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Gene: RPL7 |
Gene summary for RPL7 |
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Gene information | Species | Human | Gene symbol | RPL7 | Gene ID | 6129 |
Gene name | ribosomal protein L7 | |
Gene Alias | L7 | |
Cytomap | 8q21.11 | |
Gene Type | protein-coding | GO ID | GO:0000463 | UniProtAcc | P18124 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6129 | RPL7 | GSM4909285 | Human | Breast | IDC | 9.13e-07 | 1.53e-01 | 0.21 |
6129 | RPL7 | GSM4909286 | Human | Breast | IDC | 1.02e-51 | 2.83e-01 | 0.1081 |
6129 | RPL7 | GSM4909287 | Human | Breast | IDC | 1.01e-15 | -2.70e-01 | 0.2057 |
6129 | RPL7 | GSM4909290 | Human | Breast | IDC | 5.23e-19 | -2.37e-01 | 0.2096 |
6129 | RPL7 | GSM4909291 | Human | Breast | IDC | 2.47e-25 | 2.58e-01 | 0.1753 |
6129 | RPL7 | GSM4909293 | Human | Breast | IDC | 5.95e-41 | -2.27e-01 | 0.1581 |
6129 | RPL7 | GSM4909296 | Human | Breast | IDC | 3.40e-06 | 1.26e-01 | 0.1524 |
6129 | RPL7 | GSM4909298 | Human | Breast | IDC | 2.18e-11 | -1.08e-01 | 0.1551 |
6129 | RPL7 | GSM4909301 | Human | Breast | IDC | 2.47e-29 | -2.61e-01 | 0.1577 |
6129 | RPL7 | GSM4909302 | Human | Breast | IDC | 5.78e-03 | -1.53e-01 | 0.1545 |
6129 | RPL7 | GSM4909303 | Human | Breast | IDC | 3.38e-12 | -4.09e-01 | 0.0438 |
6129 | RPL7 | GSM4909304 | Human | Breast | IDC | 2.72e-67 | -3.92e-01 | 0.1636 |
6129 | RPL7 | GSM4909305 | Human | Breast | IDC | 3.00e-15 | 1.83e-01 | 0.0436 |
6129 | RPL7 | GSM4909306 | Human | Breast | IDC | 4.86e-12 | 1.65e-01 | 0.1564 |
6129 | RPL7 | GSM4909311 | Human | Breast | IDC | 6.77e-09 | 7.65e-02 | 0.1534 |
6129 | RPL7 | GSM4909312 | Human | Breast | IDC | 5.82e-46 | 2.81e-01 | 0.1552 |
6129 | RPL7 | GSM4909313 | Human | Breast | IDC | 1.30e-03 | -1.67e-01 | 0.0391 |
6129 | RPL7 | GSM4909315 | Human | Breast | IDC | 9.93e-45 | -4.46e-01 | 0.21 |
6129 | RPL7 | GSM4909316 | Human | Breast | IDC | 1.44e-27 | -7.29e-01 | 0.21 |
6129 | RPL7 | GSM4909317 | Human | Breast | IDC | 3.49e-26 | -2.77e-01 | 0.1355 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00422543 | Colorectum | MSI-H | ribosome biogenesis | 54/1319 | 299/18723 | 1.27e-10 | 2.07e-08 | 54 |
GO:00422733 | Colorectum | MSI-H | ribosomal large subunit biogenesis | 23/1319 | 72/18723 | 3.58e-10 | 5.23e-08 | 23 |
GO:00063641 | Colorectum | MSI-H | rRNA processing | 39/1319 | 225/18723 | 1.45e-07 | 1.32e-05 | 39 |
GO:00160721 | Colorectum | MSI-H | rRNA metabolic process | 39/1319 | 236/18723 | 5.20e-07 | 3.91e-05 | 39 |
GO:00004701 | Colorectum | MSI-H | maturation of LSU-rRNA | 10/1319 | 28/18723 | 1.18e-05 | 5.41e-04 | 10 |
GO:0034470 | Colorectum | MSI-H | ncRNA processing | 48/1319 | 395/18723 | 1.54e-04 | 4.47e-03 | 48 |
GO:0034660 | Colorectum | MSI-H | ncRNA metabolic process | 53/1319 | 485/18723 | 9.66e-04 | 1.68e-02 | 53 |
GO:00021814 | Colorectum | FAP | cytoplasmic translation | 76/2622 | 148/18723 | 3.31e-27 | 2.03e-23 | 76 |
GO:00017013 | Colorectum | FAP | in utero embryonic development | 81/2622 | 367/18723 | 1.58e-05 | 4.10e-04 | 81 |
