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Gene: PDK2 |
Gene summary for PDK2 |
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Gene information | Species | Human | Gene symbol | PDK2 | Gene ID | 5164 |
Gene name | pyruvate dehydrogenase kinase 2 | |
Gene Alias | PDHK2 | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | Q15119 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5164 | PDK2 | LZE4T | Human | Esophagus | ESCC | 3.86e-05 | 1.12e-01 | 0.0811 |
5164 | PDK2 | LZE7T | Human | Esophagus | ESCC | 2.14e-05 | 1.55e-01 | 0.0667 |
5164 | PDK2 | LZE20T | Human | Esophagus | ESCC | 4.57e-03 | 1.13e-01 | 0.0662 |
5164 | PDK2 | LZE21D1 | Human | Esophagus | HGIN | 7.58e-03 | 1.88e-01 | 0.0632 |
5164 | PDK2 | LZE22T | Human | Esophagus | ESCC | 3.42e-05 | 2.68e-01 | 0.068 |
5164 | PDK2 | LZE24T | Human | Esophagus | ESCC | 3.46e-16 | 5.16e-01 | 0.0596 |
5164 | PDK2 | LZE21T | Human | Esophagus | ESCC | 1.08e-04 | 3.26e-01 | 0.0655 |
5164 | PDK2 | LZE6T | Human | Esophagus | ESCC | 1.56e-05 | 2.71e-01 | 0.0845 |
5164 | PDK2 | P1T-E | Human | Esophagus | ESCC | 8.49e-12 | 3.59e-01 | 0.0875 |
5164 | PDK2 | P2T-E | Human | Esophagus | ESCC | 6.56e-32 | 4.81e-01 | 0.1177 |
5164 | PDK2 | P4T-E | Human | Esophagus | ESCC | 3.02e-21 | 5.10e-01 | 0.1323 |
5164 | PDK2 | P5T-E | Human | Esophagus | ESCC | 6.98e-16 | 2.03e-01 | 0.1327 |
5164 | PDK2 | P8T-E | Human | Esophagus | ESCC | 2.49e-24 | 3.78e-01 | 0.0889 |
5164 | PDK2 | P9T-E | Human | Esophagus | ESCC | 1.97e-10 | 1.81e-01 | 0.1131 |
5164 | PDK2 | P10T-E | Human | Esophagus | ESCC | 1.27e-34 | 5.18e-01 | 0.116 |
5164 | PDK2 | P11T-E | Human | Esophagus | ESCC | 6.64e-12 | 5.22e-01 | 0.1426 |
5164 | PDK2 | P12T-E | Human | Esophagus | ESCC | 1.09e-23 | 4.60e-01 | 0.1122 |
5164 | PDK2 | P15T-E | Human | Esophagus | ESCC | 1.16e-19 | 3.61e-01 | 0.1149 |
5164 | PDK2 | P16T-E | Human | Esophagus | ESCC | 2.55e-17 | 2.59e-01 | 0.1153 |
5164 | PDK2 | P17T-E | Human | Esophagus | ESCC | 2.33e-06 | 2.60e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00340304 | Esophagus | ESCC | ribonucleoside bisphosphate biosynthetic process | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:00340334 | Esophagus | ESCC | purine nucleoside bisphosphate biosynthetic process | 44/8552 | 60/18723 | 1.25e-05 | 1.15e-04 | 44 |
GO:00060069 | Esophagus | ESCC | glucose metabolic process | 119/8552 | 196/18723 | 1.51e-05 | 1.36e-04 | 119 |
GO:007252217 | Esophagus | ESCC | purine-containing compound biosynthetic process | 120/8552 | 200/18723 | 3.02e-05 | 2.51e-04 | 120 |
GO:00066318 | Esophagus | ESCC | fatty acid metabolic process | 217/8552 | 390/18723 | 4.21e-05 | 3.39e-04 | 217 |
GO:0009152110 | Esophagus | ESCC | purine ribonucleotide biosynthetic process | 103/8552 | 169/18723 | 4.40e-05 | 3.51e-04 | 103 |
GO:007137516 | Esophagus | ESCC | cellular response to peptide hormone stimulus | 166/8552 | 290/18723 | 4.48e-05 | 3.55e-04 | 166 |
GO:000616417 | Esophagus | ESCC | purine nucleotide biosynthetic process | 113/8552 | 191/18723 | 1.16e-04 | 8.04e-04 | 113 |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
GO:00620129 | Esophagus | ESCC | regulation of small molecule metabolic process | 184/8552 | 334/18723 | 3.11e-04 | 1.85e-03 | 184 |
GO:00353844 | Esophagus | ESCC | thioester biosynthetic process | 32/8552 | 45/18723 | 4.87e-04 | 2.70e-03 | 32 |
GO:00716164 | Esophagus | ESCC | acyl-CoA biosynthetic process | 32/8552 | 45/18723 | 4.87e-04 | 2.70e-03 | 32 |
GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
GO:00338655 | Esophagus | ESCC | nucleoside bisphosphate metabolic process | 77/8552 | 128/18723 | 6.71e-04 | 3.55e-03 | 77 |
GO:00338755 | Esophagus | ESCC | ribonucleoside bisphosphate metabolic process | 77/8552 | 128/18723 | 6.71e-04 | 3.55e-03 | 77 |
