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Gene: POLDIP2 |
Gene summary for POLDIP2 |
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Gene information | Species | Human | Gene symbol | POLDIP2 | Gene ID | 26073 |
Gene name | DNA polymerase delta interacting protein 2 | |
Gene Alias | PDIP38 | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B4DEM9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26073 | POLDIP2 | GSM4909286 | Human | Breast | IDC | 2.35e-04 | 1.50e-01 | 0.1081 |
26073 | POLDIP2 | GSM4909294 | Human | Breast | IDC | 1.72e-02 | 2.35e-01 | 0.2022 |
26073 | POLDIP2 | GSM4909311 | Human | Breast | IDC | 3.14e-09 | -8.46e-02 | 0.1534 |
26073 | POLDIP2 | GSM4909312 | Human | Breast | IDC | 1.02e-04 | 4.98e-02 | 0.1552 |
26073 | POLDIP2 | GSM4909319 | Human | Breast | IDC | 2.84e-20 | 8.76e-02 | 0.1563 |
26073 | POLDIP2 | GSM4909321 | Human | Breast | IDC | 1.84e-03 | 4.08e-02 | 0.1559 |
26073 | POLDIP2 | brca1 | Human | Breast | Precancer | 1.16e-03 | 1.95e-01 | -0.0338 |
26073 | POLDIP2 | brca2 | Human | Breast | Precancer | 4.46e-04 | 2.03e-01 | -0.024 |
26073 | POLDIP2 | NCCBC2 | Human | Breast | DCIS | 3.70e-07 | 5.42e-01 | 0.1554 |
26073 | POLDIP2 | NCCBC5 | Human | Breast | DCIS | 2.15e-07 | 2.88e-01 | 0.2046 |
26073 | POLDIP2 | P1 | Human | Breast | IDC | 2.63e-02 | -2.86e-02 | 0.1527 |
26073 | POLDIP2 | DCIS2 | Human | Breast | DCIS | 5.37e-28 | 4.47e-02 | 0.0085 |
26073 | POLDIP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.02e-05 | 1.34e-01 | 0.0155 |
26073 | POLDIP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.80e-06 | 2.90e-01 | -0.1808 |
26073 | POLDIP2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.08e-04 | 3.48e-01 | -0.0811 |
26073 | POLDIP2 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.05e-02 | 1.75e-01 | -0.1088 |
26073 | POLDIP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.72e-11 | 3.72e-01 | -0.1954 |
26073 | POLDIP2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.69e-04 | 5.57e-01 | -0.2602 |
26073 | POLDIP2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.06e-03 | 2.66e-01 | -0.1207 |
26073 | POLDIP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.15e-08 | 3.04e-01 | -0.1464 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1902850 | Colorectum | AD | microtubule cytoskeleton organization involved in mitosis | 48/3918 | 147/18723 | 5.87e-04 | 6.21e-03 | 48 |
GO:0010507 | Colorectum | AD | negative regulation of autophagy | 31/3918 | 85/18723 | 6.91e-04 | 7.05e-03 | 31 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:0090307 | Colorectum | AD | mitotic spindle assembly | 25/3918 | 65/18723 | 9.12e-04 | 8.71e-03 | 25 |
GO:0007052 | Colorectum | AD | mitotic spindle organization | 40/3918 | 120/18723 | 1.03e-03 | 9.61e-03 | 40 |
GO:0051893 | Colorectum | AD | regulation of focal adhesion assembly | 25/3918 | 66/18723 | 1.18e-03 | 1.06e-02 | 25 |
GO:0090109 | Colorectum | AD | regulation of cell-substrate junction assembly | 25/3918 | 66/18723 | 1.18e-03 | 1.06e-02 | 25 |
GO:0071897 | Colorectum | AD | DNA biosynthetic process | 55/3918 | 180/18723 | 1.46e-03 | 1.24e-02 | 55 |
GO:1901888 | Colorectum | AD | regulation of cell junction assembly | 61/3918 | 204/18723 | 1.50e-03 | 1.27e-02 | 61 |
GO:0000281 | Colorectum | AD | mitotic cytokinesis | 25/3918 | 71/18723 | 3.77e-03 | 2.65e-02 | 25 |
GO:0051225 | Colorectum | AD | spindle assembly | 37/3918 | 117/18723 | 4.32e-03 | 2.96e-02 | 37 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:0045931 | Colorectum | AD | positive regulation of mitotic cell cycle | 37/3918 | 121/18723 | 7.88e-03 | 4.73e-02 | 37 |
GO:00510981 | Colorectum | SER | regulation of binding | 97/2897 | 363/18723 | 1.98e-08 | 1.43e-06 | 97 |
GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
GO:00108101 | Colorectum | SER | regulation of cell-substrate adhesion | 64/2897 | 221/18723 | 2.34e-07 | 1.29e-05 | 64 |
GO:00098951 | Colorectum | SER | negative regulation of catabolic process | 84/2897 | 320/18723 | 3.93e-07 | 2.06e-05 | 84 |
GO:00108111 | Colorectum | SER | positive regulation of cell-substrate adhesion | 41/2897 | 123/18723 | 6.52e-07 | 3.15e-05 | 41 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLDIP2 | SNV | Missense_Mutation | novel | c.326C>A | p.Ser109Tyr | p.S109Y | Q9Y2S7 | protein_coding | tolerated(0.23) | benign(0.112) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
POLDIP2 | SNV | Missense_Mutation | novel | c.596N>T | p.Arg199Ile | p.R199I | Q9Y2S7 | protein_coding | deleterious(0) | benign(0.306) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
POLDIP2 | SNV | Missense_Mutation | novel | c.359N>A | p.Gly120Asp | p.G120D | Q9Y2S7 | protein_coding | tolerated(0.31) | benign(0.035) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
POLDIP2 | SNV | Missense_Mutation | novel | c.1013N>T | p.Arg338Ile | p.R338I | Q9Y2S7 | protein_coding | deleterious(0) | probably_damaging(0.909) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POLDIP2 | SNV | Missense_Mutation | novel | c.601N>A | p.Leu201Ile | p.L201I | Q9Y2S7 | protein_coding | deleterious(0.04) | probably_damaging(0.934) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
POLDIP2 | SNV | Missense_Mutation | novel | c.262N>G | p.Phe88Val | p.F88V | Q9Y2S7 | protein_coding | deleterious(0) | possibly_damaging(0.521) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POLDIP2 | SNV | Missense_Mutation | rs782542378 | c.844N>T | p.Arg282Trp | p.R282W | Q9Y2S7 | protein_coding | deleterious(0.01) | probably_damaging(0.913) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
POLDIP2 | SNV | Missense_Mutation | novel | c.455N>T | p.Thr152Ile | p.T152I | Q9Y2S7 | protein_coding | deleterious(0.01) | benign(0.084) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
POLDIP2 | SNV | Missense_Mutation | novel | c.1033G>C | p.Asp345His | p.D345H | Q9Y2S7 | protein_coding | deleterious(0) | possibly_damaging(0.718) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
POLDIP2 | SNV | Missense_Mutation | novel | c.1057C>A | p.Leu353Met | p.L353M | Q9Y2S7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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