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Gene: NUP50 |
Gene summary for NUP50 |
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Gene information | Species | Human | Gene symbol | NUP50 | Gene ID | 10762 |
Gene name | nucleoporin 50 | |
Gene Alias | NPAP60 | |
Cytomap | 22q13.31 | |
Gene Type | protein-coding | GO ID | GO:0006403 | UniProtAcc | A0A024R4X7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10762 | NUP50 | LZE4T | Human | Esophagus | ESCC | 1.06e-12 | 1.92e-01 | 0.0811 |
10762 | NUP50 | LZE7T | Human | Esophagus | ESCC | 3.71e-10 | 7.98e-01 | 0.0667 |
10762 | NUP50 | LZE8T | Human | Esophagus | ESCC | 9.18e-09 | 6.30e-02 | 0.067 |
10762 | NUP50 | LZE21D1 | Human | Esophagus | HGIN | 9.91e-03 | 5.22e-03 | 0.0632 |
10762 | NUP50 | LZE22D1 | Human | Esophagus | HGIN | 4.52e-02 | 3.28e-02 | 0.0595 |
10762 | NUP50 | LZE24T | Human | Esophagus | ESCC | 2.37e-13 | 3.96e-01 | 0.0596 |
10762 | NUP50 | LZE21T | Human | Esophagus | ESCC | 2.17e-06 | 6.91e-01 | 0.0655 |
10762 | NUP50 | LZE6T | Human | Esophagus | ESCC | 4.20e-04 | -1.90e-02 | 0.0845 |
10762 | NUP50 | P1T-E | Human | Esophagus | ESCC | 2.40e-10 | 2.56e-01 | 0.0875 |
10762 | NUP50 | P2T-E | Human | Esophagus | ESCC | 5.00e-16 | 3.06e-01 | 0.1177 |
10762 | NUP50 | P4T-E | Human | Esophagus | ESCC | 4.92e-17 | 4.26e-01 | 0.1323 |
10762 | NUP50 | P5T-E | Human | Esophagus | ESCC | 2.08e-11 | 4.12e-02 | 0.1327 |
10762 | NUP50 | P8T-E | Human | Esophagus | ESCC | 7.65e-14 | 2.71e-01 | 0.0889 |
10762 | NUP50 | P9T-E | Human | Esophagus | ESCC | 3.68e-34 | 9.63e-01 | 0.1131 |
10762 | NUP50 | P10T-E | Human | Esophagus | ESCC | 1.23e-23 | 4.99e-01 | 0.116 |
10762 | NUP50 | P11T-E | Human | Esophagus | ESCC | 1.93e-08 | 5.14e-01 | 0.1426 |
10762 | NUP50 | P12T-E | Human | Esophagus | ESCC | 1.34e-27 | 7.10e-01 | 0.1122 |
10762 | NUP50 | P15T-E | Human | Esophagus | ESCC | 2.28e-25 | 7.15e-01 | 0.1149 |
10762 | NUP50 | P16T-E | Human | Esophagus | ESCC | 5.57e-17 | 3.69e-01 | 0.1153 |
10762 | NUP50 | P20T-E | Human | Esophagus | ESCC | 1.19e-08 | 1.02e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005123615 | Oral cavity | LP | establishment of RNA localization | 79/4623 | 166/18723 | 1.18e-10 | 6.81e-09 | 79 |
GO:001593115 | Oral cavity | LP | nucleobase-containing compound transport | 95/4623 | 222/18723 | 2.23e-09 | 9.98e-08 | 95 |
GO:005102814 | Oral cavity | LP | mRNA transport | 62/4623 | 130/18723 | 1.03e-08 | 3.90e-07 | 62 |
GO:005117013 | Oral cavity | LP | import into nucleus | 65/4623 | 159/18723 | 4.78e-06 | 9.69e-05 | 65 |
GO:000660612 | Oral cavity | LP | protein import into nucleus | 62/4623 | 155/18723 | 1.76e-05 | 3.04e-04 | 62 |
GO:007259427 | Skin | cSCC | establishment of protein localization to organelle | 213/4864 | 422/18723 | 1.40e-27 | 5.15e-25 | 213 |
GO:000691324 | Skin | cSCC | nucleocytoplasmic transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:005116924 | Skin | cSCC | nuclear transport | 162/4864 | 301/18723 | 4.20e-25 | 1.10e-22 | 162 |
GO:0006403111 | Skin | cSCC | RNA localization | 120/4864 | 201/18723 | 4.17e-24 | 1.01e-21 | 120 |
GO:0034504110 | Skin | cSCC | protein localization to nucleus | 143/4864 | 290/18723 | 8.98e-18 | 1.02e-15 | 143 |
GO:005065719 | Skin | cSCC | nucleic acid transport | 92/4864 | 163/18723 | 1.35e-16 | 1.33e-14 | 92 |
GO:005065819 | Skin | cSCC | RNA transport | 92/4864 | 163/18723 | 1.35e-16 | 1.33e-14 | 92 |
