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Gene: MIIP |
Gene summary for MIIP |
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Gene information | Species | Human | Gene symbol | MIIP | Gene ID | 60672 |
Gene name | migration and invasion inhibitory protein | |
Gene Alias | IIP45 | |
Cytomap | 1p36.22 | |
Gene Type | protein-coding | GO ID | GO:0000086 | UniProtAcc | Q5JXC2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60672 | MIIP | LZE4T | Human | Esophagus | ESCC | 3.20e-04 | 1.19e-01 | 0.0811 |
60672 | MIIP | LZE7T | Human | Esophagus | ESCC | 1.20e-10 | 5.72e-01 | 0.0667 |
60672 | MIIP | LZE8T | Human | Esophagus | ESCC | 5.75e-03 | 1.34e-01 | 0.067 |
60672 | MIIP | LZE20T | Human | Esophagus | ESCC | 8.44e-05 | 1.09e-01 | 0.0662 |
60672 | MIIP | LZE24T | Human | Esophagus | ESCC | 1.02e-19 | 5.06e-01 | 0.0596 |
60672 | MIIP | LZE21T | Human | Esophagus | ESCC | 2.24e-06 | 3.54e-01 | 0.0655 |
60672 | MIIP | LZE6T | Human | Esophagus | ESCC | 4.14e-07 | 3.49e-01 | 0.0845 |
60672 | MIIP | P1T-E | Human | Esophagus | ESCC | 3.88e-05 | 2.08e-01 | 0.0875 |
60672 | MIIP | P2T-E | Human | Esophagus | ESCC | 1.78e-26 | 4.03e-01 | 0.1177 |
60672 | MIIP | P4T-E | Human | Esophagus | ESCC | 1.50e-17 | 4.37e-01 | 0.1323 |
60672 | MIIP | P5T-E | Human | Esophagus | ESCC | 1.78e-28 | 4.36e-01 | 0.1327 |
60672 | MIIP | P8T-E | Human | Esophagus | ESCC | 1.38e-17 | 2.99e-01 | 0.0889 |
60672 | MIIP | P9T-E | Human | Esophagus | ESCC | 2.20e-11 | 2.32e-01 | 0.1131 |
60672 | MIIP | P10T-E | Human | Esophagus | ESCC | 7.18e-31 | 4.37e-01 | 0.116 |
60672 | MIIP | P11T-E | Human | Esophagus | ESCC | 1.10e-12 | 5.63e-01 | 0.1426 |
60672 | MIIP | P12T-E | Human | Esophagus | ESCC | 7.41e-21 | 3.17e-01 | 0.1122 |
60672 | MIIP | P15T-E | Human | Esophagus | ESCC | 4.18e-18 | 3.43e-01 | 0.1149 |
60672 | MIIP | P16T-E | Human | Esophagus | ESCC | 6.51e-18 | 3.68e-01 | 0.1153 |
60672 | MIIP | P17T-E | Human | Esophagus | ESCC | 1.26e-15 | 5.52e-01 | 0.1278 |
60672 | MIIP | P19T-E | Human | Esophagus | ESCC | 3.48e-15 | 8.23e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004483911 | Skin | cSCC | cell cycle G2/M phase transition | 61/4864 | 148/18723 | 3.61e-05 | 3.90e-04 | 61 |
GO:00103892 | Skin | cSCC | regulation of G2/M transition of mitotic cell cycle | 37/4864 | 94/18723 | 3.02e-03 | 1.67e-02 | 37 |
GO:19027492 | Skin | cSCC | regulation of cell cycle G2/M phase transition | 38/4864 | 102/18723 | 7.85e-03 | 3.65e-02 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MIIP | SNV | Missense_Mutation | c.397N>A | p.Asp133Asn | p.D133N | Q5JXC2 | protein_coding | tolerated(0.19) | benign(0.342) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MIIP | SNV | Missense_Mutation | novel | c.574A>C | p.Thr192Pro | p.T192P | Q5JXC2 | protein_coding | deleterious(0) | possibly_damaging(0.731) | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD |
MIIP | SNV | Missense_Mutation | rs779477951 | c.616N>T | p.Arg206Trp | p.R206W | Q5JXC2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A150-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
MIIP | insertion | Nonsense_Mutation | novel | c.248_249insGAGATCGAGACCATCCTGGCTAACACGGTGAAAC | p.Asp83GlufsTer11 | p.D83Efs*11 | Q5JXC2 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MIIP | SNV | Missense_Mutation | c.1047N>C | p.Gln349His | p.Q349H | Q5JXC2 | protein_coding | tolerated(0.19) | possibly_damaging(0.834) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MIIP | SNV | Missense_Mutation | c.232G>A | p.Asp78Asn | p.D78N | Q5JXC2 | protein_coding | deleterious(0.02) | possibly_damaging(0.55) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MIIP | SNV | Missense_Mutation | rs541833150 | c.898N>T | p.Arg300Trp | p.R300W | Q5JXC2 | protein_coding | deleterious(0) | probably_damaging(0.942) | TCGA-AD-6888-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
MIIP | SNV | Missense_Mutation | rs779477951 | c.616C>T | p.Arg206Trp | p.R206W | Q5JXC2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MIIP | SNV | Missense_Mutation | c.875C>T | p.Pro292Leu | p.P292L | Q5JXC2 | protein_coding | deleterious(0) | possibly_damaging(0.645) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MIIP | SNV | Missense_Mutation | novel | c.311N>G | p.Glu104Gly | p.E104G | Q5JXC2 | protein_coding | tolerated(0.21) | benign(0.022) | TCGA-F4-6808-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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