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Gene: MT1X |
Gene summary for MT1X |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MT1X | Gene ID | 4501 |
| Gene name | metallothionein 1X | |
| Gene Alias | MT-1l | |
| Cytomap | 16q13 | |
| Gene Type | protein-coding | GO ID | GO:0006873 | UniProtAcc | A0A140VJP8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 4501 | MT1X | GSM4909277 | Human | Breast | Precancer | 4.40e-02 | 7.90e-01 | 0.0177 |
| 4501 | MT1X | GSM4909281 | Human | Breast | IDC | 9.26e-06 | 3.98e-01 | 0.21 |
| 4501 | MT1X | GSM4909282 | Human | Breast | IDC | 6.13e-81 | 1.17e+00 | -0.0288 |
| 4501 | MT1X | GSM4909285 | Human | Breast | IDC | 1.15e-23 | 7.01e-01 | 0.21 |
| 4501 | MT1X | GSM4909290 | Human | Breast | IDC | 1.04e-05 | -4.61e-01 | 0.2096 |
| 4501 | MT1X | GSM4909293 | Human | Breast | IDC | 8.88e-04 | -3.10e-01 | 0.1581 |
| 4501 | MT1X | GSM4909297 | Human | Breast | IDC | 8.50e-07 | -1.18e-01 | 0.1517 |
| 4501 | MT1X | GSM4909298 | Human | Breast | IDC | 6.83e-12 | -4.81e-01 | 0.1551 |
| 4501 | MT1X | GSM4909299 | Human | Breast | IDC | 3.87e-03 | 4.14e-01 | 0.035 |
| 4501 | MT1X | GSM4909301 | Human | Breast | IDC | 1.81e-03 | -3.38e-01 | 0.1577 |
| 4501 | MT1X | GSM4909302 | Human | Breast | IDC | 6.18e-12 | -5.35e-01 | 0.1545 |
| 4501 | MT1X | GSM4909308 | Human | Breast | IDC | 1.03e-13 | -5.79e-01 | 0.158 |
| 4501 | MT1X | GSM4909309 | Human | Breast | IDC | 6.07e-09 | 5.35e-01 | 0.0483 |
| 4501 | MT1X | GSM4909311 | Human | Breast | IDC | 7.06e-29 | 2.60e-01 | 0.1534 |
| 4501 | MT1X | GSM4909312 | Human | Breast | IDC | 3.78e-06 | -2.50e-01 | 0.1552 |
| 4501 | MT1X | GSM4909313 | Human | Breast | IDC | 2.52e-06 | 3.55e-01 | 0.0391 |
| 4501 | MT1X | GSM4909318 | Human | Breast | IDC | 5.53e-03 | -6.83e-01 | 0.2031 |
| 4501 | MT1X | GSM4909319 | Human | Breast | IDC | 6.31e-33 | -6.52e-01 | 0.1563 |
| 4501 | MT1X | GSM4909320 | Human | Breast | IDC | 2.72e-03 | -4.68e-01 | 0.1575 |
| 4501 | MT1X | GSM4909321 | Human | Breast | IDC | 1.53e-24 | -6.38e-01 | 0.1559 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:001003825 | Cervix | N_HPV | response to metal ion | 27/534 | 373/18723 | 1.00e-05 | 3.46e-04 | 27 |
| GO:009875424 | Cervix | N_HPV | detoxification | 15/534 | 152/18723 | 3.05e-05 | 8.02e-04 | 15 |
| GO:007124814 | Cervix | N_HPV | cellular response to metal ion | 16/534 | 197/18723 | 1.75e-04 | 3.00e-03 | 16 |
| GO:005507623 | Cervix | N_HPV | transition metal ion homeostasis | 12/534 | 138/18723 | 6.00e-04 | 7.86e-03 | 12 |
| GO:00712419 | Cervix | N_HPV | cellular response to inorganic substance | 16/534 | 226/18723 | 8.02e-04 | 9.98e-03 | 16 |
| GO:004691613 | Cervix | N_HPV | cellular transition metal ion homeostasis | 10/534 | 115/18723 | 1.68e-03 | 1.72e-02 | 10 |
| GO:009750113 | Cervix | N_HPV | stress response to metal ion | 4/534 | 19/18723 | 1.80e-03 | 1.81e-02 | 4 |
| GO:004668614 | Cervix | N_HPV | response to cadmium ion | 7/534 | 68/18723 | 3.18e-03 | 2.64e-02 | 7 |
