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Gene: PDHA1 |
Gene summary for PDHA1 |
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Gene information | Species | Human | Gene symbol | PDHA1 | Gene ID | 5160 |
Gene name | pyruvate dehydrogenase E1 subunit alpha 1 | |
Gene Alias | PDHA | |
Cytomap | Xp22.12 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A0A024RBX9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5160 | PDHA1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.92e-06 | 4.27e-01 | -0.1954 |
5160 | PDHA1 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.37e-05 | 5.83e-01 | -0.1526 |
5160 | PDHA1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.72e-07 | 6.02e-01 | -0.059 |
5160 | PDHA1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.70e-02 | 3.12e-01 | 0.096 |
5160 | PDHA1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.10e-13 | 5.50e-01 | 0.0674 |
5160 | PDHA1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.77e-06 | 4.93e-01 | 0.281 |
5160 | PDHA1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.06e-15 | 6.93e-01 | 0.3859 |
5160 | PDHA1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.18e-02 | 5.41e-01 | 0.2585 |
5160 | PDHA1 | A015-C-203 | Human | Colorectum | FAP | 1.27e-04 | -6.87e-02 | -0.1294 |
5160 | PDHA1 | A001-C-119 | Human | Colorectum | FAP | 2.20e-03 | -2.53e-01 | -0.1557 |
5160 | PDHA1 | A001-C-108 | Human | Colorectum | FAP | 6.65e-05 | -1.27e-01 | -0.0272 |
5160 | PDHA1 | A002-C-205 | Human | Colorectum | FAP | 2.09e-05 | -1.90e-01 | -0.1236 |
5160 | PDHA1 | A015-C-006 | Human | Colorectum | FAP | 4.03e-04 | -2.30e-01 | -0.0994 |
5160 | PDHA1 | A002-C-114 | Human | Colorectum | FAP | 2.66e-03 | -1.15e-01 | -0.1561 |
5160 | PDHA1 | A015-C-104 | Human | Colorectum | FAP | 1.32e-06 | -1.10e-01 | -0.1899 |
5160 | PDHA1 | A001-C-014 | Human | Colorectum | FAP | 3.59e-06 | -1.94e-01 | 0.0135 |
5160 | PDHA1 | A002-C-116 | Human | Colorectum | FAP | 7.41e-08 | -2.11e-01 | -0.0452 |
5160 | PDHA1 | A018-E-020 | Human | Colorectum | FAP | 6.16e-04 | -2.38e-02 | -0.2034 |
5160 | PDHA1 | F034 | Human | Colorectum | FAP | 2.84e-02 | -1.14e-01 | -0.0665 |
5160 | PDHA1 | F072B | Human | Colorectum | FAP | 8.37e-03 | -1.64e-01 | 0.257 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091172 | Colorectum | MSS | nucleotide metabolic process | 144/3467 | 489/18723 | 1.87e-09 | 1.35e-07 | 144 |
GO:00067532 | Colorectum | MSS | nucleoside phosphate metabolic process | 145/3467 | 497/18723 | 3.25e-09 | 2.23e-07 | 145 |
GO:00091522 | Colorectum | MSS | purine ribonucleotide biosynthetic process | 57/3467 | 169/18723 | 1.63e-06 | 5.32e-05 | 57 |
GO:00092602 | Colorectum | MSS | ribonucleotide biosynthetic process | 59/3467 | 182/18723 | 4.55e-06 | 1.27e-04 | 59 |
GO:00463902 | Colorectum | MSS | ribose phosphate biosynthetic process | 60/3467 | 190/18723 | 9.54e-06 | 2.33e-04 | 60 |
GO:00060992 | Colorectum | MSS | tricarboxylic acid cycle | 16/3467 | 30/18723 | 1.90e-05 | 4.12e-04 | 16 |
GO:00061642 | Colorectum | MSS | purine nucleotide biosynthetic process | 59/3467 | 191/18723 | 2.36e-05 | 4.97e-04 | 59 |
GO:00725222 | Colorectum | MSS | purine-containing compound biosynthetic process | 61/3467 | 200/18723 | 2.65e-05 | 5.46e-04 | 61 |
GO:00060902 | Colorectum | MSS | pyruvate metabolic process | 37/3467 | 106/18723 | 4.48e-05 | 8.28e-04 | 37 |
GO:19012932 | Colorectum | MSS | nucleoside phosphate biosynthetic process | 71/3467 | 256/18723 | 1.80e-04 | 2.56e-03 | 71 |
GO:00091652 | Colorectum | MSS | nucleotide biosynthetic process | 70/3467 | 254/18723 | 2.44e-04 | 3.34e-03 | 70 |
GO:00193182 | Colorectum | MSS | hexose metabolic process | 63/3467 | 237/18723 | 1.32e-03 | 1.25e-02 | 63 |
GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