GO:005123619 | Skin | cSCC | establishment of RNA localization | 93/4864 | 166/18723 | 1.78e-16 | 1.69e-14 | 93 |
GO:005102816 | Skin | cSCC | mRNA transport | 77/4864 | 130/18723 | 1.06e-15 | 8.95e-14 | 77 |
GO:0017038110 | Skin | cSCC | protein import | 100/4864 | 206/18723 | 2.50e-12 | 1.36e-10 | 100 |
GO:001593119 | Skin | cSCC | nucleobase-containing compound transport | 105/4864 | 222/18723 | 5.49e-12 | 2.89e-10 | 105 |
GO:005117016 | Skin | cSCC | import into nucleus | 77/4864 | 159/18723 | 9.17e-10 | 3.58e-08 | 77 |
GO:000660615 | Skin | cSCC | protein import into nucleus | 73/4864 | 155/18723 | 1.13e-08 | 3.48e-07 | 73 |
GO:007259428 | Thyroid | HT | establishment of protein localization to organelle | 60/1272 | 422/18723 | 4.06e-08 | 2.69e-06 | 60 |
GO:000640325 | Thyroid | HT | RNA localization | 35/1272 | 201/18723 | 2.37e-07 | 1.19e-05 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501430 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa030137 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa05014113 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa0301312 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa0501429 | Oral cavity | LP | Amyotrophic lateral sclerosis | 197/2418 | 364/8465 | 1.25e-25 | 1.39e-23 | 8.93e-24 | 197 |
hsa030132 | Oral cavity | LP | Nucleocytoplasmic transport | 53/2418 | 108/8465 | 4.68e-06 | 4.10e-05 | 2.64e-05 | 53 |
hsa0501437 | Oral cavity | LP | Amyotrophic lateral sclerosis | 197/2418 | 364/8465 | 1.25e-25 | 1.39e-23 | 8.93e-24 | 197 |
hsa030133 | Oral cavity | LP | Nucleocytoplasmic transport | 53/2418 | 108/8465 | 4.68e-06 | 4.10e-05 | 2.64e-05 | 53 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUP50 | SNV | Missense_Mutation | c.116N>T | p.Ala39Val | p.A39V | Q9UKX7 | protein_coding | tolerated(0.14) | possibly_damaging(0.881) | TCGA-E9-A1NE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
NUP50 | SNV | Missense_Mutation | rs144107829 | c.604N>A | p.Gly202Arg | p.G202R | Q9UKX7 | protein_coding | deleterious(0.04) | benign(0.308) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NUP50 | SNV | Missense_Mutation | novel | c.1135G>T | p.Gly379Cys | p.G379C | Q9UKX7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NUP50 | SNV | Missense_Mutation | rs201334547 | c.1343G>A | p.Arg448Gln | p.R448Q | Q9UKX7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUP50 | SNV | Missense_Mutation | rs371473562 | c.433N>T | p.Leu145Phe | p.L145F | Q9UKX7 | protein_coding | tolerated(0.58) | benign(0) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
NUP50 | SNV | Missense_Mutation | c.1267A>G | p.Asn423Asp | p.N423D | Q9UKX7 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-CA-5254-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
NUP50 | SNV | Missense_Mutation | c.494N>A | p.Cys165Tyr | p.C165Y | Q9UKX7 | protein_coding | tolerated(0.07) | probably_damaging(0.997) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NUP50 | SNV | Missense_Mutation | c.320N>T | p.Ala107Val | p.A107V | Q9UKX7 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NUP50 | SNV | Missense_Mutation | novel | c.139A>C | p.Asn47His | p.N47H | Q9UKX7 | protein_coding | tolerated(0.09) | benign(0.063) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NUP50 | SNV | Missense_Mutation | novel | c.523G>A | p.Val175Met | p.V175M | Q9UKX7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10762 | NUP50 | NA | teniposide | TENIPOSIDE | 24444404 |
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