| GO:00068824 | Cervix | N_HPV | cellular zinc ion homeostasis | 5/534 | 38/18723 | 4.27e-03 | 3.26e-02 | 5 |
| GO:00550694 | Cervix | N_HPV | zinc ion homeostasis | 5/534 | 40/18723 | 5.35e-03 | 3.84e-02 | 5 |
| GO:001004312 | Cervix | N_HPV | response to zinc ion | 6/534 | 58/18723 | 6.04e-03 | 4.17e-02 | 6 |
| GO:004668814 | Cervix | N_HPV | response to copper ion | 5/534 | 42/18723 | 6.60e-03 | 4.45e-02 | 5 |
| GO:00725031 | Cervix | N_HPV | cellular divalent inorganic cation homeostasis | 24/534 | 486/18723 | 6.76e-03 | 4.52e-02 | 24 |
| GO:00712806 | Cervix | N_HPV | cellular response to copper ion | 4/534 | 28/18723 | 7.78e-03 | 4.97e-02 | 4 |
| GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
| GO:0055076 | Colorectum | AD | transition metal ion homeostasis | 53/3918 | 138/18723 | 1.89e-06 | 5.65e-05 | 53 |
| GO:0046916 | Colorectum | AD | cellular transition metal ion homeostasis | 43/3918 | 115/18723 | 3.62e-05 | 6.56e-04 | 43 |
| GO:0098754 | Colorectum | AD | detoxification | 53/3918 | 152/18723 | 4.63e-05 | 7.98e-04 | 53 |
| GO:0046686 | Colorectum | AD | response to cadmium ion | 27/3918 | 68/18723 | 3.19e-04 | 3.80e-03 | 27 |
| GO:0010038 | Colorectum | AD | response to metal ion | 106/3918 | 373/18723 | 3.22e-04 | 3.83e-03 | 106 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0497812 | Breast | IDC | Mineral absorption | 13/867 | 60/8465 | 6.73e-03 | 3.42e-02 | 2.56e-02 | 13 |
| hsa0497813 | Breast | IDC | Mineral absorption | 13/867 | 60/8465 | 6.73e-03 | 3.42e-02 | 2.56e-02 | 13 |
| hsa0497821 | Breast | DCIS | Mineral absorption | 13/846 | 60/8465 | 5.48e-03 | 2.81e-02 | 2.07e-02 | 13 |
| hsa0497831 | Breast | DCIS | Mineral absorption | 13/846 | 60/8465 | 5.48e-03 | 2.81e-02 | 2.07e-02 | 13 |
| hsa0497810 | Liver | Cyst | Mineral absorption | 8/339 | 60/8465 | 2.53e-03 | 2.08e-02 | 1.72e-02 | 8 |
| hsa0497811 | Liver | Cyst | Mineral absorption | 8/339 | 60/8465 | 2.53e-03 | 2.08e-02 | 1.72e-02 | 8 |
| hsa0497814 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
| hsa0497815 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MT1X | insertion | Nonsense_Mutation | novel | c.32_33insTCAGGGGGCTGCTGGCTGAGCCCCAATGCT | p.Gly11_Ser12insGlnGlyAlaAlaGlyTerAlaProMetLeu | p.G11_S12insQGAAG*APML | P80297 | protein_coding | TCGA-A2-A04T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | ||
| MT1X | deletion | In_Frame_Del | novel | c.55_69delNNNNNNNNNNNNNNN | p.Lys22_Cys26del | p.K22_C26del | P80297 | protein_coding | TCGA-OL-A5RY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| MT1X | SNV | Missense_Mutation | rs376283692 | c.64N>G | p.Lys22Glu | p.K22E | P80297 | protein_coding | deleterious(0.03) | probably_damaging(0.989) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
| MT1X | insertion | In_Frame_Ins | novel | c.28_28+1insTTGGCTCCTGTGCCTGTGCCGGCTCCT | p.Ser18_Cys19insPheGlySerCysAlaCysAlaGlySer | p.S18_C19insFGSCACAGS | P80297 | protein_coding | TCGA-FP-7829-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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