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Gene: NPRL2 |
Gene summary for NPRL2 |
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Gene information | Species | Human | Gene symbol | NPRL2 | Gene ID | 10641 |
Gene name | NPR2 like, GATOR1 complex subunit | |
Gene Alias | FFEVF2 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q8WTW4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10641 | NPRL2 | LZE4T | Human | Esophagus | ESCC | 2.25e-05 | 1.56e-01 | 0.0811 |
10641 | NPRL2 | LZE24T | Human | Esophagus | ESCC | 3.06e-08 | 2.29e-01 | 0.0596 |
10641 | NPRL2 | P2T-E | Human | Esophagus | ESCC | 2.27e-13 | 1.71e-01 | 0.1177 |
10641 | NPRL2 | P4T-E | Human | Esophagus | ESCC | 4.39e-16 | 2.96e-01 | 0.1323 |
10641 | NPRL2 | P5T-E | Human | Esophagus | ESCC | 2.74e-10 | 3.08e-02 | 0.1327 |
10641 | NPRL2 | P8T-E | Human | Esophagus | ESCC | 9.42e-06 | 1.23e-01 | 0.0889 |
10641 | NPRL2 | P9T-E | Human | Esophagus | ESCC | 3.91e-07 | 1.39e-01 | 0.1131 |
10641 | NPRL2 | P10T-E | Human | Esophagus | ESCC | 1.13e-14 | 2.02e-01 | 0.116 |
10641 | NPRL2 | P11T-E | Human | Esophagus | ESCC | 8.84e-13 | 3.72e-01 | 0.1426 |
10641 | NPRL2 | P12T-E | Human | Esophagus | ESCC | 4.15e-16 | 2.64e-01 | 0.1122 |
10641 | NPRL2 | P15T-E | Human | Esophagus | ESCC | 9.86e-04 | 7.27e-02 | 0.1149 |
10641 | NPRL2 | P16T-E | Human | Esophagus | ESCC | 3.53e-08 | 2.01e-01 | 0.1153 |
10641 | NPRL2 | P19T-E | Human | Esophagus | ESCC | 8.31e-04 | 2.89e-01 | 0.1662 |
10641 | NPRL2 | P20T-E | Human | Esophagus | ESCC | 1.24e-12 | 2.40e-01 | 0.1124 |
10641 | NPRL2 | P21T-E | Human | Esophagus | ESCC | 3.06e-12 | 2.74e-01 | 0.1617 |
10641 | NPRL2 | P22T-E | Human | Esophagus | ESCC | 2.43e-17 | 2.31e-01 | 0.1236 |
10641 | NPRL2 | P23T-E | Human | Esophagus | ESCC | 1.87e-22 | 5.10e-01 | 0.108 |
10641 | NPRL2 | P24T-E | Human | Esophagus | ESCC | 1.15e-11 | 1.48e-01 | 0.1287 |
10641 | NPRL2 | P26T-E | Human | Esophagus | ESCC | 1.06e-16 | 3.39e-01 | 0.1276 |
10641 | NPRL2 | P27T-E | Human | Esophagus | ESCC | 9.16e-14 | 1.88e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000703311 | Liver | HCC | vacuole organization | 119/7958 | 180/18723 | 1.22e-10 | 4.25e-09 | 119 |
GO:007149622 | Liver | HCC | cellular response to external stimulus | 191/7958 | 320/18723 | 3.40e-10 | 1.13e-08 | 191 |
GO:003166812 | Liver | HCC | cellular response to extracellular stimulus | 149/7958 | 246/18723 | 7.35e-09 | 1.86e-07 | 149 |
GO:003367322 | Liver | HCC | negative regulation of kinase activity | 144/7958 | 237/18723 | 9.76e-09 | 2.45e-07 | 144 |
GO:004259421 | Liver | HCC | response to starvation | 121/7958 | 197/18723 | 6.08e-08 | 1.28e-06 | 121 |
GO:003166912 | Liver | HCC | cellular response to nutrient levels | 130/7958 | 215/18723 | 7.52e-08 | 1.51e-06 | 130 |
GO:19050371 | Liver | HCC | autophagosome organization | 70/7958 | 103/18723 | 1.52e-07 | 2.82e-06 | 70 |
GO:00105082 | Liver | HCC | positive regulation of autophagy | 81/7958 | 124/18723 | 2.34e-07 | 4.17e-06 | 81 |
GO:00000451 | Liver | HCC | autophagosome assembly | 67/7958 | 99/18723 | 3.56e-07 | 6.07e-06 | 67 |
GO:19021151 | Liver | HCC | regulation of organelle assembly | 110/7958 | 186/18723 | 3.30e-06 | 4.34e-05 | 110 |
GO:000926712 | Liver | HCC | cellular response to starvation | 94/7958 | 156/18723 | 5.61e-06 | 6.95e-05 | 94 |
GO:00319291 | Liver | HCC | TOR signaling | 78/7958 | 126/18723 | 8.49e-06 | 9.97e-05 | 78 |
GO:00440881 | Liver | HCC | regulation of vacuole organization | 33/7958 | 45/18723 | 2.69e-05 | 2.79e-04 | 33 |
GO:0032006 | Liver | HCC | regulation of TOR signaling | 63/7958 | 104/18723 | 1.50e-04 | 1.20e-03 | 63 |
GO:20007851 | Liver | HCC | regulation of autophagosome assembly | 28/7958 | 39/18723 | 2.02e-04 | 1.56e-03 | 28 |
GO:19909281 | Liver | HCC | response to amino acid starvation | 33/7958 | 49/18723 | 3.86e-04 | 2.62e-03 | 33 |
GO:00341981 | Liver | HCC | cellular response to amino acid starvation | 30/7958 | 46/18723 | 1.56e-03 | 8.23e-03 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041505 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa0415013 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa041502 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0415011 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPRL2 | SNV | Missense_Mutation | rs149128231 | c.640N>C | p.Asp214His | p.D214H | Q8WTW4 | protein_coding | deleterious(0) | possibly_damaging(0.843) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
NPRL2 | insertion | Nonsense_Mutation | novel | c.1051_1052insGTTTCTGGGCCAGCCGTGGGAGACCCAGCAGTGAATGAA | p.Tyr351delinsCysPheTrpAlaSerArgGlyArgProSerSerGluTerAsn | p.Y351delinsCFWASRGRPSSE*N | Q8WTW4 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NPRL2 | SNV | Missense_Mutation | novel | c.196N>A | p.Gly66Ser | p.G66S | Q8WTW4 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NPRL2 | SNV | Missense_Mutation | novel | c.1054N>A | p.Asp352Asn | p.D352N | Q8WTW4 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-MA-AA3Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NPRL2 | SNV | Missense_Mutation | c.898N>T | p.Arg300Cys | p.R300C | Q8WTW4 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NPRL2 | SNV | Missense_Mutation | novel | c.490N>T | p.Pro164Ser | p.P164S | Q8WTW4 | protein_coding | tolerated(0.78) | benign(0.053) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NPRL2 | SNV | Missense_Mutation | novel | c.257N>A | p.Gly86Asp | p.G86D | Q8WTW4 | protein_coding | deleterious(0.02) | probably_damaging(0.966) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NPRL2 | SNV | Missense_Mutation | novel | c.278N>T | p.Ala93Val | p.A93V | Q8WTW4 | protein_coding | tolerated(0.22) | benign(0.02) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
NPRL2 | SNV | Missense_Mutation | c.737N>A | p.Cys246Tyr | p.C246Y | Q8WTW4 | protein_coding | deleterious(0.02) | benign(0.189) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NPRL2 | SNV | Missense_Mutation | novel | c.490N>T | p.Pro164Ser | p.P164S | Q8WTW4 | protein_coding | tolerated(0.78) | benign(0.053) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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