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Gene: NTM |
Gene summary for NTM |
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Gene information | Species | Human | Gene symbol | NTM | Gene ID | 50863 |
Gene name | neurotrimin | |
Gene Alias | CEPU-1 | |
Cytomap | 11q25 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | Q9P121 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50863 | NTM | P4T-E | Human | Esophagus | ESCC | 7.93e-07 | 2.98e-01 | 0.1323 |
50863 | NTM | P9T-E | Human | Esophagus | ESCC | 4.01e-04 | 2.41e-01 | 0.1131 |
50863 | NTM | P11T-E | Human | Esophagus | ESCC | 1.92e-17 | 1.19e+00 | 0.1426 |
50863 | NTM | P16T-E | Human | Esophagus | ESCC | 2.53e-03 | 6.31e-02 | 0.1153 |
50863 | NTM | P19T-E | Human | Esophagus | ESCC | 1.17e-11 | 1.65e+00 | 0.1662 |
50863 | NTM | P24T-E | Human | Esophagus | ESCC | 9.20e-06 | 3.08e-01 | 0.1287 |
50863 | NTM | P30T-E | Human | Esophagus | ESCC | 4.84e-02 | 2.03e-01 | 0.137 |
50863 | NTM | P32T-E | Human | Esophagus | ESCC | 4.30e-10 | 4.37e-01 | 0.1666 |
50863 | NTM | P42T-E | Human | Esophagus | ESCC | 2.79e-04 | 2.38e-01 | 0.1175 |
50863 | NTM | P44T-E | Human | Esophagus | ESCC | 1.46e-07 | 3.83e-01 | 0.1096 |
50863 | NTM | P47T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.19e-01 | 0.1067 |
50863 | NTM | P56T-E | Human | Esophagus | ESCC | 1.16e-08 | 9.05e-01 | 0.1613 |
50863 | NTM | P89T-E | Human | Esophagus | ESCC | 1.41e-38 | 1.70e+00 | 0.1752 |
50863 | NTM | RNA-P10T1-P10T1-1 | Human | Lung | AIS | 1.16e-02 | 1.11e+00 | -0.0764 |
50863 | NTM | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.22e-02 | 6.02e-01 | -0.1408 |
50863 | NTM | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.93e-23 | 1.27e+00 | -0.2116 |
50863 | NTM | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.51e-14 | 1.27e+00 | -0.1941 |
50863 | NTM | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 5.62e-17 | 1.34e+00 | -0.2107 |
50863 | NTM | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 4.48e-22 | 1.17e+00 | -0.2119 |
50863 | NTM | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 6.34e-11 | 1.61e+00 | -0.0238 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657024 | Skin | cSCC | histone modification | 179/4864 | 463/18723 | 9.65e-10 | 3.74e-08 | 179 |
GO:001820810 | Skin | cSCC | peptidyl-proline modification | 37/4864 | 58/18723 | 1.53e-09 | 5.82e-08 | 37 |
GO:000647915 | Skin | cSCC | protein methylation | 67/4864 | 181/18723 | 6.65e-04 | 4.75e-03 | 67 |
GO:000821315 | Skin | cSCC | protein alkylation | 67/4864 | 181/18723 | 6.65e-04 | 4.75e-03 | 67 |
GO:004341411 | Skin | cSCC | macromolecule methylation | 107/4864 | 316/18723 | 1.03e-03 | 6.94e-03 | 107 |
GO:00322593 | Skin | cSCC | methylation | 120/4864 | 364/18723 | 1.61e-03 | 9.93e-03 | 120 |
GO:001657114 | Skin | cSCC | histone methylation | 52/4864 | 141/18723 | 2.74e-03 | 1.54e-02 | 52 |
GO:001820923 | Skin | cSCC | peptidyl-serine modification | 108/4864 | 338/18723 | 7.73e-03 | 3.60e-02 | 108 |
GO:001657010 | Thyroid | PTC | histone modification | 235/5968 | 463/18723 | 1.17e-17 | 1.15e-15 | 235 |
GO:001820817 | Thyroid | PTC | peptidyl-proline modification | 42/5968 | 58/18723 | 2.71e-10 | 8.91e-09 | 42 |
GO:000705116 | Thyroid | PTC | spindle organization | 92/5968 | 184/18723 | 2.21e-07 | 3.92e-06 | 92 |
GO:001820916 | Thyroid | PTC | peptidyl-serine modification | 151/5968 | 338/18723 | 4.61e-07 | 7.51e-06 | 151 |
GO:00070595 | Thyroid | PTC | chromosome segregation | 146/5968 | 346/18723 | 2.99e-05 | 2.87e-04 | 146 |
GO:001657110 | Thyroid | PTC | histone methylation | 67/5968 | 141/18723 | 7.31e-05 | 6.31e-04 | 67 |
GO:000647910 | Thyroid | PTC | protein methylation | 82/5968 | 181/18723 | 1.01e-04 | 8.21e-04 | 82 |
GO:000821310 | Thyroid | PTC | protein alkylation | 82/5968 | 181/18723 | 1.01e-04 | 8.21e-04 | 82 |
GO:00322594 | Thyroid | PTC | methylation | 146/5968 | 364/18723 | 4.99e-04 | 3.26e-03 | 146 |
GO:00434145 | Thyroid | PTC | macromolecule methylation | 127/5968 | 316/18723 | 1.02e-03 | 6.07e-03 | 127 |
GO:001657017 | Thyroid | ATC | histone modification | 243/6293 | 463/18723 | 2.23e-17 | 2.27e-15 | 243 |
GO:000705913 | Thyroid | ATC | chromosome segregation | 183/6293 | 346/18723 | 8.03e-14 | 4.23e-12 | 183 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NTM | SNV | Missense_Mutation | novel | c.49N>C | p.Val17Leu | p.V17L | Q9P121 | protein_coding | tolerated(1) | benign(0) | TCGA-AC-A3W7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
NTM | SNV | Missense_Mutation | c.637N>T | p.Arg213Trp | p.R213W | Q9P121 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AC-A5XU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD | |
NTM | SNV | Missense_Mutation | c.56N>A | p.Gly19Glu | p.G19E | Q9P121 | protein_coding | tolerated(0.34) | benign(0.118) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
NTM | insertion | Frame_Shift_Ins | novel | c.336_337insCCCTCTGATGGCTGCTGTCGTCTCTCAGTCCC | p.Tyr113ProfsTer38 | p.Y113Pfs*38 | Q9P121 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
NTM | deletion | Frame_Shift_Del | rs746798762 | c.3delN | p.Val3_?1 | p.V3_?1 | Q9P121 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
NTM | SNV | Missense_Mutation | novel | c.739N>T | p.Ala247Ser | p.A247S | Q9P121 | protein_coding | deleterious(0.02) | probably_damaging(0.918) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NTM | SNV | Missense_Mutation | c.260N>A | p.Arg87His | p.R87H | Q9P121 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NTM | SNV | Missense_Mutation | c.389N>C | p.Leu130Pro | p.L130P | Q9P121 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NTM | SNV | Missense_Mutation | rs752839570 | c.631N>A | p.Val211Met | p.V211M | Q9P121 | protein_coding | deleterious(0) | possibly_damaging(0.886) | TCGA-AA-3660-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NTM | SNV | Missense_Mutation | c.529N>A | p.Val177Ile | p.V177I | Q9P121 | protein_coding | tolerated(0.21) | benign(0.3) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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