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Gene: PACSIN3 |
Gene summary for PACSIN3 |
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Gene information | Species | Human | Gene symbol | PACSIN3 | Gene ID | 29763 |
Gene name | protein kinase C and casein kinase substrate in neurons 3 | |
Gene Alias | SDPIII | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9UKS6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29763 | PACSIN3 | LZE4T | Human | Esophagus | ESCC | 1.12e-02 | 9.31e-02 | 0.0811 |
29763 | PACSIN3 | LZE7T | Human | Esophagus | ESCC | 6.51e-03 | 2.51e-01 | 0.0667 |
29763 | PACSIN3 | LZE8T | Human | Esophagus | ESCC | 6.63e-04 | 4.49e-02 | 0.067 |
29763 | PACSIN3 | LZE22T | Human | Esophagus | ESCC | 2.79e-02 | 1.81e-01 | 0.068 |
29763 | PACSIN3 | LZE24T | Human | Esophagus | ESCC | 6.28e-09 | 3.45e-01 | 0.0596 |
29763 | PACSIN3 | P1T-E | Human | Esophagus | ESCC | 1.97e-04 | 4.41e-01 | 0.0875 |
29763 | PACSIN3 | P2T-E | Human | Esophagus | ESCC | 1.41e-22 | 5.46e-01 | 0.1177 |
29763 | PACSIN3 | P4T-E | Human | Esophagus | ESCC | 2.83e-23 | 5.00e-01 | 0.1323 |
29763 | PACSIN3 | P5T-E | Human | Esophagus | ESCC | 4.39e-17 | 2.60e-01 | 0.1327 |
29763 | PACSIN3 | P8T-E | Human | Esophagus | ESCC | 2.57e-22 | 3.84e-01 | 0.0889 |
29763 | PACSIN3 | P9T-E | Human | Esophagus | ESCC | 4.09e-15 | 4.58e-01 | 0.1131 |
29763 | PACSIN3 | P10T-E | Human | Esophagus | ESCC | 3.89e-13 | 1.04e-01 | 0.116 |
29763 | PACSIN3 | P11T-E | Human | Esophagus | ESCC | 3.49e-14 | 6.27e-01 | 0.1426 |
29763 | PACSIN3 | P12T-E | Human | Esophagus | ESCC | 7.62e-20 | 3.95e-01 | 0.1122 |
29763 | PACSIN3 | P15T-E | Human | Esophagus | ESCC | 2.38e-17 | 4.13e-01 | 0.1149 |
29763 | PACSIN3 | P16T-E | Human | Esophagus | ESCC | 7.82e-24 | 3.74e-01 | 0.1153 |
29763 | PACSIN3 | P17T-E | Human | Esophagus | ESCC | 7.98e-15 | 5.69e-01 | 0.1278 |
29763 | PACSIN3 | P19T-E | Human | Esophagus | ESCC | 1.00e-04 | 6.91e-01 | 0.1662 |
29763 | PACSIN3 | P20T-E | Human | Esophagus | ESCC | 3.77e-19 | 4.52e-01 | 0.1124 |
29763 | PACSIN3 | P21T-E | Human | Esophagus | ESCC | 2.02e-36 | 7.97e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510518 | Thyroid | PTC | negative regulation of transport | 176/5968 | 470/18723 | 5.44e-03 | 2.49e-02 | 176 |
GO:0009896210 | Thyroid | ATC | positive regulation of catabolic process | 290/6293 | 492/18723 | 2.15e-31 | 1.94e-28 | 290 |
GO:0031331210 | Thyroid | ATC | positive regulation of cellular catabolic process | 258/6293 | 427/18723 | 2.09e-30 | 1.65e-27 | 258 |
GO:004217635 | Thyroid | ATC | regulation of protein catabolic process | 239/6293 | 391/18723 | 2.63e-29 | 1.85e-26 | 239 |
GO:0045732210 | Thyroid | ATC | positive regulation of protein catabolic process | 148/6293 | 231/18723 | 1.93e-21 | 4.36e-19 | 148 |
GO:004586234 | Thyroid | ATC | positive regulation of proteolysis | 202/6293 | 372/18723 | 1.07e-16 | 9.42e-15 | 202 |
GO:0030100111 | Thyroid | ATC | regulation of endocytosis | 113/6293 | 211/18723 | 1.71e-09 | 4.22e-08 | 113 |
GO:003361914 | Thyroid | ATC | membrane protein proteolysis | 35/6293 | 57/18723 | 1.58e-05 | 1.46e-04 | 35 |
GO:000650922 | Thyroid | ATC | membrane protein ectodomain proteolysis | 27/6293 | 43/18723 | 8.44e-05 | 6.30e-04 | 27 |
GO:009732011 | Thyroid | ATC | plasma membrane tubulation | 13/6293 | 20/18723 | 4.03e-03 | 1.73e-02 | 13 |
GO:005105114 | Thyroid | ATC | negative regulation of transport | 183/6293 | 470/18723 | 8.12e-03 | 3.13e-02 | 183 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PACSIN3 | SNV | Missense_Mutation | c.663N>T | p.Met221Ile | p.M221I | Q9UKS6 | protein_coding | tolerated(0.15) | possibly_damaging(0.677) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
PACSIN3 | SNV | Missense_Mutation | c.634N>A | p.Glu212Lys | p.E212K | Q9UKS6 | protein_coding | deleterious(0) | benign(0.341) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
PACSIN3 | SNV | Missense_Mutation | rs763827628 | c.71G>A | p.Arg24His | p.R24H | Q9UKS6 | protein_coding | deleterious(0.01) | possibly_damaging(0.494) | TCGA-D8-A1XY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | tamoxiphen | SD |
PACSIN3 | SNV | Missense_Mutation | novel | c.839N>G | p.Asp280Gly | p.D280G | Q9UKS6 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-GM-A5PV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
PACSIN3 | SNV | Missense_Mutation | c.901G>A | p.Glu301Lys | p.E301K | Q9UKS6 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-JW-A5VJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
PACSIN3 | SNV | Missense_Mutation | novel | c.1179G>C | p.Met393Ile | p.M393I | Q9UKS6 | protein_coding | tolerated(0.62) | benign(0.003) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PACSIN3 | SNV | Missense_Mutation | c.1229G>A | p.Arg410His | p.R410H | Q9UKS6 | protein_coding | tolerated(0.06) | benign(0.013) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PACSIN3 | SNV | Missense_Mutation | rs199499148 | c.139N>A | p.Ala47Thr | p.A47T | Q9UKS6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PACSIN3 | SNV | Missense_Mutation | c.1103T>C | p.Val368Ala | p.V368A | Q9UKS6 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
PACSIN3 | SNV | Missense_Mutation | c.1229N>A | p.Arg410His | p.R410H | Q9UKS6 | protein_coding | tolerated(0.06) | benign(0.013) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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