cell proliferation | 86/1910 | 437/18723 | 1.52e-09 | 1.43e-07 | 86 |
GO:00165709 | Skin | AK | histone modification | 84/1910 | 463/18723 | 1.10e-07 | 4.95e-06 | 84 |
GO:005067818 | Skin | AK | regulation of epithelial cell proliferation | 72/1910 | 381/18723 | 1.76e-07 | 7.28e-06 | 72 |
GO:00182058 | Skin | AK | peptidyl-lysine modification | 66/1910 | 376/18723 | 7.80e-06 | 1.72e-04 | 66 |
GO:00064799 | Skin | AK | protein methylation | 38/1910 | 181/18723 | 1.21e-05 | 2.46e-04 | 38 |
GO:00082139 | Skin | AK | protein alkylation | 38/1910 | 181/18723 | 1.21e-05 | 2.46e-04 | 38 |
GO:00349689 | Skin | AK | histone lysine methylation | 27/1910 | 115/18723 | 2.75e-05 | 4.81e-04 | 27 |
GO:00165719 | Skin | AK | histone methylation | 31/1910 | 141/18723 | 2.92e-05 | 5.02e-04 | 31 |
GO:004593627 | Skin | AK | negative regulation of phosphate metabolic process | 69/1910 | 441/18723 | 2.08e-04 | 2.34e-03 | 69 |
GO:001056327 | Skin | AK | negative regulation of phosphorus metabolic process | 69/1910 | 442/18723 | 2.22e-04 | 2.47e-03 | 69 |
GO:00180228 | Skin | AK | peptidyl-lysine methylation | 27/1910 | 131/18723 | 2.87e-04 | 3.00e-03 | 27 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SUZ12 | SNV | Missense_Mutation | | c.1147N>A | p.Glu383Lys | p.E383K | Q15022 | protein_coding | tolerated(0.18) | benign(0.027) | TCGA-A2-A0YH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
SUZ12 | SNV | Missense_Mutation | | c.285N>C | p.Gln95His | p.Q95H | Q15022 | protein_coding | deleterious(0) | possibly_damaging(0.671) | TCGA-A2-A0YJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
SUZ12 | SNV | Missense_Mutation | novel | c.432N>C | p.Met144Ile | p.M144I | Q15022 | protein_coding | deleterious(0.02) | benign(0.023) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
SUZ12 | SNV | Missense_Mutation | novel | c.907N>C | p.Asp303His | p.D303H | Q15022 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AC-A5XU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
SUZ12 | SNV | Missense_Mutation | | c.955N>C | p.Met319Leu | p.M319L | Q15022 | protein_coding | tolerated(0.71) | benign(0.007) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SUZ12 | SNV | Missense_Mutation | | c.1585C>G | p.Leu529Val | p.L529V | Q15022 | protein_coding | tolerated(0.08) | probably_damaging(0.967) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
SUZ12 | SNV | Missense_Mutation | novel | c.776G>A | p.Arg259Lys | p.R259K | Q15022 | protein_coding | tolerated(0.68) | benign(0.003) | TCGA-E2-A2P6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
SUZ12 | SNV | Missense_Mutation | novel | c.110N>T | p.Ser37Leu | p.S37L | Q15022 | protein_coding | deleterious_low_confidence(0.03) | benign(0.01) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
SUZ12 | SNV | Missense_Mutation | | c.1412N>G | p.His471Arg | p.H471R | Q15022 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
SUZ12 | SNV | Missense_Mutation | novel | c.367N>C | p.Ser123Pro | p.S123P | Q15022 | protein_coding | deleterious(0.03) | possibly_damaging(0.77) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |