Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00081542 | Colorectum | MSS | actin polymerization or depolymerization | 79/3467 | 218/18723 | 4.14e-10 | 3.49e-08 | 79 |
GO:00080642 | Colorectum | MSS | regulation of actin polymerization or depolymerization | 70/3467 | 188/18723 | 1.06e-09 | 8.25e-08 | 70 |
GO:00308322 | Colorectum | MSS | regulation of actin filament length | 70/3467 | 189/18723 | 1.38e-09 | 1.03e-07 | 70 |
GO:00329562 | Colorectum | MSS | regulation of actin cytoskeleton organization | 113/3467 | 358/18723 | 1.46e-09 | 1.07e-07 | 113 |
GO:01100532 | Colorectum | MSS | regulation of actin filament organization | 92/3467 | 278/18723 | 3.61e-09 | 2.42e-07 | 92 |
GO:00224112 | Colorectum | MSS | cellular component disassembly | 130/3467 | 443/18723 | 1.44e-08 | 8.46e-07 | 130 |
GO:00106392 | Colorectum | MSS | negative regulation of organelle organization | 102/3467 | 348/18723 | 5.36e-07 | 2.05e-05 | 102 |
GO:00329842 | Colorectum | MSS | protein-containing complex disassembly | 69/3467 | 224/18723 | 5.61e-06 | 1.50e-04 | 69 |
GO:00615722 | Colorectum | MSS | actin filament bundle organization | 50/3467 | 161/18723 | 8.18e-05 | 1.35e-03 | 50 |
GO:00510172 | Colorectum | MSS | actin filament bundle assembly | 49/3467 | 157/18723 | 8.35e-05 | 1.36e-03 | 49 |
GO:00060662 | Colorectum | MSS | alcohol metabolic process | 92/3467 | 353/18723 | 2.57e-04 | 3.46e-03 | 92 |
GO:19029042 | Colorectum | MSS | negative regulation of supramolecular fiber organization | 49/3467 | 167/18723 | 4.30e-04 | 5.23e-03 | 49 |
GO:00300422 | Colorectum | MSS | actin filament depolymerization | 22/3467 | 59/18723 | 5.35e-04 | 6.02e-03 | 22 |
GO:00508921 | Colorectum | MSS | intestinal absorption | 17/3467 | 41/18723 | 5.48e-04 | 6.10e-03 | 17 |
GO:00514942 | Colorectum | MSS | negative regulation of cytoskeleton organization | 47/3467 | 163/18723 | 8.45e-04 | 8.71e-03 | 47 |
GO:00308342 | Colorectum | MSS | regulation of actin filament depolymerization | 20/3467 | 54/18723 | 1.04e-03 | 1.03e-02 | 20 |
GO:00226001 | Colorectum | MSS | digestive system process | 31/3467 | 104/18723 | 3.46e-03 | 2.59e-02 | 31 |
GO:00308352 | Colorectum | MSS | negative regulation of actin filament depolymerization | 16/3467 | 45/18723 | 5.12e-03 | 3.51e-02 | 16 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:00070154 | Colorectum | FAP | actin filament organization | 125/2622 | 442/18723 | 1.97e-15 | 3.03e-12 | 125 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LIMA1 | SNV | Missense_Mutation | | c.578C>A | p.Pro193Gln | p.P193Q | Q9UHB6 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
LIMA1 | SNV | Missense_Mutation | | c.772N>C | p.Glu258Gln | p.E258Q | Q9UHB6 | protein_coding | deleterious(0.01) | possibly_damaging(0.71) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
LIMA1 | SNV | Missense_Mutation | | c.2275N>A | p.Glu759Lys | p.E759K | Q9UHB6 | protein_coding | deleterious(0.02) | possibly_damaging(0.476) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
LIMA1 | SNV | Missense_Mutation | rs763276725 | c.889N>A | p.Glu297Lys | p.E297K | Q9UHB6 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIMA1 | SNV | Missense_Mutation | | c.1943A>G | p.Asn648Ser | p.N648S | Q9UHB6 | protein_coding | tolerated(1) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
LIMA1 | SNV | Missense_Mutation | | c.178N>G | p.Leu60Val | p.L60V | Q9UHB6 | protein_coding | tolerated(0.09) | benign(0.156) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
LIMA1 | SNV | Missense_Mutation | novel | c.823N>A | p.Gln275Lys | p.Q275K | Q9UHB6 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-S3-AA11-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | CR |
LIMA1 | SNV | Missense_Mutation | novel | c.1066N>T | p.Pro356Ser | p.P356S | Q9UHB6 | protein_coding | tolerated(0.3) | benign(0.01) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LIMA1 | SNV | Missense_Mutation | | c.150G>A | p.Met50Ile | p.M50I | Q9UHB6 | protein_coding | tolerated(0.49) | benign(0.023) | TCGA-C5-A1BL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LIMA1 | SNV | Missense_Mutation | rs781115938 | c.1717N>A | p.Asp573Asn | p.D573N | Q9UHB6 | protein_coding | deleterious(0.03) | probably_damaging(0.985) | TCGA-EK-A2RO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |