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Gene: RPP25 |
Gene summary for RPP25 |
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Gene information | Species | Human | Gene symbol | RPP25 | Gene ID | 54913 |
Gene name | ribonuclease P and MRP subunit p25 | |
Gene Alias | RPP25 | |
Cytomap | 15q24.2 | |
Gene Type | protein-coding | GO ID | GO:0000966 | UniProtAcc | Q9BUL9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54913 | RPP25 | LZE4T | Human | Esophagus | ESCC | 2.41e-05 | 2.01e-01 | 0.0811 |
54913 | RPP25 | LZE20T | Human | Esophagus | ESCC | 1.68e-02 | 7.81e-02 | 0.0662 |
54913 | RPP25 | LZE22T | Human | Esophagus | ESCC | 6.53e-05 | 3.99e-01 | 0.068 |
54913 | RPP25 | LZE24T | Human | Esophagus | ESCC | 1.64e-09 | 2.50e-01 | 0.0596 |
54913 | RPP25 | P1T-E | Human | Esophagus | ESCC | 1.40e-10 | 6.96e-01 | 0.0875 |
54913 | RPP25 | P4T-E | Human | Esophagus | ESCC | 1.53e-16 | 2.93e-01 | 0.1323 |
54913 | RPP25 | P5T-E | Human | Esophagus | ESCC | 1.08e-13 | 3.01e-01 | 0.1327 |
54913 | RPP25 | P8T-E | Human | Esophagus | ESCC | 6.26e-05 | 1.05e-01 | 0.0889 |
54913 | RPP25 | P9T-E | Human | Esophagus | ESCC | 7.71e-19 | 3.26e-01 | 0.1131 |
54913 | RPP25 | P10T-E | Human | Esophagus | ESCC | 7.83e-28 | 4.97e-01 | 0.116 |
54913 | RPP25 | P11T-E | Human | Esophagus | ESCC | 4.42e-05 | 2.67e-01 | 0.1426 |
54913 | RPP25 | P15T-E | Human | Esophagus | ESCC | 1.14e-46 | 9.16e-01 | 0.1149 |
54913 | RPP25 | P17T-E | Human | Esophagus | ESCC | 6.47e-04 | 1.33e-01 | 0.1278 |
54913 | RPP25 | P19T-E | Human | Esophagus | ESCC | 4.17e-05 | 5.31e-01 | 0.1662 |
54913 | RPP25 | P20T-E | Human | Esophagus | ESCC | 1.85e-19 | 4.42e-01 | 0.1124 |
54913 | RPP25 | P21T-E | Human | Esophagus | ESCC | 2.63e-17 | 4.08e-01 | 0.1617 |
54913 | RPP25 | P22T-E | Human | Esophagus | ESCC | 1.12e-12 | 1.77e-01 | 0.1236 |
54913 | RPP25 | P23T-E | Human | Esophagus | ESCC | 9.67e-46 | 1.44e+00 | 0.108 |
54913 | RPP25 | P24T-E | Human | Esophagus | ESCC | 1.47e-12 | 3.59e-01 | 0.1287 |
54913 | RPP25 | P26T-E | Human | Esophagus | ESCC | 9.13e-42 | 7.78e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00016821 | Oral cavity | LP | tRNA 5'-leader removal | 8/4623 | 13/18723 | 5.19e-03 | 3.19e-02 | 8 |
GO:00905021 | Oral cavity | LP | RNA phosphodiester bond hydrolysis, endonucleolytic | 31/4623 | 82/18723 | 5.66e-03 | 3.41e-02 | 31 |
GO:00080331 | Oral cavity | LP | tRNA processing | 44/4623 | 127/18723 | 7.50e-03 | 4.15e-02 | 44 |
GO:003447017 | Skin | cSCC | ncRNA processing | 215/4864 | 395/18723 | 6.83e-34 | 4.28e-31 | 215 |
GO:003466013 | Skin | cSCC | ncRNA metabolic process | 234/4864 | 485/18723 | 1.37e-26 | 4.77e-24 | 234 |
GO:00991164 | Skin | cSCC | tRNA 5'-end processing | 11/4864 | 16/18723 | 4.08e-04 | 3.18e-03 | 11 |
GO:00009664 | Skin | cSCC | RNA 5'-end processing | 14/4864 | 23/18723 | 4.32e-04 | 3.34e-03 | 14 |
GO:00344714 | Skin | cSCC | ncRNA 5'-end processing | 13/4864 | 21/18723 | 5.53e-04 | 4.05e-03 | 13 |
GO:00080334 | Skin | cSCC | tRNA processing | 49/4864 | 127/18723 | 1.20e-03 | 7.81e-03 | 49 |
GO:00016824 | Skin | cSCC | tRNA 5'-leader removal | 9/4864 | 13/18723 | 1.33e-03 | 8.50e-03 | 9 |
GO:00063993 | Skin | cSCC | tRNA metabolic process | 64/4864 | 179/18723 | 2.34e-03 | 1.36e-02 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPP25 | SNV | Missense_Mutation | novel | c.382N>C | p.Val128Leu | p.V128L | Q9BUL9 | protein_coding | deleterious(0.04) | probably_damaging(0.976) | TCGA-C5-A7XC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RPP25 | SNV | Missense_Mutation | novel | c.497C>T | p.Ala166Val | p.A166V | Q9BUL9 | protein_coding | tolerated(0.16) | benign(0) | TCGA-VS-A9U7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RPP25 | deletion | Frame_Shift_Del | c.329delN | p.Pro110ArgfsTer64 | p.P110Rfs*64 | Q9BUL9 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
RPP25 | insertion | Frame_Shift_Ins | novel | c.124_131dupGAAGGCAG | p.Ser44ArgfsTer9 | p.S44Rfs*9 | Q9BUL9 | protein_coding | TCGA-AH-6897-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
RPP25 | SNV | Missense_Mutation | novel | c.548C>T | p.Ala183Val | p.A183V | Q9BUL9 | protein_coding | deleterious(0.04) | benign(0.072) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
RPP25 | SNV | Missense_Mutation | novel | c.548C>T | p.Ala183Val | p.A183V | Q9BUL9 | protein_coding | deleterious(0.04) | benign(0.072) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
RPP25 | SNV | Missense_Mutation | novel | c.496N>A | p.Ala166Thr | p.A166T | Q9BUL9 | protein_coding | tolerated(0.62) | benign(0) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPP25 | SNV | Missense_Mutation | c.526C>A | p.Pro176Thr | p.P176T | Q9BUL9 | protein_coding | tolerated(0.08) | benign(0) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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