Tissue | Expression Dynamics | Abbreviation |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003310821 | Stomach | CSG | mitochondrial respiratory chain complex assembly | 22/1034 | 93/18723 | 4.81e-09 | 4.99e-07 | 22 |
GO:001025721 | Stomach | CSG | NADH dehydrogenase complex assembly | 17/1034 | 57/18723 | 6.22e-09 | 6.10e-07 | 17 |
GO:003298121 | Stomach | CSG | mitochondrial respiratory chain complex I assembly | 17/1034 | 57/18723 | 6.22e-09 | 6.10e-07 | 17 |
GO:001025731 | Stomach | CAG | NADH dehydrogenase complex assembly | 12/552 | 57/18723 | 8.08e-08 | 7.84e-06 | 12 |
GO:003298131 | Stomach | CAG | mitochondrial respiratory chain complex I assembly | 12/552 | 57/18723 | 8.08e-08 | 7.84e-06 | 12 |
GO:003310831 | Stomach | CAG | mitochondrial respiratory chain complex assembly | 14/552 | 93/18723 | 5.56e-07 | 4.06e-05 | 14 |
GO:00102575 | Stomach | SIM | NADH dehydrogenase complex assembly | 15/708 | 57/18723 | 2.01e-09 | 2.79e-07 | 15 |
GO:00329815 | Stomach | SIM | mitochondrial respiratory chain complex I assembly | 15/708 | 57/18723 | 2.01e-09 | 2.79e-07 | 15 |
GO:00331085 | Stomach | SIM | mitochondrial respiratory chain complex assembly | 17/708 | 93/18723 | 6.41e-08 | 6.30e-06 | 17 |
GO:001025725 | Thyroid | HT | NADH dehydrogenase complex assembly | 20/1272 | 57/18723 | 4.06e-10 | 4.80e-08 | 20 |
GO:003298125 | Thyroid | HT | mitochondrial respiratory chain complex I assembly | 20/1272 | 57/18723 | 4.06e-10 | 4.80e-08 | 20 |
GO:003310825 | Thyroid | HT | mitochondrial respiratory chain complex assembly | 24/1272 | 93/18723 | 8.72e-09 | 7.58e-07 | 24 |
GO:0033108111 | Thyroid | PTC | mitochondrial respiratory chain complex assembly | 65/5968 | 93/18723 | 5.60e-14 | 3.21e-12 | 65 |
GO:0010257111 | Thyroid | PTC | NADH dehydrogenase complex assembly | 43/5968 | 57/18723 | 1.73e-11 | 6.81e-10 | 43 |
GO:0032981111 | Thyroid | PTC | mitochondrial respiratory chain complex I assembly | 43/5968 | 57/18723 | 1.73e-11 | 6.81e-10 | 43 |
GO:003310832 | Thyroid | ATC | mitochondrial respiratory chain complex assembly | 65/6293 | 93/18723 | 8.86e-13 | 3.81e-11 | 65 |
GO:001025732 | Thyroid | ATC | NADH dehydrogenase complex assembly | 43/6293 | 57/18723 | 1.20e-10 | 3.75e-09 | 43 |
GO:003298132 | Thyroid | ATC | mitochondrial respiratory chain complex I assembly | 43/6293 | 57/18723 | 1.20e-10 | 3.75e-09 | 43 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520820 | Cervix | CC | Chemical carcinogenesis - reactive oxygen species | 92/1267 | 223/8465 | 4.71e-22 | 5.09e-20 | 3.01e-20 | 92 |
hsa0501220 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa0019018 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa0502018 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa0541520 | Cervix | CC | Diabetic cardiomyopathy | 76/1267 | 203/8465 | 1.40e-15 | 6.46e-14 | 3.82e-14 | 76 |
hsa0501018 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0501618 | Cervix | CC | Huntington disease | 94/1267 | 306/8465 | 8.49e-13 | 3.06e-11 | 1.81e-11 | 94 |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0493218 | Cervix | CC | Non-alcoholic fatty liver disease | 58/1267 | 155/8465 | 3.58e-12 | 1.05e-10 | 6.23e-11 | 58 |
hsa0471420 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa0501418 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa0472318 | Cervix | CC | Retrograde endocannabinoid signaling | 42/1267 | 148/8465 | 1.79e-05 | 1.42e-04 | 8.40e-05 | 42 |
hsa05208110 | Cervix | CC | Chemical carcinogenesis - reactive oxygen species | 92/1267 | 223/8465 | 4.71e-22 | 5.09e-20 | 3.01e-20 | 92 |
hsa05012110 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa0019019 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa0502019 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa05415110 | Cervix | CC | Diabetic cardiomyopathy | 76/1267 | 203/8465 | 1.40e-15 | 6.46e-14 | 3.82e-14 | 76 |
hsa0501019 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0501619 | Cervix | CC | Huntington disease | 94/1267 | 306/8465 | 8.49e-13 | 3.06e-11 | 1.81e-11 | 94 |
hsa0502219 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDUFB11 | SNV | Missense_Mutation | novel | c.406G>T | p.Val136Leu | p.V136L | Q9NX14 | protein_coding | tolerated(0.25) | possibly_damaging(0.472) | TCGA-E9-A22A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
NDUFB11 | SNV | Missense_Mutation | rs781871228 | c.140G>A | p.Arg47Gln | p.R47Q | Q9NX14 | protein_coding | tolerated(0.19) | benign(0.086) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
NDUFB11 | SNV | Missense_Mutation | rs782460503 | c.386N>A | p.Arg129His | p.R129H | Q9NX14 | protein_coding | deleterious(0.02) | benign(0.103) | TCGA-EA-A3HT-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
NDUFB11 | SNV | Missense_Mutation | | c.263N>C | p.Arg88Pro | p.R88P | Q9NX14 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFB11 | SNV | Missense_Mutation | novel | c.11N>A | p.Gly4Glu | p.G4E | Q9NX14 | protein_coding | tolerated_low_confidence(0.07) | benign(0.031) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
NDUFB11 | SNV | Missense_Mutation | novel | c.233A>C | p.Lys78Thr | p.K78T | Q9NX14 | protein_coding | tolerated(0.19) | benign(0.122) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFB11 | SNV | Missense_Mutation | rs782682185 | c.283G>A | p.Val95Ile | p.V95I | Q9NX14 | protein_coding | tolerated(1) | benign(0.009) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
NDUFB11 | SNV | Missense_Mutation | rs782460503 | c.386N>A | p.Arg129His | p.R129H | Q9NX14 | protein_coding | deleterious(0.02) | benign(0.103) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFB11 | SNV | Missense_Mutation | rs782460503 | c.386N>A | p.Arg129His | p.R129H | Q9NX14 | protein_coding | deleterious(0.02) | benign(0.103) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
NDUFB11 | SNV | Missense_Mutation | | c.263N>A | p.Arg88Gln | p.R88Q | Q9NX14 | protein_coding | tolerated(0.09) | benign(0.095) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |