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Gene: PPP1R2 |
Gene summary for PPP1R2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PPP1R2 | Gene ID | 5504 |
| Gene name | protein phosphatase 1 regulatory inhibitor subunit 2 | |
| Gene Alias | IPP-2 | |
| Cytomap | 3q29 | |
| Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | P41236 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 5504 | PPP1R2 | LZE2T | Human | Esophagus | ESCC | 4.64e-09 | 8.91e-01 | 0.082 |
| 5504 | PPP1R2 | LZE4T | Human | Esophagus | ESCC | 1.51e-40 | 1.58e+00 | 0.0811 |
| 5504 | PPP1R2 | LZE7T | Human | Esophagus | ESCC | 2.26e-21 | 1.46e+00 | 0.0667 |
| 5504 | PPP1R2 | LZE8T | Human | Esophagus | ESCC | 1.63e-22 | 8.29e-01 | 0.067 |
| 5504 | PPP1R2 | LZE20T | Human | Esophagus | ESCC | 1.86e-13 | 6.48e-01 | 0.0662 |
| 5504 | PPP1R2 | LZE22D1 | Human | Esophagus | HGIN | 9.73e-04 | 1.68e-01 | 0.0595 |
| 5504 | PPP1R2 | LZE22T | Human | Esophagus | ESCC | 1.47e-02 | 7.57e-01 | 0.068 |
| 5504 | PPP1R2 | LZE24T | Human | Esophagus | ESCC | 4.27e-43 | 1.47e+00 | 0.0596 |
| 5504 | PPP1R2 | LZE21T | Human | Esophagus | ESCC | 1.75e-18 | 1.85e+00 | 0.0655 |
| 5504 | PPP1R2 | LZE6T | Human | Esophagus | ESCC | 9.01e-20 | 1.22e+00 | 0.0845 |
| 5504 | PPP1R2 | P1T-E | Human | Esophagus | ESCC | 2.16e-20 | 1.30e+00 | 0.0875 |
| 5504 | PPP1R2 | P2T-E | Human | Esophagus | ESCC | 8.05e-100 | 1.97e+00 | 0.1177 |
| 5504 | PPP1R2 | P4T-E | Human | Esophagus | ESCC | 9.74e-79 | 2.34e+00 | 0.1323 |
| 5504 | PPP1R2 | P5T-E | Human | Esophagus | ESCC | 1.07e-65 | 1.70e+00 | 0.1327 |
| 5504 | PPP1R2 | P8T-E | Human | Esophagus | ESCC | 1.82e-56 | 1.08e+00 | 0.0889 |
| 5504 | PPP1R2 | P9T-E | Human | Esophagus | ESCC | 1.54e-52 | 1.44e+00 | 0.1131 |
| 5504 | PPP1R2 | P10T-E | Human | Esophagus | ESCC | 6.16e-56 | 1.12e+00 | 0.116 |
| 5504 | PPP1R2 | P11T-E | Human | Esophagus | ESCC | 6.64e-27 | 1.30e+00 | 0.1426 |
| 5504 | PPP1R2 | P12T-E | Human | Esophagus | ESCC | 2.24e-66 | 1.39e+00 | 0.1122 |
| 5504 | PPP1R2 | P15T-E | Human | Esophagus | ESCC | 2.65e-67 | 1.74e+00 | 0.1149 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:001631114 | Oral cavity | EOLP | dephosphorylation | 85/2218 | 417/18723 | 3.19e-07 | 9.47e-06 | 85 |
| GO:001092114 | Oral cavity | EOLP | regulation of phosphatase activity | 25/2218 | 84/18723 | 8.43e-06 | 1.61e-04 | 25 |
| GO:000609125 | Oral cavity | EOLP | generation of precursor metabolites and energy | 79/2218 | 490/18723 | 2.65e-03 | 1.59e-02 | 79 |
| GO:001598025 | Oral cavity | EOLP | energy derivation by oxidation of organic compounds | 54/2218 | 318/18723 | 4.02e-03 | 2.23e-02 | 54 |
| GO:000647032 | Oral cavity | NEOLP | protein dephosphorylation | 54/2005 | 281/18723 | 1.44e-05 | 2.53e-04 | 54 |
| GO:001598033 | Oral cavity | NEOLP | energy derivation by oxidation of organic compounds | 59/2005 | 318/18723 | 1.78e-05 | 3.01e-04 | 59 |
| GO:000609133 | Oral cavity | NEOLP | generation of precursor metabolites and energy | 82/2005 | 490/18723 | 2.70e-05 | 4.22e-04 | 82 |
| GO:003530432 | Oral cavity | NEOLP | regulation of protein dephosphorylation | 22/2005 | 90/18723 | 1.59e-04 | 1.78e-03 | 22 |
| GO:004366632 | Oral cavity | NEOLP | regulation of phosphoprotein phosphatase activity | 16/2005 | 58/18723 | 2.81e-04 | 2.81e-03 | 16 |
