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Gene: PEX13 |
Gene summary for PEX13 |
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Gene information | Species | Human | Gene symbol | PEX13 | Gene ID | 5194 |
Gene name | peroxisomal biogenesis factor 13 | |
Gene Alias | NALD | |
Cytomap | 2p15 | |
Gene Type | protein-coding | GO ID | GO:0001561 | UniProtAcc | Q92968 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5194 | PEX13 | LZE2T | Human | Esophagus | ESCC | 1.94e-03 | 4.83e-01 | 0.082 |
5194 | PEX13 | LZE4T | Human | Esophagus | ESCC | 1.14e-20 | 7.06e-01 | 0.0811 |
5194 | PEX13 | LZE7T | Human | Esophagus | ESCC | 1.43e-04 | 2.10e-01 | 0.0667 |
5194 | PEX13 | LZE20T | Human | Esophagus | ESCC | 9.97e-10 | 2.66e-01 | 0.0662 |
5194 | PEX13 | LZE24T | Human | Esophagus | ESCC | 3.65e-19 | 4.89e-01 | 0.0596 |
5194 | PEX13 | LZE21T | Human | Esophagus | ESCC | 3.45e-06 | 3.25e-01 | 0.0655 |
5194 | PEX13 | LZE6T | Human | Esophagus | ESCC | 1.62e-07 | 9.54e-02 | 0.0845 |
5194 | PEX13 | P1T-E | Human | Esophagus | ESCC | 3.52e-05 | 3.86e-01 | 0.0875 |
5194 | PEX13 | P2T-E | Human | Esophagus | ESCC | 1.74e-30 | 5.17e-01 | 0.1177 |
5194 | PEX13 | P4T-E | Human | Esophagus | ESCC | 3.68e-26 | 5.85e-01 | 0.1323 |
5194 | PEX13 | P5T-E | Human | Esophagus | ESCC | 7.32e-16 | 2.15e-01 | 0.1327 |
5194 | PEX13 | P8T-E | Human | Esophagus | ESCC | 4.57e-25 | 4.01e-01 | 0.0889 |
5194 | PEX13 | P9T-E | Human | Esophagus | ESCC | 2.18e-12 | 3.11e-01 | 0.1131 |
5194 | PEX13 | P10T-E | Human | Esophagus | ESCC | 4.38e-29 | 3.65e-01 | 0.116 |
5194 | PEX13 | P11T-E | Human | Esophagus | ESCC | 1.18e-18 | 9.26e-01 | 0.1426 |
5194 | PEX13 | P12T-E | Human | Esophagus | ESCC | 2.01e-20 | 4.25e-01 | 0.1122 |
5194 | PEX13 | P15T-E | Human | Esophagus | ESCC | 2.82e-35 | 7.55e-01 | 0.1149 |
5194 | PEX13 | P16T-E | Human | Esophagus | ESCC | 9.96e-35 | 4.59e-01 | 0.1153 |
5194 | PEX13 | P17T-E | Human | Esophagus | ESCC | 7.90e-03 | 2.20e-01 | 0.1278 |
5194 | PEX13 | P19T-E | Human | Esophagus | ESCC | 5.81e-04 | 4.74e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00344406 | Oral cavity | OSCC | lipid oxidation | 59/7305 | 108/18723 | 7.01e-04 | 3.89e-03 | 59 |
GO:0006625 | Oral cavity | OSCC | protein targeting to peroxisome | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
GO:0072662 | Oral cavity | OSCC | protein localization to peroxisome | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
GO:0072663 | Oral cavity | OSCC | establishment of protein localization to peroxisome | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
GO:0043574 | Oral cavity | OSCC | peroxisomal transport | 16/7305 | 22/18723 | 1.40e-03 | 6.79e-03 | 16 |
GO:00070312 | Oral cavity | OSCC | peroxisome organization | 23/7305 | 36/18723 | 2.19e-03 | 9.95e-03 | 23 |
GO:00442826 | Oral cavity | OSCC | small molecule catabolic process | 174/7305 | 376/18723 | 2.25e-03 | 1.00e-02 | 174 |
GO:00442426 | Oral cavity | OSCC | cellular lipid catabolic process | 104/7305 | 214/18723 | 2.61e-03 | 1.15e-02 | 104 |
GO:0015919 | Oral cavity | OSCC | peroxisomal membrane transport | 14/7305 | 20/18723 | 4.95e-03 | 1.94e-02 | 14 |
GO:00219876 | Oral cavity | OSCC | cerebral cortex development | 57/7305 | 114/18723 | 1.09e-02 | 3.71e-02 | 57 |
GO:00215435 | Oral cavity | OSCC | pallium development | 81/7305 | 169/18723 | 1.11e-02 | 3.76e-02 | 81 |
GO:007259419 | Oral cavity | LP | establishment of protein localization to organelle | 205/4623 | 422/18723 | 6.76e-27 | 3.85e-24 | 205 |
