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Gene: STK38 |
Gene summary for STK38 |
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Gene information | Species | Human | Gene symbol | STK38 | Gene ID | 11329 |
Gene name | serine/threonine kinase 38 | |
Gene Alias | NDR | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024RD18 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11329 | STK38 | CCI_1 | Human | Cervix | CC | 1.16e-09 | 1.11e+00 | 0.528 |
11329 | STK38 | CCI_2 | Human | Cervix | CC | 1.06e-08 | 1.15e+00 | 0.5249 |
11329 | STK38 | CCI_3 | Human | Cervix | CC | 2.50e-12 | 9.14e-01 | 0.516 |
11329 | STK38 | sample3 | Human | Cervix | CC | 8.28e-05 | 2.34e-01 | 0.1387 |
11329 | STK38 | T3 | Human | Cervix | CC | 1.95e-03 | 2.27e-01 | 0.1389 |
11329 | STK38 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.36e-07 | 6.29e-01 | -0.0811 |
11329 | STK38 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.72e-02 | 5.00e-01 | -0.1088 |
11329 | STK38 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.69e-22 | 8.64e-01 | -0.1954 |
11329 | STK38 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.03e-03 | 5.62e-01 | -0.1526 |
11329 | STK38 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.25e-07 | 5.47e-01 | -0.1001 |
11329 | STK38 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.78e-09 | 8.04e-01 | -0.059 |
11329 | STK38 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.56e-04 | 5.79e-01 | -0.0842 |
11329 | STK38 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.66e-03 | 6.05e-01 | -0.0177 |
11329 | STK38 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.22e-03 | 4.92e-01 | 0.0338 |
11329 | STK38 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 6.43e-10 | 8.07e-01 | 0.281 |
11329 | STK38 | F007 | Human | Colorectum | FAP | 1.38e-05 | 3.34e-01 | 0.1176 |
11329 | STK38 | A002-C-010 | Human | Colorectum | FAP | 1.40e-05 | 2.07e-01 | 0.242 |
11329 | STK38 | A001-C-207 | Human | Colorectum | FAP | 1.00e-04 | 9.61e-02 | 0.1278 |
11329 | STK38 | A015-C-203 | Human | Colorectum | FAP | 1.57e-47 | 4.42e-01 | -0.1294 |
11329 | STK38 | A015-C-204 | Human | Colorectum | FAP | 8.76e-08 | 9.41e-02 | -0.0228 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434051 | Colorectum | CRC | regulation of MAP kinase activity | 34/2078 | 177/18723 | 9.84e-04 | 1.18e-02 | 34 |
GO:00064694 | Colorectum | CRC | negative regulation of protein kinase activity | 39/2078 | 212/18723 | 1.04e-03 | 1.22e-02 | 39 |
GO:00019335 | Colorectum | CRC | negative regulation of protein phosphorylation | 55/2078 | 342/18723 | 3.05e-03 | 2.72e-02 | 55 |
GO:00459365 | Colorectum | CRC | negative regulation of phosphate metabolic process | 68/2078 | 441/18723 | 3.15e-03 | 2.78e-02 | 68 |
GO:00105635 | Colorectum | CRC | negative regulation of phosphorus metabolic process | 68/2078 | 442/18723 | 3.33e-03 | 2.85e-02 | 68 |
GO:00336734 | Colorectum | CRC | negative regulation of kinase activity | 40/2078 | 237/18723 | 4.58e-03 | 3.57e-02 | 40 |
GO:00423265 | Colorectum | CRC | negative regulation of phosphorylation | 59/2078 | 385/18723 | 6.45e-03 | 4.67e-02 | 59 |
GO:004593626 | Esophagus | HGIN | negative regulation of phosphate metabolic process | 89/2587 | 441/18723 | 1.24e-04 | 2.54e-03 | 89 |
GO:001056326 | Esophagus | HGIN | negative regulation of phosphorus metabolic process | 89/2587 | 442/18723 | 1.34e-04 | 2.71e-03 | 89 |
GO:004232620 | Esophagus | HGIN | negative regulation of phosphorylation | 78/2587 | 385/18723 | 2.77e-04 | 4.77e-03 | 78 |
GO:000193320 | Esophagus | HGIN | negative regulation of protein phosphorylation | 69/2587 | 342/18723 | 6.81e-04 | 9.26e-03 | 69 |
GO:005134827 | Esophagus | HGIN | negative regulation of transferase activity | 55/2587 | 268/18723 | 1.51e-03 | 1.74e-02 | 55 |
GO:004340919 | Esophagus | HGIN | negative regulation of MAPK cascade | 38/2587 | 180/18723 | 4.58e-03 | 3.96e-02 | 38 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:0051348111 | Esophagus | ESCC | negative regulation of transferase activity | 177/8552 | 268/18723 | 1.08e-11 | 4.00e-10 | 177 |
GO:007190016 | Esophagus | ESCC | regulation of protein serine/threonine kinase activity | 227/8552 | 359/18723 | 1.12e-11 | 4.10e-10 | 227 |
GO:0042326111 | Esophagus | ESCC | negative regulation of phosphorylation | 237/8552 | 385/18723 | 1.86e-10 | 5.33e-09 | 237 |
GO:0001933111 | Esophagus | ESCC | negative regulation of protein phosphorylation | 213/8552 | 342/18723 | 3.54e-10 | 9.76e-09 | 213 |
GO:003367319 | Esophagus | ESCC | negative regulation of kinase activity | 154/8552 | 237/18723 | 1.38e-09 | 3.27e-08 | 154 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK38 | SNV | Missense_Mutation | novel | c.160N>A | p.Glu54Lys | p.E54K | Q15208 | protein_coding | tolerated(0.16) | benign(0.005) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
STK38 | SNV | Missense_Mutation | novel | c.1255N>G | p.Leu419Val | p.L419V | Q15208 | protein_coding | tolerated(0.3) | benign(0.158) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STK38 | SNV | Missense_Mutation | novel | c.379N>C | p.Glu127Gln | p.E127Q | Q15208 | protein_coding | tolerated(0.16) | benign(0.362) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
STK38 | SNV | Missense_Mutation | c.601G>T | p.Asp201Tyr | p.D201Y | Q15208 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
STK38 | SNV | Missense_Mutation | c.639N>G | p.Ile213Met | p.I213M | Q15208 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-EK-A2RK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
STK38 | SNV | Missense_Mutation | c.766N>A | p.Asp256Asn | p.D256N | Q15208 | protein_coding | tolerated(0.23) | probably_damaging(0.969) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
STK38 | SNV | Missense_Mutation | c.1069A>G | p.Ile357Val | p.I357V | Q15208 | protein_coding | tolerated(0.09) | benign(0.192) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
STK38 | SNV | Missense_Mutation | c.813N>C | p.Trp271Cys | p.W271C | Q15208 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STK38 | SNV | Missense_Mutation | c.562N>A | p.Glu188Lys | p.E188K | Q15208 | protein_coding | tolerated(0.86) | benign(0.01) | TCGA-CK-4950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folfox | SD | |
STK38 | SNV | Missense_Mutation | c.457T>C | p.Phe153Leu | p.F153L | Q15208 | protein_coding | deleterious(0.01) | possibly_damaging(0.803) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11329 | STK38 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 249565889 |
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