GO:00059962 | Colorectum | MSS | monosaccharide metabolic process | 66/3467 | 257/18723 | 2.61e-03 | 2.06e-02 | 66 |
GO:00060062 | Colorectum | MSS | glucose metabolic process | 51/3467 | 196/18723 | 5.67e-03 | 3.85e-02 | 51 |
GO:00060914 | Colorectum | FAP | generation of precursor metabolites and energy | 128/2622 | 490/18723 | 5.58e-13 | 4.28e-10 | 128 |
GO:00091504 | Colorectum | FAP | purine ribonucleotide metabolic process | 96/2622 | 368/18723 | 4.91e-10 | 1.20e-07 | 96 |
GO:00159804 | Colorectum | FAP | energy derivation by oxidation of organic compounds | 85/2622 | 318/18723 | 1.36e-09 | 2.77e-07 | 85 |
GO:00061634 | Colorectum | FAP | purine nucleotide metabolic process | 100/2622 | 396/18723 | 1.45e-09 | 2.77e-07 | 100 |
GO:00092593 | Colorectum | FAP | ribonucleotide metabolic process | 97/2622 | 385/18723 | 2.90e-09 | 5.07e-07 | 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00620 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa00020 | Colorectum | AD | Citrate cycle (TCA cycle) | 20/2092 | 30/8465 | 1.43e-06 | 1.77e-05 | 1.13e-05 | 20 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa05230 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa006201 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa000201 | Colorectum | AD | Citrate cycle (TCA cycle) | 20/2092 | 30/8465 | 1.43e-06 | 1.77e-05 | 1.13e-05 | 20 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa040661 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa052301 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa054152 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa006202 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa000202 | Colorectum | SER | Citrate cycle (TCA cycle) | 16/1580 | 30/8465 | 2.06e-05 | 2.74e-04 | 1.99e-04 | 16 |
hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa012002 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
hsa040662 | Colorectum | SER | HIF-1 signaling pathway | 36/1580 | 109/8465 | 2.27e-04 | 2.15e-03 | 1.56e-03 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDHA1 | SNV | Missense_Mutation | c.904N>A | p.Glu302Lys | p.E302K | P08559 | protein_coding | deleterious(0.04) | probably_damaging(0.928) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
PDHA1 | SNV | Missense_Mutation | c.914N>A | p.Arg305Lys | p.R305K | P08559 | protein_coding | tolerated(1) | benign(0.001) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
PDHA1 | insertion | Frame_Shift_Ins | novel | c.807_808insGCAAAACAATACAGACCCAT | p.Ser270AlafsTer28 | p.S270Afs*28 | P08559 | protein_coding | TCGA-AN-A0FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PDHA1 | insertion | Frame_Shift_Ins | novel | c.282_283insTTTAAAAATTATTTTAGAATTAAAA | p.Thr95PhefsTer35 | p.T95Ffs*35 | P08559 | protein_coding | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
PDHA1 | SNV | Missense_Mutation | novel | c.215N>T | p.Ala72Val | p.A72V | P08559 | protein_coding | tolerated(0.08) | benign(0.103) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDHA1 | SNV | Missense_Mutation | rs144967854 | c.248N>A | p.Arg83Gln | p.R83Q | P08559 | protein_coding | tolerated(0.15) | benign(0.063) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDHA1 | SNV | Missense_Mutation | novel | c.371N>G | p.Ile124Ser | p.I124S | P08559 | protein_coding | tolerated(0.17) | benign(0.083) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDHA1 | SNV | Missense_Mutation | c.707N>A | p.Ala236Asp | p.A236D | P08559 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
PDHA1 | SNV | Missense_Mutation | novel | c.700N>C | p.Asp234His | p.D234H | P08559 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
PDHA1 | SNV | Missense_Mutation | rs794729213 | c.536N>A | p.Arg179Gln | p.R179Q | P08559 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5160 | PDHA1 | ENZYME | CPI-613 |
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