![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RPL10A |
Gene summary for RPL10A |
![]() |
Gene information | Species | Human | Gene symbol | RPL10A | Gene ID | 4736 |
Gene name | ribosomal protein L10a | |
Gene Alias | CSA19 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000470 | UniProtAcc | P62906 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4736 | RPL10A | CA_HPV_1 | Human | Cervix | CC | 8.13e-08 | -2.90e-01 | 0.0264 |
4736 | RPL10A | CA_HPV_2 | Human | Cervix | CC | 3.90e-23 | -3.50e-01 | 0.0391 |
4736 | RPL10A | CA_HPV_3 | Human | Cervix | CC | 2.72e-02 | 1.31e-01 | 0.0414 |
4736 | RPL10A | N_HPV_2 | Human | Cervix | N_HPV | 2.30e-02 | -9.41e-02 | -0.0131 |
4736 | RPL10A | CCI_1 | Human | Cervix | CC | 1.89e-47 | -1.66e+00 | 0.528 |
4736 | RPL10A | CCI_2 | Human | Cervix | CC | 7.76e-35 | -1.23e+00 | 0.5249 |
4736 | RPL10A | CCI_3 | Human | Cervix | CC | 1.38e-56 | -1.65e+00 | 0.516 |
4736 | RPL10A | CCII_1 | Human | Cervix | CC | 9.65e-80 | -1.80e+00 | 0.3249 |
4736 | RPL10A | Tumor | Human | Cervix | CC | 2.94e-36 | -3.81e-01 | 0.1241 |
4736 | RPL10A | sample1 | Human | Cervix | CC | 3.16e-03 | -2.24e-01 | 0.0959 |
4736 | RPL10A | sample3 | Human | Cervix | CC | 1.39e-63 | -4.69e-01 | 0.1387 |
4736 | RPL10A | H2 | Human | Cervix | HSIL_HPV | 8.10e-28 | -4.40e-01 | 0.0632 |
4736 | RPL10A | L1 | Human | Cervix | CC | 2.44e-02 | -2.33e-01 | 0.0802 |
4736 | RPL10A | T1 | Human | Cervix | CC | 5.01e-25 | -3.89e-01 | 0.0918 |
4736 | RPL10A | T3 | Human | Cervix | CC | 5.01e-70 | -4.93e-01 | 0.1389 |
4736 | RPL10A | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.44e-119 | 2.79e+00 | 0.0155 |
4736 | RPL10A | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.06e-48 | 2.88e+00 | -0.1808 |
4736 | RPL10A | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.01e-37 | 3.20e+00 | 0.0216 |
4736 | RPL10A | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.19e-64 | 3.06e+00 | -0.0811 |
4736 | RPL10A | HTA11_78_2000001011 | Human | Colorectum | AD | 1.93e-55 | 2.18e+00 | -0.1088 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001607216 | Endometrium | EEC | rRNA metabolic process | 49/2168 | 236/18723 | 3.27e-05 | 5.62e-04 | 49 |
GO:009730516 | Endometrium | EEC | response to alcohol | 49/2168 | 253/18723 | 1.99e-04 | 2.42e-03 | 49 |
GO:003447012 | Endometrium | EEC | ncRNA processing | 63/2168 | 395/18723 | 5.20e-03 | 3.26e-02 | 63 |
GO:000218127 | Esophagus | HGIN | cytoplasmic translation | 108/2587 | 148/18723 | 1.70e-60 | 1.02e-56 | 108 |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
GO:004227326 | Esophagus | HGIN | ribosomal large subunit biogenesis | 34/2587 | 72/18723 | 8.82e-12 | 1.06e-09 | 34 |
GO:001607219 | Esophagus | HGIN | rRNA metabolic process | 72/2587 | 236/18723 | 2.26e-11 | 2.56e-09 | 72 |
GO:000636419 | Esophagus | HGIN | rRNA processing | 69/2587 | 225/18723 | 4.53e-11 | 5.04e-09 | 69 |
GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
GO:009730520 | Esophagus | HGIN | response to alcohol | 54/2587 | 253/18723 | 6.46e-04 | 8.87e-03 | 54 |
GO:00004707 | Esophagus | HGIN | maturation of LSU-rRNA | 10/2587 | 28/18723 | 3.04e-03 | 2.88e-02 | 10 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0517145 | Cervix | N_HPV | Coronavirus disease - COVID-19 | 47/349 | 232/8465 | 1.79e-20 | 4.86e-18 | 3.80e-18 | 47 |
hsa0301045 | Cervix | N_HPV | Ribosome | 39/349 | 167/8465 | 2.05e-19 | 2.79e-17 | 2.18e-17 | 39 |
hsa0517155 | Cervix | N_HPV | Coronavirus disease - COVID-19 | 47/349 | 232/8465 | 1.79e-20 | 4.86e-18 | 3.80e-18 | 47 |
hsa0301055 | Cervix | N_HPV | Ribosome | 39/349 | 167/8465 | 2.05e-19 | 2.79e-17 | 2.18e-17 | 39 |
hsa03010 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa05171 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa030101 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa051711 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa030102 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa051712 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
hsa030103 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa051713 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
Page: 1 2 3 4 5 6 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL10A | SNV | Missense_Mutation | c.193N>C | p.Val65Leu | p.V65L | P62906 | protein_coding | tolerated(0.1) | benign(0.013) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RPL10A | SNV | Missense_Mutation | c.519N>T | p.Lys173Asn | p.K173N | P62906 | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
RPL10A | SNV | Missense_Mutation | c.497N>T | p.Ala166Val | p.A166V | P62906 | protein_coding | deleterious(0.04) | possibly_damaging(0.71) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RPL10A | deletion | Frame_Shift_Del | c.404delC | p.Pro135LeufsTer17 | p.P135Lfs*17 | P62906 | protein_coding | TCGA-AA-3692-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | PD | |||
RPL10A | SNV | Missense_Mutation | novel | c.284A>C | p.Lys95Thr | p.K95T | P62906 | protein_coding | deleterious(0.02) | probably_damaging(0.977) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
RPL10A | SNV | Missense_Mutation | novel | c.491N>A | p.Cys164Tyr | p.C164Y | P62906 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-BG-A2L7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
RPL10A | SNV | Missense_Mutation | c.404N>T | p.Pro135Leu | p.P135L | P62906 | protein_coding | deleterious(0.03) | possibly_damaging(0.738) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPL10A | SNV | Missense_Mutation | novel | c.644N>A | p.Arg215His | p.R215H | P62906 | protein_coding | tolerated(0.09) | benign(0.017) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
RPL10A | SNV | Missense_Mutation | c.292A>C | p.Lys98Gln | p.K98Q | P62906 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BC-A112-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
RPL10A | SNV | Missense_Mutation | novel | c.19N>G | p.Arg7Gly | p.R7G | P62906 | protein_coding | tolerated(0.4) | benign(0.015) | TCGA-DD-A1EE-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |