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Gene: NRCAM |
Gene summary for NRCAM |
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Gene information | Species | Human | Gene symbol | NRCAM | Gene ID | 4897 |
Gene name | neuronal cell adhesion molecule | |
Gene Alias | NRCAM | |
Cytomap | 7q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q14CA1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4897 | NRCAM | AEH-subject1 | Human | Endometrium | AEH | 1.04e-03 | 2.64e-01 | -0.3059 |
4897 | NRCAM | AEH-subject2 | Human | Endometrium | AEH | 1.69e-07 | 3.42e-01 | -0.2525 |
4897 | NRCAM | EEC-subject1 | Human | Endometrium | EEC | 4.32e-35 | 7.76e-01 | -0.2682 |
4897 | NRCAM | EEC-subject2 | Human | Endometrium | EEC | 1.96e-05 | 3.68e-01 | -0.2607 |
4897 | NRCAM | EEC-subject5 | Human | Endometrium | EEC | 7.89e-11 | 4.22e-01 | -0.249 |
4897 | NRCAM | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.43e-02 | 1.89e-01 | -0.1934 |
4897 | NRCAM | LZE7T | Human | Esophagus | ESCC | 2.41e-06 | 5.29e-01 | 0.0667 |
4897 | NRCAM | P9T-E | Human | Esophagus | ESCC | 1.71e-09 | 2.75e-01 | 0.1131 |
4897 | NRCAM | P12T-E | Human | Esophagus | ESCC | 1.42e-10 | 3.46e-01 | 0.1122 |
4897 | NRCAM | P16T-E | Human | Esophagus | ESCC | 1.31e-11 | 3.05e-01 | 0.1153 |
4897 | NRCAM | P26T-E | Human | Esophagus | ESCC | 1.37e-23 | 7.63e-01 | 0.1276 |
4897 | NRCAM | P27T-E | Human | Esophagus | ESCC | 2.86e-04 | 2.35e-01 | 0.1055 |
4897 | NRCAM | P30T-E | Human | Esophagus | ESCC | 1.53e-02 | 1.68e-01 | 0.137 |
4897 | NRCAM | P32T-E | Human | Esophagus | ESCC | 7.98e-04 | 1.71e-01 | 0.1666 |
4897 | NRCAM | P48T-E | Human | Esophagus | ESCC | 1.63e-06 | 1.92e-01 | 0.0959 |
4897 | NRCAM | P52T-E | Human | Esophagus | ESCC | 5.76e-11 | 3.64e-01 | 0.1555 |
4897 | NRCAM | P61T-E | Human | Esophagus | ESCC | 1.69e-10 | 2.39e-01 | 0.099 |
4897 | NRCAM | P74T-E | Human | Esophagus | ESCC | 1.97e-04 | 2.08e-01 | 0.1479 |
4897 | NRCAM | P76T-E | Human | Esophagus | ESCC | 3.31e-07 | 1.64e-01 | 0.1207 |
4897 | NRCAM | P83T-E | Human | Esophagus | ESCC | 1.17e-09 | 3.21e-01 | 0.1738 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000836115 | Thyroid | PTC | regulation of cell size | 83/5968 | 181/18723 | 5.45e-05 | 4.84e-04 | 83 |
GO:00305167 | Thyroid | PTC | regulation of axon extension | 47/5968 | 95/18723 | 2.60e-04 | 1.86e-03 | 47 |
GO:00613873 | Thyroid | PTC | regulation of extent of cell growth | 52/5968 | 110/18723 | 5.20e-04 | 3.37e-03 | 52 |
GO:00508089 | Thyroid | PTC | synapse organization | 161/5968 | 426/18723 | 5.11e-03 | 2.36e-02 | 161 |
GO:004863810 | Thyroid | PTC | regulation of developmental growth | 127/5968 | 330/18723 | 6.09e-03 | 2.71e-02 | 127 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
CNTN1 | NRCAM | CNTN1_NRCAM | CNTN | HNSCC | Precancer |
CNTN1 | NRCAM | CNTN1_NRCAM | CNTN | Skin | AK |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NRCAM | SNV | Missense_Mutation | rs773133428 | c.2305N>A | p.Pro769Thr | p.P769T | Q92823 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
NRCAM | SNV | Missense_Mutation | c.2112N>T | p.Gln704His | p.Q704H | Q92823 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
NRCAM | SNV | Missense_Mutation | c.756N>C | p.Leu252Phe | p.L252F | Q92823 | protein_coding | tolerated(0.4) | benign(0.129) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NRCAM | SNV | Missense_Mutation | c.47N>C | p.Arg16Thr | p.R16T | Q92823 | protein_coding | tolerated(0.24) | benign(0.039) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
NRCAM | SNV | Missense_Mutation | c.47N>C | p.Arg16Thr | p.R16T | Q92823 | protein_coding | tolerated(0.24) | benign(0.039) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NRCAM | SNV | Missense_Mutation | c.2364N>C | p.Gln788His | p.Q788H | Q92823 | protein_coding | deleterious(0) | possibly_damaging(0.704) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
NRCAM | insertion | Frame_Shift_Ins | novel | c.3351_3352insACCC | p.Arg1118ThrfsTer36 | p.R1118Tfs*36 | Q92823 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NRCAM | insertion | Frame_Shift_Ins | novel | c.3350_3351insA | p.Arg1118SerfsTer35 | p.R1118Sfs*35 | Q92823 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NRCAM | deletion | Frame_Shift_Del | novel | c.3432delN | p.Phe1144LeufsTer2 | p.F1144Lfs*2 | Q92823 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
NRCAM | SNV | Missense_Mutation | c.1126N>A | p.Glu376Lys | p.E376K | Q92823 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-BI-A0VR-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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