GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1902905113 | Thyroid | PTC | positive regulation of supramolecular fiber organization | 114/5968 | 209/18723 | 8.48e-12 | 3.57e-10 | 114 |
GO:005149526 | Thyroid | PTC | positive regulation of cytoskeleton organization | 121/5968 | 226/18723 | 1.04e-11 | 4.27e-10 | 121 |
GO:0031346110 | Thyroid | PTC | positive regulation of cell projection organization | 173/5968 | 353/18723 | 1.09e-11 | 4.40e-10 | 173 |
GO:0051348113 | Thyroid | PTC | negative regulation of transferase activity | 137/5968 | 268/18723 | 3.78e-11 | 1.36e-09 | 137 |
GO:0031397113 | Thyroid | PTC | negative regulation of protein ubiquitination | 55/5968 | 83/18723 | 1.26e-10 | 4.28e-09 | 55 |
GO:0032535112 | Thyroid | PTC | regulation of cellular component size | 181/5968 | 383/18723 | 1.70e-10 | 5.64e-09 | 181 |
GO:000726519 | Thyroid | PTC | Ras protein signal transduction | 162/5968 | 337/18723 | 3.16e-10 | 1.02e-08 | 162 |
GO:1903321113 | Thyroid | PTC | negative regulation of protein modification by small protein conjugation or removal | 59/5968 | 95/18723 | 1.26e-09 | 3.63e-08 | 59 |
GO:0001558111 | Thyroid | PTC | regulation of cell growth | 188/5968 | 414/18723 | 4.13e-09 | 1.09e-07 | 188 |
GO:0051017112 | Thyroid | PTC | actin filament bundle assembly | 83/5968 | 157/18723 | 3.73e-08 | 8.18e-07 | 83 |
GO:0061572112 | Thyroid | PTC | actin filament bundle organization | 84/5968 | 161/18723 | 6.75e-08 | 1.40e-06 | 84 |
GO:0010975110 | Thyroid | PTC | regulation of neuron projection development | 194/5968 | 445/18723 | 1.05e-07 | 2.08e-06 | 194 |
GO:001072018 | Thyroid | PTC | positive regulation of cell development | 138/5968 | 298/18723 | 1.13e-07 | 2.22e-06 | 138 |
GO:0051444113 | Thyroid | PTC | negative regulation of ubiquitin-protein transferase activity | 17/5968 | 19/18723 | 2.98e-07 | 5.09e-06 | 17 |
GO:006156419 | Thyroid | PTC | axon development | 199/5968 | 467/18723 | 5.27e-07 | 8.53e-06 | 199 |
GO:0051438111 | Thyroid | PTC | regulation of ubiquitin-protein transferase activity | 34/5968 | 53/18723 | 1.36e-06 | 1.95e-05 | 34 |
GO:004867517 | Thyroid | PTC | axon extension | 63/5968 | 120/18723 | 2.14e-06 | 2.89e-05 | 63 |
GO:000740918 | Thyroid | PTC | axonogenesis | 178/5968 | 418/18723 | 2.17e-06 | 2.91e-05 | 178 |
GO:005076914 | Thyroid | PTC | positive regulation of neurogenesis | 105/5968 | 225/18723 | 2.28e-06 | 3.05e-05 | 105 |
GO:0032231112 | Thyroid | PTC | regulation of actin filament bundle assembly | 56/5968 | 105/18723 | 4.10e-06 | 5.11e-05 | 56 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LIMK1 | SNV | Missense_Mutation | | c.1567N>A | p.Gly523Ser | p.G523S | P53667 | protein_coding | deleterious(0.03) | probably_damaging(0.981) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIMK1 | SNV | Missense_Mutation | novel | c.139N>T | p.Ala47Ser | p.A47S | P53667 | protein_coding | tolerated(0.87) | benign(0.007) | TCGA-PE-A5DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | CR |
LIMK1 | insertion | Frame_Shift_Ins | novel | c.544_545insACCAGGAAGCTTCACTGAGCTTCAGCAGCCAGAGTTT | p.Ile182AsnfsTer14 | p.I182Nfs*14 | P53667 | protein_coding | | | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIMK1 | insertion | Frame_Shift_Ins | novel | c.1712_1713insC | p.Asn574LysfsTer71 | p.N574Kfs*71 | P53667 | protein_coding | | | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIMK1 | SNV | Missense_Mutation | | c.358G>A | p.Asp120Asn | p.D120N | P53667 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
LIMK1 | SNV | Missense_Mutation | | c.1557N>C | p.Glu519Asp | p.E519D | P53667 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LIMK1 | SNV | Missense_Mutation | | c.646N>A | p.Ser216Thr | p.S216T | P53667 | protein_coding | tolerated(0.11) | benign(0.117) | TCGA-EA-A556-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LIMK1 | SNV | Missense_Mutation | rs782256257 | c.985C>T | p.Arg329Trp | p.R329W | P53667 | protein_coding | deleterious(0) | possibly_damaging(0.462) | TCGA-IR-A3LC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | Complete Response |
LIMK1 | SNV | Missense_Mutation | novel | c.1563N>G | p.Ile521Met | p.I521M | P53667 | protein_coding | tolerated(0.71) | benign(0.323) | TCGA-PN-A8MA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
LIMK1 | SNV | Missense_Mutation | novel | c.1864N>C | p.Glu622Gln | p.E622Q | P53667 | protein_coding | deleterious(0.04) | possibly_damaging(0.65) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | PAZOPANIB | PAZOPANIB | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | GO-6976 | GO-6976 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | CENISERTIB | CENISERTIB | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | TAE-684 | TAE-684 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | BMS-345541 | BMS-345541 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | TCMDC-125758 | CHEMBL546797 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 249565797 | | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | SB-220025 | SB-220025 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | RG-1530 | RG-1530 | |
3984 | LIMK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 363894217 | VORUCICLIB | |