GO:00226134 | Colorectum | FAP | ribonucleoprotein complex biogenesis | 91/2622 | 463/18723 | 4.28e-04 | 5.12e-03 | 91 |
GO:00021815 | Colorectum | CRC | cytoplasmic translation | 70/2078 | 148/18723 | 1.53e-28 | 9.16e-25 | 70 |
GO:00226135 | Colorectum | CRC | ribonucleoprotein complex biogenesis | 76/2078 | 463/18723 | 3.04e-04 | 4.78e-03 | 76 |
GO:000218116 | Endometrium | AEH | cytoplasmic translation | 104/2100 | 148/18723 | 1.01e-64 | 6.07e-61 | 104 |
GO:002261316 | Endometrium | AEH | ribonucleoprotein complex biogenesis | 107/2100 | 463/18723 | 1.43e-13 | 4.08e-11 | 107 |
GO:004227316 | Endometrium | AEH | ribosomal large subunit biogenesis | 30/2100 | 72/18723 | 3.69e-11 | 5.03e-09 | 30 |
GO:004225416 | Endometrium | AEH | ribosome biogenesis | 67/2100 | 299/18723 | 1.95e-08 | 1.18e-06 | 67 |
GO:00017019 | Endometrium | AEH | in utero embryonic development | 73/2100 | 367/18723 | 7.18e-07 | 2.63e-05 | 73 |
GO:00063648 | Endometrium | AEH | rRNA processing | 47/2100 | 225/18723 | 1.78e-05 | 3.65e-04 | 47 |
GO:00004704 | Endometrium | AEH | maturation of LSU-rRNA | 12/2100 | 28/18723 | 2.08e-05 | 4.13e-04 | 12 |
GO:00160728 | Endometrium | AEH | rRNA metabolic process | 48/2100 | 236/18723 | 3.01e-05 | 5.54e-04 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL7 | SNV | Missense_Mutation | novel | c.11N>G | p.Val4Gly | p.V4G | P18124 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPL7 | insertion | Frame_Shift_Ins | novel | c.273_274insCCATTTAGGGCAAAGCTTATGTGCATTCAGCAGCTTAGAG | p.Val92ProfsTer53 | p.V92Pfs*53 | P18124 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RPL7 | SNV | Missense_Mutation | novel | c.133N>A | p.Ala45Thr | p.A45T | P18124 | protein_coding | tolerated(0.13) | benign(0.082) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RPL7 | SNV | Missense_Mutation | novel | c.668N>G | p.Lys223Arg | p.K223R | P18124 | protein_coding | deleterious(0.02) | benign(0.157) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
RPL7 | SNV | Missense_Mutation | c.469N>T | p.Arg157Cys | p.R157C | P18124 | protein_coding | tolerated(0.09) | benign(0.068) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RPL7 | SNV | Missense_Mutation | c.65N>A | p.Arg22Gln | p.R22Q | P18124 | protein_coding | tolerated(0.26) | benign(0.202) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
RPL7 | SNV | Missense_Mutation | novel | c.118N>C | p.Lys40Gln | p.K40Q | P18124 | protein_coding | tolerated(0.06) | possibly_damaging(0.457) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RPL7 | SNV | Missense_Mutation | novel | c.269C>T | p.Ala90Val | p.A90V | P18124 | protein_coding | tolerated(0.16) | benign(0.044) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL7 | SNV | Missense_Mutation | c.128N>A | p.Arg43Gln | p.R43Q | P18124 | protein_coding | tolerated(0.39) | benign(0.025) | TCGA-AG-3742-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPL7 | SNV | Missense_Mutation | novel | c.698C>T | p.Ala233Val | p.A233V | P18124 | protein_coding | tolerated(0.24) | benign(0.178) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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