|
Gene: NTS |
Gene summary for NTS |
Gene summary. |
Gene information | Species | Human | Gene symbol | NTS | Gene ID | 4922 |
Gene name | neurotensin | |
Gene Alias | NMN-125 | |
Cytomap | 12q21.31 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | P30990 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4922 | NTS | LZE11D | Human | Esophagus | HGIN | 9.56e-18 | 1.57e+00 | -0.005 |
4922 | NTS | LZE2T | Human | Esophagus | ESCC | 2.05e-21 | 3.54e+00 | 0.082 |
4922 | NTS | LZE4T | Human | Esophagus | ESCC | 1.39e-37 | 2.43e+00 | 0.0811 |
4922 | NTS | LZE21T | Human | Esophagus | ESCC | 2.35e-14 | 2.43e+00 | 0.0655 |
4922 | NTS | LZE6T | Human | Esophagus | ESCC | 1.87e-12 | 8.37e-01 | 0.0845 |
4922 | NTS | P1T-E | Human | Esophagus | ESCC | 4.53e-14 | 1.36e+00 | 0.0875 |
4922 | NTS | P4T-E | Human | Esophagus | ESCC | 5.27e-63 | 4.84e+00 | 0.1323 |
4922 | NTS | P8T-E | Human | Esophagus | ESCC | 2.87e-02 | 5.80e-01 | 0.0889 |
4922 | NTS | P9T-E | Human | Esophagus | ESCC | 3.22e-13 | 7.68e-01 | 0.1131 |
4922 | NTS | P10T-E | Human | Esophagus | ESCC | 7.79e-34 | 1.28e+00 | 0.116 |
4922 | NTS | P12T-E | Human | Esophagus | ESCC | 3.20e-82 | 3.48e+00 | 0.1122 |
4922 | NTS | P20T-E | Human | Esophagus | ESCC | 2.86e-10 | 9.31e-01 | 0.1124 |
4922 | NTS | P23T-E | Human | Esophagus | ESCC | 7.68e-77 | 4.68e+00 | 0.108 |
4922 | NTS | P26T-E | Human | Esophagus | ESCC | 1.29e-139 | 4.76e+00 | 0.1276 |
4922 | NTS | P27T-E | Human | Esophagus | ESCC | 7.14e-99 | 4.60e+00 | 0.1055 |
4922 | NTS | P28T-E | Human | Esophagus | ESCC | 2.33e-39 | 2.29e+00 | 0.1149 |
4922 | NTS | P30T-E | Human | Esophagus | ESCC | 2.31e-10 | 1.93e+00 | 0.137 |
4922 | NTS | P36T-E | Human | Esophagus | ESCC | 2.98e-06 | 8.40e-01 | 0.1187 |
4922 | NTS | P39T-E | Human | Esophagus | ESCC | 1.04e-13 | 1.39e+00 | 0.0894 |
4922 | NTS | P40T-E | Human | Esophagus | ESCC | 3.18e-05 | 1.48e+00 | 0.109 |
Page: 1 2 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007093 | Liver | HCC | mitotic cell cycle checkpoint | 77/7958 | 129/18723 | 6.00e-05 | 5.50e-04 | 77 |
GO:007147921 | Liver | HCC | cellular response to ionizing radiation | 47/7958 | 72/18723 | 7.95e-05 | 7.07e-04 | 47 |
GO:0090502 | Liver | HCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 52/7958 | 82/18723 | 1.06e-04 | 9.08e-04 | 52 |
GO:00714782 | Liver | HCC | cellular response to radiation | 104/7958 | 186/18723 | 1.48e-04 | 1.19e-03 | 104 |
GO:00000771 | Liver | HCC | DNA damage checkpoint | 68/7958 | 115/18723 | 2.33e-04 | 1.77e-03 | 68 |
GO:0031570 | Liver | HCC | DNA integrity checkpoint | 71/7958 | 123/18723 | 4.64e-04 | 3.08e-03 | 71 |
GO:1901988 | Liver | HCC | negative regulation of cell cycle phase transition | 132/7958 | 249/18723 | 4.97e-04 | 3.25e-03 | 132 |
GO:0010948 | Liver | HCC | negative regulation of cell cycle process | 152/7958 | 294/18723 | 8.50e-04 | 5.08e-03 | 152 |
GO:1901991 | Liver | HCC | negative regulation of mitotic cell cycle phase transition | 97/7958 | 179/18723 | 1.03e-03 | 5.91e-03 | 97 |
GO:0000086 | Liver | HCC | G2/M transition of mitotic cell cycle | 75/7958 | 137/18723 | 2.52e-03 | 1.22e-02 | 75 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
