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Gene: ROMO1 |
Gene summary for ROMO1 |
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Gene information | Species | Human | Gene symbol | ROMO1 | Gene ID | 140823 |
Gene name | reactive oxygen species modulator 1 | |
Gene Alias | C20orf52 | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | P60602 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140823 | ROMO1 | GSM4909282 | Human | Breast | IDC | 6.21e-07 | 4.10e-01 | -0.0288 |
140823 | ROMO1 | GSM4909285 | Human | Breast | IDC | 5.08e-03 | -1.46e-01 | 0.21 |
140823 | ROMO1 | GSM4909287 | Human | Breast | IDC | 1.48e-04 | 3.42e-01 | 0.2057 |
140823 | ROMO1 | GSM4909290 | Human | Breast | IDC | 2.07e-07 | 4.35e-01 | 0.2096 |
140823 | ROMO1 | GSM4909291 | Human | Breast | IDC | 4.66e-06 | 4.26e-01 | 0.1753 |
140823 | ROMO1 | GSM4909293 | Human | Breast | IDC | 1.07e-09 | 3.28e-01 | 0.1581 |
140823 | ROMO1 | GSM4909294 | Human | Breast | IDC | 8.21e-10 | 3.48e-01 | 0.2022 |
140823 | ROMO1 | GSM4909296 | Human | Breast | IDC | 9.13e-13 | 3.29e-01 | 0.1524 |
140823 | ROMO1 | GSM4909297 | Human | Breast | IDC | 4.23e-08 | -3.25e-02 | 0.1517 |
140823 | ROMO1 | GSM4909298 | Human | Breast | IDC | 1.69e-06 | 3.24e-01 | 0.1551 |
140823 | ROMO1 | GSM4909299 | Human | Breast | IDC | 8.40e-05 | 2.82e-01 | 0.035 |
140823 | ROMO1 | GSM4909301 | Human | Breast | IDC | 3.37e-20 | 5.44e-01 | 0.1577 |
140823 | ROMO1 | GSM4909304 | Human | Breast | IDC | 2.07e-25 | 6.23e-01 | 0.1636 |
140823 | ROMO1 | GSM4909307 | Human | Breast | IDC | 6.91e-03 | 3.00e-01 | 0.1569 |
140823 | ROMO1 | GSM4909308 | Human | Breast | IDC | 6.62e-05 | 2.11e-01 | 0.158 |
140823 | ROMO1 | GSM4909309 | Human | Breast | IDC | 4.53e-10 | 3.72e-01 | 0.0483 |
140823 | ROMO1 | GSM4909311 | Human | Breast | IDC | 3.14e-37 | 2.49e-01 | 0.1534 |
140823 | ROMO1 | GSM4909312 | Human | Breast | IDC | 6.53e-08 | 1.35e-01 | 0.1552 |
140823 | ROMO1 | GSM4909315 | Human | Breast | IDC | 1.16e-23 | 6.34e-01 | 0.21 |
140823 | ROMO1 | GSM4909316 | Human | Breast | IDC | 2.38e-15 | 6.16e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265522 | Breast | DCIS | establishment of protein localization to mitochondrion | 22/1390 | 120/18723 | 6.60e-05 | 1.31e-03 | 22 |
GO:000660523 | Breast | DCIS | protein targeting | 43/1390 | 314/18723 | 7.17e-05 | 1.41e-03 | 43 |
GO:000700622 | Breast | DCIS | mitochondrial membrane organization | 21/1390 | 116/18723 | 1.16e-04 | 2.03e-03 | 21 |
GO:003461423 | Breast | DCIS | cellular response to reactive oxygen species | 25/1390 | 155/18723 | 1.88e-04 | 3.05e-03 | 25 |
GO:001973021 | Breast | DCIS | antimicrobial humoral response | 21/1390 | 122/18723 | 2.40e-04 | 3.75e-03 | 21 |
GO:007259423 | Breast | DCIS | establishment of protein localization to organelle | 51/1390 | 422/18723 | 3.91e-04 | 5.40e-03 | 51 |
GO:200037922 | Breast | DCIS | positive regulation of reactive oxygen species metabolic process | 15/1390 | 76/18723 | 4.06e-04 | 5.54e-03 | 15 |
GO:006184421 | Breast | DCIS | antimicrobial humoral immune response mediated by antimicrobial peptide | 15/1390 | 79/18723 | 6.25e-04 | 7.87e-03 | 15 |
GO:000662622 | Breast | DCIS | protein targeting to mitochondrion | 17/1390 | 100/18723 | 1.05e-03 | 1.15e-02 | 17 |
GO:007180621 | Breast | DCIS | protein transmembrane transport | 12/1390 | 59/18723 | 1.14e-03 | 1.22e-02 | 12 |
GO:009015121 | Breast | DCIS | establishment of protein localization to mitochondrial membrane | 8/1390 | 30/18723 | 1.21e-03 | 1.28e-02 | 8 |
GO:200037723 | Breast | DCIS | regulation of reactive oxygen species metabolic process | 23/1390 | 157/18723 | 1.31e-03 | 1.37e-02 | 23 |
GO:005170212 | Breast | DCIS | biological process involved in interaction with symbiont | 16/1390 | 94/18723 | 1.43e-03 | 1.46e-02 | 16 |
GO:000756921 | Breast | DCIS | cell aging | 19/1390 | 132/18723 | 4.03e-03 | 3.20e-02 | 19 |
GO:000695911 | Breast | DCIS | humoral immune response | 37/1390 | 317/18723 | 4.16e-03 | 3.29e-02 | 37 |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:000697910 | Cervix | CC | response to oxidative stress | 102/2311 | 446/18723 | 2.99e-10 | 4.36e-08 | 102 |
GO:004440310 | Cervix | CC | biological process involved in symbiotic interaction | 71/2311 | 290/18723 | 7.94e-09 | 6.98e-07 | 71 |
GO:000030210 | Cervix | CC | response to reactive oxygen species | 56/2311 | 222/18723 | 1.00e-07 | 5.25e-06 | 56 |
GO:006219710 | Cervix | CC | cellular response to chemical stress | 76/2311 | 337/18723 | 1.01e-07 | 5.25e-06 | 76 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ROMO1 | SNV | Missense_Mutation | c.172N>G | p.Lys58Glu | p.K58E | P60602 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ROMO1 | SNV | Missense_Mutation | novel | c.142C>T | p.Arg48Trp | p.R48W | P60602 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ROMO1 | SNV | Missense_Mutation | novel | c.186N>C | p.Gln62His | p.Q62H | P60602 | protein_coding | deleterious(0.04) | benign(0.425) | TCGA-85-A4QQ-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ROMO1 | SNV | Missense_Mutation | rs749056787 | c.193N>A | p.Gly65Ser | p.G65S | P60602 | protein_coding | tolerated(0.16) | benign(0.056) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
ROMO1 | SNV | Missense_Mutation | novel | c.37N>A | p.Pro13Thr | p.P13T | P60602 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-VQ-AA68-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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