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Gene: POLR2I |
Gene summary for POLR2I |
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Gene information | Species | Human | Gene symbol | POLR2I | Gene ID | 5438 |
Gene name | RNA polymerase II subunit I | |
Gene Alias | RPB9 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0001192 | UniProtAcc | P36954 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5438 | POLR2I | CA_HPV_1 | Human | Cervix | CC | 1.26e-06 | -2.94e-01 | 0.0264 |
5438 | POLR2I | N_HPV_1 | Human | Cervix | N_HPV | 3.35e-02 | -1.81e-01 | 0.0079 |
5438 | POLR2I | CCI_1 | Human | Cervix | CC | 2.69e-05 | -5.04e-01 | 0.528 |
5438 | POLR2I | CCI_2 | Human | Cervix | CC | 3.56e-08 | -5.44e-01 | 0.5249 |
5438 | POLR2I | CCI_3 | Human | Cervix | CC | 4.19e-12 | -5.44e-01 | 0.516 |
5438 | POLR2I | CCII_1 | Human | Cervix | CC | 6.47e-17 | -5.44e-01 | 0.3249 |
5438 | POLR2I | Tumor | Human | Cervix | CC | 2.58e-09 | 4.20e-01 | 0.1241 |
5438 | POLR2I | sample3 | Human | Cervix | CC | 6.26e-10 | 3.47e-01 | 0.1387 |
5438 | POLR2I | L1 | Human | Cervix | CC | 2.91e-04 | -1.86e-01 | 0.0802 |
5438 | POLR2I | T3 | Human | Cervix | CC | 7.59e-13 | 3.84e-01 | 0.1389 |
5438 | POLR2I | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.08e-08 | 1.93e-01 | 0.0155 |
5438 | POLR2I | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.17e-11 | 3.02e-01 | -0.1808 |
5438 | POLR2I | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.85e-14 | 3.96e-01 | -0.0811 |
5438 | POLR2I | HTA11_78_2000001011 | Human | Colorectum | AD | 4.96e-02 | 9.29e-02 | -0.1088 |
5438 | POLR2I | HTA11_347_2000001011 | Human | Colorectum | AD | 9.61e-11 | 2.30e-01 | -0.1954 |
5438 | POLR2I | HTA11_411_2000001011 | Human | Colorectum | SER | 4.01e-04 | 3.62e-01 | -0.2602 |
5438 | POLR2I | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.86e-11 | 3.24e-01 | -0.1207 |
5438 | POLR2I | HTA11_83_2000001011 | Human | Colorectum | SER | 2.04e-02 | 1.29e-01 | -0.1526 |
5438 | POLR2I | HTA11_696_2000001011 | Human | Colorectum | AD | 4.70e-13 | 2.82e-01 | -0.1464 |
5438 | POLR2I | HTA11_866_2000001011 | Human | Colorectum | AD | 9.55e-09 | 2.23e-01 | -0.1001 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00903055 | Thyroid | PTC | nucleic acid phosphodiester bond hydrolysis | 105/5968 | 261/18723 | 2.53e-03 | 1.31e-02 | 105 |
GO:000635421 | Thyroid | ATC | DNA-templated transcription, elongation | 63/6293 | 91/18723 | 3.89e-12 | 1.55e-10 | 63 |
GO:000636822 | Thyroid | ATC | transcription elongation from RNA polymerase II promoter | 49/6293 | 69/18723 | 2.32e-10 | 6.72e-09 | 49 |
GO:000636712 | Thyroid | ATC | transcription initiation from RNA polymerase II promoter | 44/6293 | 77/18723 | 1.86e-05 | 1.70e-04 | 44 |
GO:009050112 | Thyroid | ATC | RNA phosphodiester bond hydrolysis | 76/6293 | 152/18723 | 2.07e-05 | 1.86e-04 | 76 |
GO:000635213 | Thyroid | ATC | DNA-templated transcription, initiation | 64/6293 | 130/18723 | 1.60e-04 | 1.10e-03 | 64 |
GO:009030511 | Thyroid | ATC | nucleic acid phosphodiester bond hydrolysis | 107/6293 | 261/18723 | 7.21e-03 | 2.84e-02 | 107 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501618 | Cervix | CC | Huntington disease | 94/1267 | 306/8465 | 8.49e-13 | 3.06e-11 | 1.81e-11 | 94 |
hsa0501619 | Cervix | CC | Huntington disease | 94/1267 | 306/8465 | 8.49e-13 | 3.06e-11 | 1.81e-11 | 94 |
hsa0501644 | Cervix | N_HPV | Huntington disease | 36/349 | 306/8465 | 9.73e-09 | 2.65e-07 | 2.07e-07 | 36 |
hsa0501654 | Cervix | N_HPV | Huntington disease | 36/349 | 306/8465 | 9.73e-09 | 2.65e-07 | 2.07e-07 | 36 |
