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Gene: SDAD1 |
Gene summary for SDAD1 |
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Gene information | Species | Human | Gene symbol | SDAD1 | Gene ID | 55153 |
Gene name | SDA1 domain containing 1 | |
Gene Alias | SDAD1 | |
Cytomap | 4q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000054 | UniProtAcc | B4DT66 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55153 | SDAD1 | LZE4T | Human | Esophagus | ESCC | 2.05e-07 | 3.42e-01 | 0.0811 |
55153 | SDAD1 | LZE7T | Human | Esophagus | ESCC | 5.64e-05 | 6.60e-01 | 0.0667 |
55153 | SDAD1 | LZE20T | Human | Esophagus | ESCC | 4.17e-06 | 1.92e-01 | 0.0662 |
55153 | SDAD1 | LZE22T | Human | Esophagus | ESCC | 1.27e-04 | 3.76e-01 | 0.068 |
55153 | SDAD1 | LZE24T | Human | Esophagus | ESCC | 5.09e-17 | 4.77e-01 | 0.0596 |
55153 | SDAD1 | LZE6T | Human | Esophagus | ESCC | 3.47e-03 | 3.48e-01 | 0.0845 |
55153 | SDAD1 | P1T-E | Human | Esophagus | ESCC | 2.09e-02 | 2.75e-01 | 0.0875 |
55153 | SDAD1 | P2T-E | Human | Esophagus | ESCC | 1.08e-49 | 9.09e-01 | 0.1177 |
55153 | SDAD1 | P4T-E | Human | Esophagus | ESCC | 1.45e-20 | 7.00e-01 | 0.1323 |
55153 | SDAD1 | P5T-E | Human | Esophagus | ESCC | 4.44e-14 | 3.08e-01 | 0.1327 |
55153 | SDAD1 | P8T-E | Human | Esophagus | ESCC | 2.35e-30 | 4.30e-01 | 0.0889 |
55153 | SDAD1 | P9T-E | Human | Esophagus | ESCC | 1.55e-11 | 3.57e-01 | 0.1131 |
55153 | SDAD1 | P10T-E | Human | Esophagus | ESCC | 1.03e-26 | 5.83e-01 | 0.116 |
55153 | SDAD1 | P11T-E | Human | Esophagus | ESCC | 1.63e-16 | 6.88e-01 | 0.1426 |
55153 | SDAD1 | P12T-E | Human | Esophagus | ESCC | 2.42e-22 | 5.53e-01 | 0.1122 |
55153 | SDAD1 | P15T-E | Human | Esophagus | ESCC | 1.06e-29 | 6.36e-01 | 0.1149 |
55153 | SDAD1 | P16T-E | Human | Esophagus | ESCC | 1.71e-46 | 9.92e-01 | 0.1153 |
55153 | SDAD1 | P17T-E | Human | Esophagus | ESCC | 1.15e-07 | 5.67e-01 | 0.1278 |
55153 | SDAD1 | P19T-E | Human | Esophagus | ESCC | 2.38e-08 | 6.78e-01 | 0.1662 |
55153 | SDAD1 | P20T-E | Human | Esophagus | ESCC | 1.47e-17 | 4.28e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315037 | Thyroid | PTC | protein-containing complex localization | 107/5968 | 220/18723 | 1.47e-07 | 2.82e-06 | 107 |
GO:00714267 | Thyroid | PTC | ribonucleoprotein complex export from nucleus | 46/5968 | 76/18723 | 2.48e-07 | 4.32e-06 | 46 |
GO:00000549 | Thyroid | PTC | ribosomal subunit export from nucleus | 10/5968 | 14/18723 | 2.77e-03 | 1.38e-02 | 10 |
GO:00337509 | Thyroid | PTC | ribosome localization | 10/5968 | 14/18723 | 2.77e-03 | 1.38e-02 | 10 |
GO:00714286 | Thyroid | PTC | rRNA-containing ribonucleoprotein complex export from nucleus | 10/5968 | 15/18723 | 5.94e-03 | 2.64e-02 | 10 |
GO:002261334 | Thyroid | ATC | ribonucleoprotein complex biogenesis | 292/6293 | 463/18723 | 3.05e-39 | 9.63e-36 | 292 |
GO:004225434 | Thyroid | ATC | ribosome biogenesis | 203/6293 | 299/18723 | 3.63e-34 | 4.59e-31 | 203 |
GO:000691326 | Thyroid | ATC | nucleocytoplasmic transport | 180/6293 | 301/18723 | 6.97e-21 | 1.30e-18 | 180 |
