Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/LOXL2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/LOXL2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/LOXL2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009872713 | Oral cavity | EOLP | maintenance of cell number | 38/2218 | 134/18723 | 1.74e-07 | 5.61e-06 | 38 |
GO:000632515 | Oral cavity | EOLP | chromatin organization | 84/2218 | 409/18723 | 2.68e-07 | 8.16e-06 | 84 |
GO:000166624 | Oral cavity | EOLP | response to hypoxia | 65/2218 | 307/18723 | 2.00e-06 | 4.55e-05 | 65 |
GO:007048224 | Oral cavity | EOLP | response to oxygen levels | 70/2218 | 347/18723 | 5.00e-06 | 1.02e-04 | 70 |
GO:003629324 | Oral cavity | EOLP | response to decreased oxygen levels | 66/2218 | 322/18723 | 5.31e-06 | 1.07e-04 | 66 |
GO:004354210 | Oral cavity | EOLP | endothelial cell migration | 59/2218 | 279/18723 | 6.05e-06 | 1.19e-04 | 59 |
GO:001820521 | Oral cavity | EOLP | peptidyl-lysine modification | 72/2218 | 376/18723 | 2.38e-05 | 3.56e-04 | 72 |
GO:001003826 | Oral cavity | EOLP | response to metal ion | 71/2218 | 373/18723 | 3.32e-05 | 4.65e-04 | 71 |
GO:005067317 | Oral cavity | EOLP | epithelial cell proliferation | 75/2218 | 437/18723 | 5.90e-04 | 4.97e-03 | 75 |
GO:002290025 | Oral cavity | EOLP | electron transport chain | 35/2218 | 175/18723 | 1.26e-03 | 9.04e-03 | 35 |
GO:000609125 | Oral cavity | EOLP | generation of precursor metabolites and energy | 79/2218 | 490/18723 | 2.65e-03 | 1.59e-02 | 79 |
GO:003019811 | Oral cavity | EOLP | extracellular matrix organization | 52/2218 | 301/18723 | 3.29e-03 | 1.90e-02 | 52 |
GO:004306211 | Oral cavity | EOLP | extracellular structure organization | 52/2218 | 302/18723 | 3.52e-03 | 2.01e-02 | 52 |
GO:004522911 | Oral cavity | EOLP | external encapsulating structure organization | 52/2218 | 304/18723 | 4.04e-03 | 2.23e-02 | 52 |
GO:00020622 | Oral cavity | EOLP | chondrocyte differentiation | 22/2218 | 106/18723 | 5.93e-03 | 2.98e-02 | 22 |
GO:004668816 | Oral cavity | EOLP | response to copper ion | 11/2218 | 42/18723 | 8.21e-03 | 3.86e-02 | 11 |
GO:001071711 | Oral cavity | EOLP | regulation of epithelial to mesenchymal transition | 20/2218 | 99/18723 | 1.14e-02 | 4.99e-02 | 20 |
GO:000166725 | Oral cavity | NEOLP | ameboidal-type cell migration | 96/2005 | 475/18723 | 5.16e-10 | 4.14e-08 | 96 |
GO:001063123 | Oral cavity | NEOLP | epithelial cell migration | 77/2005 | 357/18723 | 1.32e-09 | 9.43e-08 | 77 |
GO:009013023 | Oral cavity | NEOLP | tissue migration | 78/2005 | 365/18723 | 1.61e-09 | 1.06e-07 | 78 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LOXL2 | SNV | Missense_Mutation | novel | c.199N>A | p.His67Asn | p.H67N | Q9Y4K0 | protein_coding | tolerated(0.24) | benign(0.087) | TCGA-5T-A9QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
LOXL2 | SNV | Missense_Mutation | | c.447N>C | p.Lys149Asn | p.K149N | Q9Y4K0 | protein_coding | tolerated(0.12) | benign(0.093) | TCGA-AQ-A0Y5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | SD |
LOXL2 | insertion | In_Frame_Ins | novel | c.1901_1902insAAATGTGTGTTTAATTTGTTATTC | p.Val634_Phe635insAsnValCysLeuIleCysTyrSer | p.V634_F635insNVCLICYS | Q9Y4K0 | protein_coding | | | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
LOXL2 | deletion | Frame_Shift_Del | novel | c.1615delN | p.Ala539ProfsTer103 | p.A539Pfs*103 | Q9Y4K0 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
LOXL2 | SNV | Missense_Mutation | rs768171524 | c.2212N>A | p.Gly738Ser | p.G738S | Q9Y4K0 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LOXL2 | SNV | Missense_Mutation | novel | c.877N>C | p.Asn293His | p.N293H | Q9Y4K0 | protein_coding | tolerated(0.32) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LOXL2 | SNV | Missense_Mutation | novel | c.1295N>G | p.Gln432Arg | p.Q432R | Q9Y4K0 | protein_coding | deleterious(0.03) | benign(0.009) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
LOXL2 | SNV | Missense_Mutation | novel | c.96N>A | p.His32Gln | p.H32Q | Q9Y4K0 | protein_coding | tolerated_low_confidence(0.12) | benign(0) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
LOXL2 | SNV | Missense_Mutation | rs748831417 | c.1322N>A | p.Arg441His | p.R441H | Q9Y4K0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
LOXL2 | SNV | Missense_Mutation | rs755780161 | c.2068C>T | p.Arg690Cys | p.R690C | Q9Y4K0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4017 | LOXL2 | DRUGGABLE GENOME, TRANSCRIPTION FACTOR, ENZYME | | GS-6624 | SIMTUZUMAB | |
4017 | LOXL2 | DRUGGABLE GENOME, TRANSCRIPTION FACTOR, ENZYME | inhibitor | 385612245 | | |
4017 | LOXL2 | DRUGGABLE GENOME, TRANSCRIPTION FACTOR, ENZYME | inhibitor | CHEMBL2109667 | SIMTUZUMAB | |
4017 | LOXL2 | DRUGGABLE GENOME, TRANSCRIPTION FACTOR, ENZYME | inhibitor | 385612244 | | |
4017 | LOXL2 | DRUGGABLE GENOME, TRANSCRIPTION FACTOR, ENZYME | inhibitor | 252166622 | SIMTUZUMAB | |