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Gene: SOSTDC1 |
Gene summary for SOSTDC1 |
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Gene information | Species | Human | Gene symbol | SOSTDC1 | Gene ID | 25928 |
Gene name | sclerostin domain containing 1 | |
Gene Alias | CDA019 | |
Cytomap | 7p21.2 | |
Gene Type | protein-coding | GO ID | GO:0001942 | UniProtAcc | A4D125 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25928 | SOSTDC1 | P2T-E | Human | Esophagus | ESCC | 2.91e-23 | 6.07e-01 | 0.1177 |
25928 | SOSTDC1 | P10T-E | Human | Esophagus | ESCC | 1.37e-105 | 2.64e+00 | 0.116 |
25928 | SOSTDC1 | P12T-E | Human | Esophagus | ESCC | 1.57e-22 | 7.05e-01 | 0.1122 |
25928 | SOSTDC1 | P15T-E | Human | Esophagus | ESCC | 1.70e-20 | 1.26e+00 | 0.1149 |
25928 | SOSTDC1 | P16T-E | Human | Esophagus | ESCC | 7.46e-103 | 3.15e+00 | 0.1153 |
25928 | SOSTDC1 | P20T-E | Human | Esophagus | ESCC | 8.03e-21 | 1.04e+00 | 0.1124 |
25928 | SOSTDC1 | P22T-E | Human | Esophagus | ESCC | 1.68e-31 | 1.08e+00 | 0.1236 |
25928 | SOSTDC1 | P26T-E | Human | Esophagus | ESCC | 9.11e-18 | 3.58e-01 | 0.1276 |
25928 | SOSTDC1 | P27T-E | Human | Esophagus | ESCC | 6.35e-08 | 4.28e-01 | 0.1055 |
25928 | SOSTDC1 | P30T-E | Human | Esophagus | ESCC | 3.93e-30 | 1.79e+00 | 0.137 |
25928 | SOSTDC1 | P31T-E | Human | Esophagus | ESCC | 1.35e-113 | 4.31e+00 | 0.1251 |
25928 | SOSTDC1 | P32T-E | Human | Esophagus | ESCC | 2.55e-05 | 3.97e-01 | 0.1666 |
25928 | SOSTDC1 | P36T-E | Human | Esophagus | ESCC | 1.77e-04 | 5.37e-01 | 0.1187 |
25928 | SOSTDC1 | P37T-E | Human | Esophagus | ESCC | 9.63e-20 | 6.42e-01 | 0.1371 |
25928 | SOSTDC1 | P49T-E | Human | Esophagus | ESCC | 4.18e-05 | 9.26e-01 | 0.1768 |
25928 | SOSTDC1 | P56T-E | Human | Esophagus | ESCC | 3.95e-15 | 3.57e+00 | 0.1613 |
25928 | SOSTDC1 | P57T-E | Human | Esophagus | ESCC | 2.18e-02 | 1.73e-01 | 0.0926 |
25928 | SOSTDC1 | P61T-E | Human | Esophagus | ESCC | 2.26e-13 | 5.41e-01 | 0.099 |
25928 | SOSTDC1 | P62T-E | Human | Esophagus | ESCC | 4.80e-28 | 1.37e+00 | 0.1302 |
25928 | SOSTDC1 | P74T-E | Human | Esophagus | ESCC | 1.79e-08 | 3.44e-01 | 0.1479 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00019422 | Skin | cSCC | hair follicle development | 36/4864 | 81/18723 | 2.40e-04 | 1.96e-03 | 36 |
GO:004230321 | Skin | cSCC | molting cycle | 44/4864 | 107/18723 | 4.41e-04 | 3.39e-03 | 44 |
GO:004263321 | Skin | cSCC | hair cycle | 44/4864 | 107/18723 | 4.41e-04 | 3.39e-03 | 44 |
GO:002240421 | Skin | cSCC | molting cycle process | 36/4864 | 84/18723 | 5.64e-04 | 4.12e-03 | 36 |
GO:002240521 | Skin | cSCC | hair cycle process | 36/4864 | 84/18723 | 5.64e-04 | 4.12e-03 | 36 |
GO:006007024 | Skin | cSCC | canonical Wnt signaling pathway | 104/4864 | 303/18723 | 7.13e-04 | 5.03e-03 | 104 |
GO:003087922 | Skin | cSCC | mammary gland development | 53/4864 | 137/18723 | 7.21e-04 | 5.05e-03 | 53 |
GO:004544513 | Skin | cSCC | myoblast differentiation | 35/4864 | 84/18723 | 1.23e-03 | 7.97e-03 | 35 |
GO:006118012 | Skin | cSCC | mammary gland epithelium development | 29/4864 | 67/18723 | 1.55e-03 | 9.60e-03 | 29 |
GO:006082824 | Skin | cSCC | regulation of canonical Wnt signaling pathway | 87/4864 | 253/18723 | 1.74e-03 | 1.06e-02 | 87 |
GO:002261221 | Skin | cSCC | gland morphogenesis | 45/4864 | 118/18723 | 2.43e-03 | 1.39e-02 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOSTDC1 | SNV | Missense_Mutation | novel | c.399N>G | p.Cys133Trp | p.C133W | Q6X4U4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1FH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SOSTDC1 | insertion | Frame_Shift_Ins | novel | c.116_117insAG | p.Pro41PhefsTer11 | p.P41Ffs*11 | Q6X4U4 | protein_coding | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | ||
SOSTDC1 | insertion | Nonsense_Mutation | novel | c.115_116insTGTACAAGTAAAACACACTTACTGTTCCGATCCAGTC | p.Pro39LeufsTer4 | p.P39Lfs*4 | Q6X4U4 | protein_coding | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | ||
SOSTDC1 | SNV | Missense_Mutation | rs770948074 | c.458N>A | p.Arg153His | p.R153H | Q6X4U4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SOSTDC1 | SNV | Missense_Mutation | rs367980297 | c.416G>A | p.Arg139His | p.R139H | Q6X4U4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SOSTDC1 | SNV | Missense_Mutation | rs770948074 | c.458G>A | p.Arg153His | p.R153H | Q6X4U4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOSTDC1 | SNV | Missense_Mutation | rs367980297 | c.416G>A | p.Arg139His | p.R139H | Q6X4U4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D1-A16Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOSTDC1 | SNV | Missense_Mutation | novel | c.59N>A | p.Ser20Asn | p.S20N | Q6X4U4 | protein_coding | tolerated(0.16) | benign(0.229) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
SOSTDC1 | SNV | Missense_Mutation | novel | c.406N>T | p.Asp136Tyr | p.D136Y | Q6X4U4 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
SOSTDC1 | SNV | Missense_Mutation | novel | c.193N>A | p.Leu65Met | p.L65M | Q6X4U4 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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