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Gene: PDE7B |
Gene summary for PDE7B |
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Gene information | Species | Human | Gene symbol | PDE7B | Gene ID | 27115 |
Gene name | phosphodiesterase 7B | |
Gene Alias | bA472E5.1 | |
Cytomap | 6q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NP56 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27115 | PDE7B | NAFLD1 | Human | Liver | NAFLD | 5.34e-12 | 1.22e+00 | -0.04 |
27115 | PDE7B | S43 | Human | Liver | Cirrhotic | 9.71e-03 | -1.41e-01 | -0.0187 |
27115 | PDE7B | HCC1_Meng | Human | Liver | HCC | 1.12e-05 | -2.05e-01 | 0.0246 |
27115 | PDE7B | HCC2_Meng | Human | Liver | HCC | 4.13e-04 | -1.98e-01 | 0.0107 |
27115 | PDE7B | HCC2 | Human | Liver | HCC | 7.32e-06 | 8.75e-01 | 0.5341 |
27115 | PDE7B | Pt13.a | Human | Liver | HCC | 2.64e-03 | -1.88e-01 | 0.021 |
27115 | PDE7B | Pt14.d | Human | Liver | HCC | 1.30e-03 | -1.90e-01 | 0.0143 |
27115 | PDE7B | HTA12-26-1 | Human | Pancreas | PDAC | 9.79e-17 | 8.21e-01 | 0.3728 |
27115 | PDE7B | HTA12-29-1 | Human | Pancreas | PDAC | 1.40e-31 | 7.14e-01 | 0.3722 |
27115 | PDE7B | HTA12-30-1 | Human | Pancreas | PDAC | 1.14e-02 | 9.19e-01 | 0.3671 |
27115 | PDE7B | PTC07 | Human | Thyroid | PTC | 1.45e-07 | 4.32e-02 | 0.2044 |
27115 | PDE7B | ATC12 | Human | Thyroid | ATC | 8.48e-15 | 3.11e-01 | 0.34 |
27115 | PDE7B | ATC13 | Human | Thyroid | ATC | 1.61e-39 | 6.45e-01 | 0.34 |
27115 | PDE7B | ATC4 | Human | Thyroid | ATC | 1.23e-16 | 3.48e-01 | 0.34 |
27115 | PDE7B | ATC5 | Human | Thyroid | ATC | 8.04e-38 | 6.86e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001943924 | Thyroid | ATC | aromatic compound catabolic process | 232/6293 | 467/18723 | 3.05e-13 | 1.44e-11 | 232 |
GO:190136124 | Thyroid | ATC | organic cyclic compound catabolic process | 238/6293 | 495/18723 | 1.12e-11 | 4.12e-10 | 238 |
GO:001969328 | Thyroid | ATC | ribose phosphate metabolic process | 184/6293 | 396/18723 | 5.87e-08 | 1.05e-06 | 184 |
GO:000915029 | Thyroid | ATC | purine ribonucleotide metabolic process | 172/6293 | 368/18723 | 9.58e-08 | 1.64e-06 | 172 |
GO:000925928 | Thyroid | ATC | ribonucleotide metabolic process | 178/6293 | 385/18723 | 1.47e-07 | 2.39e-06 | 178 |
GO:007252128 | Thyroid | ATC | purine-containing compound metabolic process | 189/6293 | 416/18723 | 2.83e-07 | 4.29e-06 | 189 |
GO:0006753111 | Thyroid | ATC | nucleoside phosphate metabolic process | 219/6293 | 497/18723 | 5.92e-07 | 8.29e-06 | 219 |
GO:0009117112 | Thyroid | ATC | nucleotide metabolic process | 215/6293 | 489/18723 | 9.09e-07 | 1.20e-05 | 215 |
GO:000616328 | Thyroid | ATC | purine nucleotide metabolic process | 177/6293 | 396/18723 | 2.39e-06 | 2.82e-05 | 177 |
GO:19011363 | Thyroid | ATC | carbohydrate derivative catabolic process | 73/6293 | 172/18723 | 9.43e-03 | 3.47e-02 | 73 |
GO:00725232 | Thyroid | ATC | purine-containing compound catabolic process | 26/6293 | 52/18723 | 1.05e-02 | 3.82e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE7B | SNV | Missense_Mutation | c.1229N>T | p.Lys410Met | p.K410M | Q9NP56 | protein_coding | deleterious(0.01) | probably_damaging(0.96) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
PDE7B | SNV | Missense_Mutation | rs377744382 | c.52G>A | p.Asp18Asn | p.D18N | Q9NP56 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.517) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDE7B | SNV | Missense_Mutation | c.601N>G | p.Leu201Val | p.L201V | Q9NP56 | protein_coding | tolerated(0.21) | possibly_damaging(0.497) | TCGA-JW-A5VJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
PDE7B | SNV | Missense_Mutation | c.253N>T | p.Leu85Phe | p.L85F | Q9NP56 | protein_coding | tolerated(0.57) | benign(0.014) | TCGA-AA-3844-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
PDE7B | SNV | Missense_Mutation | novel | c.149N>G | p.Asp50Gly | p.D50G | Q9NP56 | protein_coding | deleterious(0.01) | possibly_damaging(0.493) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDE7B | SNV | Missense_Mutation | rs574015160 | c.31G>A | p.Glu11Lys | p.E11K | Q9NP56 | protein_coding | tolerated_low_confidence(0.09) | benign(0.054) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PDE7B | SNV | Missense_Mutation | c.424C>T | p.His142Tyr | p.H142Y | Q9NP56 | protein_coding | tolerated(0.76) | benign(0.015) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
PDE7B | SNV | Missense_Mutation | c.283C>T | p.His95Tyr | p.H95Y | Q9NP56 | protein_coding | tolerated(0.42) | benign(0.005) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDE7B | SNV | Missense_Mutation | rs201422143 | c.1219N>A | p.Ala407Thr | p.A407T | Q9NP56 | protein_coding | tolerated(0.55) | benign(0.005) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDE7B | SNV | Missense_Mutation | c.85N>C | p.Asp29His | p.D29H | Q9NP56 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.928) | TCGA-AF-3913-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
27115 | PDE7B | DRUGGABLE GENOME, ENZYME | DYPHYLLINE | DYPHYLLINE | ||
27115 | PDE7B | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL628 | PENTOXIFYLLINE | |
27115 | PDE7B | DRUGGABLE GENOME, ENZYME | DYPHYLLINE | DYPHYLLINE | ||
27115 | PDE7B | DRUGGABLE GENOME, ENZYME | inhibitor | 178101846 | ||
27115 | PDE7B | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL932 | DIPYRIDAMOLE | |
27115 | PDE7B | DRUGGABLE GENOME, ENZYME | inhibitor | 178101953 | ||
27115 | PDE7B | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL1200875 | FLAVOXATE HYDROCHLORIDE | |
27115 | PDE7B | DRUGGABLE GENOME, ENZYME | inhibitor | 178101509 | DIPYRIDAMOLE |
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