GO:0006605110 | Oral cavity | LP | protein targeting | 156/4623 | 314/18723 | 5.43e-22 | 1.62e-19 | 156 |
GO:001703816 | Oral cavity | LP | protein import | 95/4623 | 206/18723 | 1.55e-11 | 1.13e-09 | 95 |
GO:007180615 | Oral cavity | LP | protein transmembrane transport | 36/4623 | 59/18723 | 3.37e-09 | 1.44e-07 | 36 |
GO:006500213 | Oral cavity | LP | intracellular protein transmembrane transport | 31/4623 | 51/18723 | 4.70e-08 | 1.64e-06 | 31 |
GO:004474311 | Oral cavity | LP | protein transmembrane import into intracellular organelle | 22/4623 | 36/18723 | 3.76e-06 | 7.90e-05 | 22 |
GO:00070311 | Oral cavity | LP | peroxisome organization | 17/4623 | 36/18723 | 2.74e-03 | 1.92e-02 | 17 |
GO:004424213 | Oral cavity | LP | cellular lipid catabolic process | 70/4623 | 214/18723 | 4.82e-03 | 3.05e-02 | 70 |
GO:00066251 | Oral cavity | LP | protein targeting to peroxisome | 10/4623 | 18/18723 | 4.91e-03 | 3.06e-02 | 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041467 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa0414612 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa04146 | Liver | NAFLD | Peroxisome | 19/1043 | 82/8465 | 4.37e-03 | 4.10e-02 | 3.30e-02 | 19 |
hsa041461 | Liver | NAFLD | Peroxisome | 19/1043 | 82/8465 | 4.37e-03 | 4.10e-02 | 3.30e-02 | 19 |
hsa041464 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa041465 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa041466 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414611 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414621 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
hsa0414631 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PEX13 | SNV | Missense_Mutation | novel | c.374N>C | p.Ser125Thr | p.S125T | Q92968 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PEX13 | SNV | Missense_Mutation | c.1114N>A | p.Glu372Lys | p.E372K | Q92968 | protein_coding | tolerated(0.09) | benign(0.021) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PEX13 | SNV | Missense_Mutation | c.31N>T | p.Pro11Ser | p.P11S | Q92968 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PEX13 | SNV | Missense_Mutation | c.341N>G | p.Pro114Arg | p.P114R | Q92968 | protein_coding | tolerated(0.15) | probably_damaging(0.959) | TCGA-EW-A1IY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
PEX13 | insertion | Frame_Shift_Ins | novel | c.304_305insCTGTTATCCTGACATTTTGGGA | p.Gly102AlafsTer18 | p.G102Afs*18 | Q92968 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PEX13 | SNV | Missense_Mutation | c.635N>T | p.Ala212Val | p.A212V | Q92968 | protein_coding | tolerated(0.08) | benign(0.068) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PEX13 | SNV | Missense_Mutation | novel | c.206N>C | p.Asn69Thr | p.N69T | Q92968 | protein_coding | tolerated(0.24) | benign(0.079) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PEX13 | SNV | Missense_Mutation | c.41C>T | p.Thr14Ile | p.T14I | Q92968 | protein_coding | tolerated(0.12) | benign(0.063) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
PEX13 | SNV | Missense_Mutation | c.983N>T | p.Ala328Val | p.A328V | Q92968 | protein_coding | deleterious(0.02) | benign(0.209) | TCGA-AG-3591-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unspecific | Complete Response | ||
PEX13 | SNV | Missense_Mutation | novel | c.110N>A | p.Pro37His | p.P37H | Q92968 | protein_coding | deleterious(0.04) | possibly_damaging(0.628) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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