GO:005116926 | Thyroid | ATC | nuclear transport | 180/6293 | 301/18723 | 6.97e-21 | 1.30e-18 | 180 |
GO:005116833 | Thyroid | ATC | nuclear export | 100/6293 | 154/18723 | 1.63e-15 | 1.20e-13 | 100 |
GO:004227335 | Thyroid | ATC | ribosomal large subunit biogenesis | 57/6293 | 72/18723 | 2.56e-15 | 1.82e-13 | 57 |
GO:005165625 | Thyroid | ATC | establishment of organelle localization | 206/6293 | 390/18723 | 2.62e-15 | 1.84e-13 | 206 |
GO:007116614 | Thyroid | ATC | ribonucleoprotein complex localization | 47/6293 | 77/18723 | 7.43e-07 | 9.89e-06 | 47 |
GO:003150316 | Thyroid | ATC | protein-containing complex localization | 108/6293 | 220/18723 | 1.33e-06 | 1.69e-05 | 108 |
GO:007142614 | Thyroid | ATC | ribonucleoprotein complex export from nucleus | 46/6293 | 76/18723 | 1.37e-06 | 1.71e-05 | 46 |
GO:000005413 | Thyroid | ATC | ribosomal subunit export from nucleus | 10/6293 | 14/18723 | 4.31e-03 | 1.80e-02 | 10 |
GO:003375013 | Thyroid | ATC | ribosome localization | 10/6293 | 14/18723 | 4.31e-03 | 1.80e-02 | 10 |
GO:007142812 | Thyroid | ATC | rRNA-containing ribonucleoprotein complex export from nucleus | 10/6293 | 15/18723 | 9.05e-03 | 3.39e-02 | 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SDAD1 | SNV | Missense_Mutation | c.1005N>G | p.Phe335Leu | p.F335L | Q9NVU7 | protein_coding | tolerated(0.05) | benign(0.242) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
SDAD1 | insertion | Frame_Shift_Ins | novel | c.1397_1398insGGGCTTCC | p.Tyr467GlyfsTer7 | p.Y467Gfs*7 | Q9NVU7 | protein_coding | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
SDAD1 | deletion | Frame_Shift_Del | c.1716delN | p.Lys574AsnfsTer10 | p.K574Nfs*10 | Q9NVU7 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
SDAD1 | SNV | Missense_Mutation | rs773176883 | c.526G>A | p.Ala176Thr | p.A176T | Q9NVU7 | protein_coding | tolerated(0.08) | benign(0.207) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SDAD1 | SNV | Missense_Mutation | c.55N>G | p.Leu19Val | p.L19V | Q9NVU7 | protein_coding | deleterious(0.02) | benign(0.266) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SDAD1 | SNV | Missense_Mutation | c.388G>A | p.Asp130Asn | p.D130N | Q9NVU7 | protein_coding | deleterious(0.03) | probably_damaging(0.973) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SDAD1 | SNV | Missense_Mutation | rs557777418 | c.1871G>A | p.Arg624Gln | p.R624Q | Q9NVU7 | protein_coding | deleterious(0) | benign(0.385) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
SDAD1 | SNV | Missense_Mutation | c.438G>T | p.Lys146Asn | p.K146N | Q9NVU7 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SDAD1 | SNV | Missense_Mutation | c.1935N>T | p.Lys645Asn | p.K645N | Q9NVU7 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SDAD1 | SNV | Missense_Mutation | c.1336N>G | p.Met446Val | p.M446V | Q9NVU7 | protein_coding | deleterious(0.01) | benign(0.338) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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