GO:00340325 | Esophagus | ESCC | purine nucleoside bisphosphate metabolic process | 77/8552 | 128/18723 | 6.71e-04 | 3.55e-03 | 77 |
GO:00463643 | Esophagus | ESCC | monosaccharide biosynthetic process | 52/8552 | 82/18723 | 9.03e-04 | 4.61e-03 | 52 |
GO:00060853 | Esophagus | ESCC | acetyl-CoA biosynthetic process | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
GO:00109065 | Esophagus | ESCC | regulation of glucose metabolic process | 71/8552 | 119/18723 | 1.46e-03 | 6.92e-03 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541530 | Esophagus | HGIN | Diabetic cardiomyopathy | 80/1383 | 203/8465 | 1.35e-15 | 3.38e-14 | 2.69e-14 | 80 |
hsa05415114 | Esophagus | HGIN | Diabetic cardiomyopathy | 80/1383 | 203/8465 | 1.35e-15 | 3.38e-14 | 2.69e-14 | 80 |
hsa05415211 | Esophagus | ESCC | Diabetic cardiomyopathy | 146/4205 | 203/8465 | 5.81e-11 | 7.78e-10 | 3.99e-10 | 146 |
hsa0541538 | Esophagus | ESCC | Diabetic cardiomyopathy | 146/4205 | 203/8465 | 5.81e-11 | 7.78e-10 | 3.99e-10 | 146 |
hsa0541522 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0541532 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0541529 | Oral cavity | OSCC | Diabetic cardiomyopathy | 131/3704 | 203/8465 | 1.33e-09 | 1.49e-08 | 7.57e-09 | 131 |
hsa05415113 | Oral cavity | OSCC | Diabetic cardiomyopathy | 131/3704 | 203/8465 | 1.33e-09 | 1.49e-08 | 7.57e-09 | 131 |
hsa05415210 | Oral cavity | LP | Diabetic cardiomyopathy | 106/2418 | 203/8465 | 6.51e-13 | 1.36e-11 | 8.74e-12 | 106 |
hsa0541537 | Oral cavity | LP | Diabetic cardiomyopathy | 106/2418 | 203/8465 | 6.51e-13 | 1.36e-11 | 8.74e-12 | 106 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDK2 | SNV | Missense_Mutation | novel | c.151N>C | p.Thr51Pro | p.T51P | Q15119 | protein_coding | tolerated(0.27) | benign(0.313) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
PDK2 | SNV | Missense_Mutation | novel | c.793N>A | p.Glu265Lys | p.E265K | Q15119 | protein_coding | tolerated(0.35) | benign(0.005) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
PDK2 | SNV | Missense_Mutation | c.897N>T | p.Lys299Asn | p.K299N | Q15119 | protein_coding | tolerated(0.07) | benign(0.265) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
PDK2 | SNV | Missense_Mutation | c.221G>A | p.Arg74Gln | p.R74Q | Q15119 | protein_coding | tolerated(0.4) | benign(0.01) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
PDK2 | SNV | Missense_Mutation | c.406N>A | p.Glu136Lys | p.E136K | Q15119 | protein_coding | deleterious(0.03) | possibly_damaging(0.725) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
PDK2 | insertion | Frame_Shift_Ins | novel | c.598_599insGACCTAGACCACTCTTCAGAACCCCACAAAGGGAGTC | p.Val200GlyfsTer22 | p.V200Gfs*22 | Q15119 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
PDK2 | SNV | Missense_Mutation | rs570482316 | c.962N>T | p.Thr321Met | p.T321M | Q15119 | protein_coding | deleterious(0) | possibly_damaging(0.85) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDK2 | SNV | Missense_Mutation | c.815N>T | p.Pro272Leu | p.P272L | Q15119 | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-EK-A2GZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
PDK2 | SNV | Missense_Mutation | rs752026536 | c.776N>T | p.Ala259Val | p.A259V | Q15119 | protein_coding | deleterious(0) | possibly_damaging(0.902) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDK2 | SNV | Missense_Mutation | c.832N>A | p.Ala278Thr | p.A278T | Q15119 | protein_coding | tolerated(0.92) | benign(0.006) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5164 | PDK2 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | inhibitor | 328083464 | ||
5164 | PDK2 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | CPI-613 | |||
5164 | PDK2 | ENZYME, KINASE, SERINE THREONINE KINASE, DRUGGABLE GENOME | inhibitor | 328083452 |
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