GO:0044839 | Liver | HCC | cell cycle G2/M phase transition | 79/7958 | 148/18723 | 4.82e-03 | 2.03e-02 | 79 |
GO:00344703 | Liver | Cyst | ncRNA processing | 25/496 | 395/18723 | 5.78e-05 | 3.01e-03 | 25 |
GO:00346602 | Liver | Cyst | ncRNA metabolic process | 28/496 | 485/18723 | 1.05e-04 | 4.67e-03 | 28 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:00447728 | Oral cavity | OSCC | mitotic cell cycle phase transition | 255/7305 | 424/18723 | 5.29e-19 | 6.98e-17 | 255 |
GO:00073469 | Oral cavity | OSCC | regulation of mitotic cell cycle | 266/7305 | 457/18723 | 3.87e-17 | 3.41e-15 | 266 |
GO:00102128 | Oral cavity | OSCC | response to ionizing radiation | 99/7305 | 148/18723 | 5.49e-12 | 2.08e-10 | 99 |
GO:19019905 | Oral cavity | OSCC | regulation of mitotic cell cycle phase transition | 173/7305 | 299/18723 | 2.49e-11 | 8.35e-10 | 173 |
Page: 1 2 3 4 5 6 7 8 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NTS | SNV | Missense_Mutation | c.494N>T | p.Arg165Ile | p.R165I | P30990 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
NTS | SNV | Missense_Mutation | c.462N>T | p.Glu154Asp | p.E154D | P30990 | protein_coding | tolerated(0.61) | benign(0.003) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NTS | SNV | Missense_Mutation | novel | c.496N>T | p.Asp166Tyr | p.D166Y | P30990 | protein_coding | deleterious(0.02) | benign(0.357) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NTS | SNV | Missense_Mutation | c.494N>T | p.Arg165Ile | p.R165I | P30990 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NTS | SNV | Missense_Mutation | novel | c.505T>C | p.Tyr169His | p.Y169H | P30990 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NTS | SNV | Missense_Mutation | novel | c.135N>T | p.Lys45Asn | p.K45N | P30990 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NTS | SNV | Missense_Mutation | c.280G>T | p.Asp94Tyr | p.D94Y | P30990 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NTS | SNV | Missense_Mutation | c.188N>T | p.Ser63Ile | p.S63I | P30990 | protein_coding | tolerated(0.14) | possibly_damaging(0.837) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NTS | SNV | Missense_Mutation | c.494N>T | p.Arg165Ile | p.R165I | P30990 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NTS | SNV | Missense_Mutation | c.425G>T | p.Arg142Ile | p.R142I | P30990 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4922 | NTS | DRUGGABLE GENOME | NORETHISTERONE | NORETHINDRONE | 11495683 | |
4922 | NTS | DRUGGABLE GENOME | MAGNESIUM SULFATE | 1758237 | ||
4922 | NTS | DRUGGABLE GENOME | LITHIUM | LITHIUM | 7992199 | |
4922 | NTS | DRUGGABLE GENOME | NIFEDIPINE | NIFEDIPINE | 8770786 | |
4922 | NTS | DRUGGABLE GENOME | haloperidol | HALOPERIDOL | 27023437 | |
4922 | NTS | DRUGGABLE GENOME | RISPERIDONE | RISPERIDONE | 10991962 | |
4922 | NTS | DRUGGABLE GENOME | CHLORPROMAZINE | CHLORPROMAZINE | 1980851 | |
4922 | NTS | DRUGGABLE GENOME | ETHANOL | ALCOHOL | 9023306,1733422,1686369 | |
4922 | NTS | DRUGGABLE GENOME | AZASERINE | AZASERINE | 1993548 |
Page: 1 |