Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ITGB3

Gene summary for ITGB3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ITGB3

Gene ID

3690

Gene nameintegrin subunit beta 3
Gene AliasBDPLT16
Cytomap17q21.32
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

P05106


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
3690ITGB3male-WTAHumanThyroidPTC8.28e-202.61e-010.1037
3690ITGB3nodule-WTAHumanThyroidgoiters2.52e-021.85e-010.0534
3690ITGB3PTC01HumanThyroidPTC2.79e-102.45e-010.1899
3690ITGB3PTC04HumanThyroidPTC8.44e-143.76e-010.1927
3690ITGB3PTC05HumanThyroidPTC6.16e-176.14e-010.2065
3690ITGB3PTC06HumanThyroidPTC1.22e-398.10e-010.2057
3690ITGB3PTC07HumanThyroidPTC4.59e-163.12e-010.2044
3690ITGB3ATC2HumanThyroidATC1.60e-076.07e-010.34
3690ITGB3ATC4HumanThyroidATC3.76e-061.41e-010.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:009013027Thyroidgoiterstissue migration23/497365/187231.25e-043.77e-0323
GO:0016032210Thyroidgoitersviral process25/497415/187231.31e-043.92e-0325
GO:001063127Thyroidgoitersepithelial cell migration22/497357/187232.38e-046.62e-0322
GO:009013227Thyroidgoitersepithelium migration22/497360/187232.68e-047.20e-0322
GO:0019058210Thyroidgoitersviral life cycle20/497317/187233.34e-048.54e-0320
GO:005123529Thyroidgoitersmaintenance of location20/497327/187234.97e-041.20e-0220
GO:003410929Thyroidgoitershomotypic cell-cell adhesion9/49790/187236.40e-041.51e-029
GO:0052126210Thyroidgoitersmovement in host environment13/497175/187238.22e-041.79e-0213
GO:0042060210Thyroidgoiterswound healing23/497422/187239.62e-042.01e-0223
GO:000166729Thyroidgoitersameboidal-type cell migration25/497475/187239.67e-042.01e-0225
GO:0051701210Thyroidgoitersbiological process involved in interaction with host14/497203/187231.09e-032.19e-0214
GO:0046718210Thyroidgoitersviral entry into host cell11/497144/187231.62e-032.99e-0211
GO:0043112110Thyroidgoitersreceptor metabolic process12/497166/187231.63e-032.99e-0212
GO:006024918Thyroidgoitersanatomical structure homeostasis18/497314/187231.92e-033.31e-0218
GO:007052724Thyroidgoitersplatelet aggregation7/49767/187231.96e-033.32e-027
GO:000189419Thyroidgoiterstissue homeostasis16/497268/187232.24e-033.70e-0216
GO:003444626Thyroidgoiterssubstrate adhesion-dependent cell spreading9/497108/187232.33e-033.82e-029
GO:0044409210Thyroidgoitersentry into host11/497151/187232.36e-033.85e-0211
GO:004825924Thyroidgoitersregulation of receptor-mediated endocytosis9/497110/187232.64e-034.19e-029
GO:001603234ThyroidATCviral process241/6293415/187235.50e-252.04e-22241
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
FN1ITGAV_ITGB3FN1_ITGAV_ITGB3FN1THCAADJ
THBS1ITGAV_ITGB3THBS1_ITGAV_ITGB3THBSTHCAADJ
THBS2ITGAV_ITGB3THBS2_ITGAV_ITGB3THBSTHCAADJ
SPP1ITGAV_ITGB3SPP1_ITGAV_ITGB3SPP1THCAADJ
TNXBITGAV_ITGB3TNXB_ITGAV_ITGB3TENASCINTHCAADJ
PTNITGAV_ITGB3PTN_ITGAV_ITGB3PTNTHCAADJ
VWFITGAV_ITGB3VWF_ITGAV_ITGB3VWFTHCAADJ
IGF1ITGAV_ITGB3IGF1_ITGAV_ITGB3IGFTHCAADJ
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ITGB3SNVMissense_Mutationnovelc.230N>Ap.Pro77Glnp.P77QP05106protein_codingtolerated(0.59)benign(0.003)TCGA-A7-A6VY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideCR
ITGB3SNVMissense_Mutationc.1789N>Gp.Asn597Aspp.N597DP05106protein_codingtolerated(1)benign(0.029)TCGA-AR-A24H-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
ITGB3SNVMissense_Mutationc.1094A>Gp.Asn365Serp.N365SP05106protein_codingdeleterious(0.01)benign(0.122)TCGA-B6-A0X0-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ITGB3SNVMissense_Mutationc.304N>Ap.Asp102Asnp.D102NP05106protein_codingtolerated(0.71)benign(0.034)TCGA-BH-A0B8-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
ITGB3insertionFrame_Shift_Insnovelc.2216_2217insATTTp.Ile740PhefsTer17p.I740Ffs*17P05106protein_codingTCGA-A8-A06U-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ITGB3insertionNonsense_Mutationnovelc.2217_2218insTCTCTTTCTTTCTTTTGAGp.Ile740SerfsTer6p.I740Sfs*6P05106protein_codingTCGA-A8-A06U-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ITGB3insertionFrame_Shift_Insnovelc.1473_1474insGp.Trp492ValfsTer7p.W492Vfs*7P05106protein_codingTCGA-AN-A04A-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
ITGB3insertionFrame_Shift_Insnovelc.1476_1477insTGGAAAATAGTGCTTTGTGCATCTTGp.Leu493TrpfsTer185p.L493Wfs*185P05106protein_codingTCGA-AN-A04A-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
ITGB3deletionFrame_Shift_Delnovelc.1782delNp.Met594IlefsTer75p.M594Ifs*75P05106protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
ITGB3insertionFrame_Shift_Insnovelc.2352_2355dupGTACp.Arg786ValfsTer81p.R786Vfs*81P05106protein_codingTCGA-E2-A1LE-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapyherceptinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
3690ITGB3DRUGGABLE GENOME, CELL SURFACEabciximabABCIXIMAB20938371
3690ITGB3DRUGGABLE GENOME, CELL SURFACEEPTIFIBATIDEEPTIFIBATIDE
3690ITGB3DRUGGABLE GENOME, CELL SURFACEantagonistCHEMBL1743014ETARACIZUMAB
3690ITGB3DRUGGABLE GENOME, CELL SURFACEGANTOFIBANGANTOFIBAN
3690ITGB3DRUGGABLE GENOME, CELL SURFACEGLPG0187GLPG-0187
3690ITGB3DRUGGABLE GENOME, CELL SURFACEaspirinASPIRIN17184645,16458133,16675000,11723016,16493486,10704169,11054089,15840736,10459913,16153930,23834376,22028352,20138334,16581111
3690ITGB3DRUGGABLE GENOME, CELL SURFACETIROFIBANTIROFIBAN
3690ITGB3DRUGGABLE GENOME, CELL SURFACEEPTIFIBATIDEEPTIFIBATIDE
3690ITGB3DRUGGABLE GENOME, CELL SURFACECILENGITIDECILENGITIDE24095096
3690ITGB3DRUGGABLE GENOME, CELL SURFACECILENGITIDECILENGITIDE
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