hsa05016 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa050161 | Colorectum | AD | Huntington disease | 147/2092 | 306/8465 | 1.93e-19 | 9.26e-18 | 5.91e-18 | 147 |
hsa050162 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa050163 | Colorectum | SER | Huntington disease | 127/1580 | 306/8465 | 3.29e-21 | 1.37e-19 | 9.92e-20 | 127 |
hsa050164 | Colorectum | MSS | Huntington disease | 141/1875 | 306/8465 | 2.90e-21 | 1.62e-19 | 9.92e-20 | 141 |
hsa050165 | Colorectum | MSS | Huntington disease | 141/1875 | 306/8465 | 2.90e-21 | 1.62e-19 | 9.92e-20 | 141 |
hsa050166 | Colorectum | MSI-H | Huntington disease | 83/797 | 306/8465 | 7.06e-20 | 3.81e-18 | 3.20e-18 | 83 |
hsa050167 | Colorectum | MSI-H | Huntington disease | 83/797 | 306/8465 | 7.06e-20 | 3.81e-18 | 3.20e-18 | 83 |
hsa0501620 | Endometrium | AEH | Huntington disease | 118/1197 | 306/8465 | 3.00e-27 | 2.44e-25 | 1.78e-25 | 118 |
hsa05016110 | Endometrium | AEH | Huntington disease | 118/1197 | 306/8465 | 3.00e-27 | 2.44e-25 | 1.78e-25 | 118 |
hsa0501625 | Endometrium | EEC | Huntington disease | 120/1237 | 306/8465 | 3.86e-27 | 4.23e-25 | 3.15e-25 | 120 |
hsa0501635 | Endometrium | EEC | Huntington disease | 120/1237 | 306/8465 | 3.86e-27 | 4.23e-25 | 3.15e-25 | 120 |
hsa0501630 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
hsa034205 | Esophagus | HGIN | Nucleotide excision repair | 29/1383 | 63/8465 | 2.96e-08 | 5.36e-07 | 4.26e-07 | 29 |
hsa030205 | Esophagus | HGIN | RNA polymerase | 12/1383 | 34/8465 | 5.62e-03 | 3.99e-02 | 3.17e-02 | 12 |
hsa05016113 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLR2I | insertion | Frame_Shift_Ins | novel | c.258_259insTTGA | p.Gln87LeufsTer49 | p.Q87Lfs*49 | P36954 | protein_coding | TCGA-A8-A0A6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR | ||
POLR2I | insertion | Frame_Shift_Ins | novel | c.257_258insTTGGCCAGGCTGGT | p.Gln87TrpfsTer? | p.Q87Wfs*? | P36954 | protein_coding | TCGA-A8-A0A6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR | ||
POLR2I | SNV | Missense_Mutation | c.305C>T | p.Ala102Val | p.A102V | P36954 | protein_coding | tolerated(0.2) | benign(0.021) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
POLR2I | SNV | Missense_Mutation | c.347N>T | p.Ala116Val | p.A116V | P36954 | protein_coding | tolerated(0.07) | benign(0.012) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
POLR2I | SNV | Missense_Mutation | novel | c.346N>A | p.Ala116Thr | p.A116T | P36954 | protein_coding | tolerated(0.11) | benign(0.138) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POLR2I | SNV | Missense_Mutation | novel | c.86N>G | p.Asp29Gly | p.D29G | P36954 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POLR2I | SNV | Missense_Mutation | novel | c.325C>T | p.Arg109Cys | p.R109C | P36954 | protein_coding | tolerated(0.05) | benign(0.062) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
POLR2I | SNV | Missense_Mutation | novel | c.223N>T | p.Asp75Tyr | p.D75Y | P36954 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
POLR2I | SNV | Missense_Mutation | novel | c.249N>A | p.Asp83Glu | p.D83E | P36954 | protein_coding | tolerated(0.41) | benign(0.022) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POLR2I | SNV | Missense_Mutation | c.236C>A | p.Pro79Gln | p.P79Q | P36954 | protein_coding | deleterious(0) | possibly_damaging(0.884) | TCGA-EP-A2KA-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | sorafenib | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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