| GO:003530331 | Oral cavity | NEOLP | regulation of dephosphorylation | 27/2005 | 128/18723 | 4.22e-04 | 3.89e-03 | 27 |
| GO:001092122 | Oral cavity | NEOLP | regulation of phosphatase activity | 19/2005 | 84/18723 | 1.20e-03 | 8.85e-03 | 19 |
| GO:001631122 | Oral cavity | NEOLP | dephosphorylation | 64/2005 | 417/18723 | 1.98e-03 | 1.33e-02 | 64 |
| GO:0006091111 | Skin | cSCC | generation of precursor metabolites and energy | 224/4864 | 490/18723 | 1.13e-21 | 2.21e-19 | 224 |
| GO:001598026 | Skin | cSCC | energy derivation by oxidation of organic compounds | 154/4864 | 318/18723 | 4.19e-18 | 5.15e-16 | 154 |
| GO:000647024 | Skin | cSCC | protein dephosphorylation | 111/4864 | 281/18723 | 4.10e-07 | 7.96e-06 | 111 |
| GO:0035304112 | Skin | cSCC | regulation of protein dephosphorylation | 41/4864 | 90/18723 | 4.61e-05 | 4.80e-04 | 41 |
| GO:0035303112 | Skin | cSCC | regulation of dephosphorylation | 49/4864 | 128/18723 | 1.46e-03 | 9.17e-03 | 49 |
| GO:001631115 | Skin | cSCC | dephosphorylation | 134/4864 | 417/18723 | 2.65e-03 | 1.50e-02 | 134 |
| GO:0006091112 | Thyroid | PTC | generation of precursor metabolites and energy | 252/5968 | 490/18723 | 8.24e-20 | 1.13e-17 | 252 |
| GO:0015980111 | Thyroid | PTC | energy derivation by oxidation of organic compounds | 176/5968 | 318/18723 | 2.67e-18 | 2.90e-16 | 176 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PPP1R2 | insertion | In_Frame_Ins | novel | c.32_33insGAAGCAGGA | p.Ile11delinsMetLysGlnAsp | p.I11delinsMKQD | P41236 | protein_coding | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
| PPP1R2 | insertion | Nonsense_Mutation | novel | c.356_357insGTAGATAGCTTAGGG | p.Gln119_Glu120insTer | p.Q119_E120ins* | P41236 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| PPP1R2 | SNV | Missense_Mutation | rs751525820 | c.344N>A | p.Arg115Gln | p.R115Q | P41236 | protein_coding | tolerated(0.93) | benign(0.005) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PPP1R2 | SNV | Missense_Mutation | c.254N>T | p.Ala85Val | p.A85V | P41236 | protein_coding | tolerated(0.1) | benign(0.373) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| PPP1R2 | SNV | Missense_Mutation | c.287N>T | p.Ala96Val | p.A96V | P41236 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
| PPP1R2 | SNV | Missense_Mutation | rs751525820 | c.344N>A | p.Arg115Gln | p.R115Q | P41236 | protein_coding | tolerated(0.93) | benign(0.005) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| PPP1R2 | SNV | Missense_Mutation | c.388N>A | p.Ser130Thr | p.S130T | P41236 | protein_coding | tolerated(0.44) | benign(0.033) | TCGA-AG-3728-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | CR | |
| PPP1R2 | SNV | Missense_Mutation | c.493N>A | p.Leu165Ile | p.L165I | P41236 | protein_coding | deleterious(0.02) | probably_damaging(0.953) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| PPP1R2 | SNV | Missense_Mutation | novel | c.292N>T | p.Asp98Tyr | p.D98Y | P41236 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| PPP1R2 | SNV | Missense_Mutation | novel | c.436N>T | p.Leu146Phe | p.L146F | P41236 | protein_coding | deleterious(0) | possibly_damaging(0.877) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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