![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: INF2 |
Gene summary for INF2 |
![]() |
Gene information | Species | Human | Gene symbol | INF2 | Gene ID | 64423 |
Gene name | inverted formin 2 | |
Gene Alias | C14orf151 | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0000266 | UniProtAcc | Q27J81 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64423 | INF2 | LZE2T | Human | Esophagus | ESCC | 4.43e-02 | 3.13e-01 | 0.082 |
64423 | INF2 | LZE4T | Human | Esophagus | ESCC | 1.02e-06 | 9.03e-02 | 0.0811 |
64423 | INF2 | LZE20T | Human | Esophagus | ESCC | 3.78e-02 | 9.49e-02 | 0.0662 |
64423 | INF2 | LZE24T | Human | Esophagus | ESCC | 9.01e-06 | 1.17e-01 | 0.0596 |
64423 | INF2 | P1T-E | Human | Esophagus | ESCC | 1.65e-03 | 3.92e-01 | 0.0875 |
64423 | INF2 | P2T-E | Human | Esophagus | ESCC | 3.38e-09 | 1.01e-01 | 0.1177 |
64423 | INF2 | P4T-E | Human | Esophagus | ESCC | 2.81e-19 | 3.01e-01 | 0.1323 |
64423 | INF2 | P5T-E | Human | Esophagus | ESCC | 3.17e-28 | 3.41e-01 | 0.1327 |
64423 | INF2 | P8T-E | Human | Esophagus | ESCC | 8.14e-20 | 3.71e-01 | 0.0889 |
64423 | INF2 | P9T-E | Human | Esophagus | ESCC | 3.02e-08 | 1.38e-01 | 0.1131 |
64423 | INF2 | P10T-E | Human | Esophagus | ESCC | 3.79e-36 | 5.74e-01 | 0.116 |
64423 | INF2 | P11T-E | Human | Esophagus | ESCC | 1.41e-11 | 3.88e-01 | 0.1426 |
64423 | INF2 | P12T-E | Human | Esophagus | ESCC | 3.13e-20 | 3.53e-01 | 0.1122 |
64423 | INF2 | P15T-E | Human | Esophagus | ESCC | 4.13e-29 | 5.88e-01 | 0.1149 |
64423 | INF2 | P16T-E | Human | Esophagus | ESCC | 2.12e-07 | 1.38e-01 | 0.1153 |
64423 | INF2 | P17T-E | Human | Esophagus | ESCC | 1.60e-09 | 4.32e-01 | 0.1278 |
64423 | INF2 | P19T-E | Human | Esophagus | ESCC | 5.46e-07 | 6.42e-01 | 0.1662 |
64423 | INF2 | P20T-E | Human | Esophagus | ESCC | 2.71e-15 | 3.14e-01 | 0.1124 |
64423 | INF2 | P21T-E | Human | Esophagus | ESCC | 2.33e-25 | 4.71e-01 | 0.1617 |
64423 | INF2 | P22T-E | Human | Esophagus | ESCC | 3.13e-12 | 1.93e-01 | 0.1236 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00703046 | Esophagus | ESCC | positive regulation of stress-activated protein kinase signaling cascade | 74/8552 | 128/18723 | 3.77e-03 | 1.53e-02 | 74 |
GO:00486607 | Esophagus | ESCC | regulation of smooth muscle cell proliferation | 100/8552 | 180/18723 | 4.76e-03 | 1.85e-02 | 100 |
GO:00330025 | Esophagus | ESCC | muscle cell proliferation | 134/8552 | 248/18723 | 4.80e-03 | 1.86e-02 | 134 |
GO:003103219 | Esophagus | ESCC | actomyosin structure organization | 108/8552 | 196/18723 | 4.86e-03 | 1.88e-02 | 108 |
GO:00002662 | Esophagus | ESCC | mitochondrial fission | 28/8552 | 42/18723 | 4.90e-03 | 1.89e-02 | 28 |
GO:011002025 | Esophagus | ESCC | regulation of actomyosin structure organization | 59/8552 | 100/18723 | 4.98e-03 | 1.91e-02 | 59 |
GO:00486615 | Esophagus | ESCC | positive regulation of smooth muscle cell proliferation | 61/8552 | 104/18723 | 5.22e-03 | 1.97e-02 | 61 |
GO:0006471 | Esophagus | ESCC | protein ADP-ribosylation | 24/8552 | 35/18723 | 5.25e-03 | 1.97e-02 | 24 |
GO:00322052 | Esophagus | ESCC | negative regulation of telomere maintenance | 24/8552 | 35/18723 | 5.25e-03 | 1.97e-02 | 24 |
GO:190303420 | Esophagus | ESCC | regulation of response to wounding | 93/8552 | 167/18723 | 5.77e-03 | 2.14e-02 | 93 |
GO:00328745 | Esophagus | ESCC | positive regulation of stress-activated MAPK cascade | 72/8552 | 126/18723 | 6.24e-03 | 2.29e-02 | 72 |
GO:001046620 | Esophagus | ESCC | negative regulation of peptidase activity | 140/8552 | 262/18723 | 6.73e-03 | 2.46e-02 | 140 |
GO:001095119 | Esophagus | ESCC | negative regulation of endopeptidase activity | 135/8552 | 252/18723 | 6.86e-03 | 2.51e-02 | 135 |
GO:005149610 | Esophagus | ESCC | positive regulation of stress fiber assembly | 33/8552 | 52/18723 | 7.38e-03 | 2.65e-02 | 33 |
GO:001095511 | Esophagus | ESCC | negative regulation of protein processing | 20/8552 | 29/18723 | 9.66e-03 | 3.34e-02 | 20 |
GO:190331811 | Esophagus | ESCC | negative regulation of protein maturation | 20/8552 | 29/18723 | 9.66e-03 | 3.34e-02 | 20 |
GO:00463302 | Esophagus | ESCC | positive regulation of JNK cascade | 52/8552 | 89/18723 | 1.04e-02 | 3.56e-02 | 52 |
GO:190303617 | Esophagus | ESCC | positive regulation of response to wounding | 43/8552 | 72/18723 | 1.14e-02 | 3.84e-02 | 43 |
GO:009030310 | Esophagus | ESCC | positive regulation of wound healing | 36/8552 | 59/18723 | 1.27e-02 | 4.21e-02 | 36 |
GO:00610417 | Liver | NAFLD | regulation of wound healing | 39/1882 | 134/18723 | 5.52e-10 | 1.28e-07 | 39 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INF2 | SNV | Missense_Mutation | novel | c.2173N>A | p.Glu725Lys | p.E725K | Q27J81 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
INF2 | SNV | Missense_Mutation | c.571G>A | p.Val191Met | p.V191M | Q27J81 | protein_coding | deleterious(0.01) | probably_damaging(0.975) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
INF2 | SNV | Missense_Mutation | c.1960N>A | p.Glu654Lys | p.E654K | Q27J81 | protein_coding | deleterious(0) | possibly_damaging(0.871) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
INF2 | deletion | Frame_Shift_Del | novel | c.2256delN | p.Gln753SerfsTer8 | p.Q753Sfs*8 | Q27J81 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
INF2 | SNV | Missense_Mutation | novel | c.3022N>T | p.Pro1008Ser | p.P1008S | Q27J81 | protein_coding | tolerated_low_confidence(0.2) | benign(0.001) | TCGA-DS-A5RQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
INF2 | SNV | Missense_Mutation | c.2619N>G | p.Ile873Met | p.I873M | Q27J81 | protein_coding | deleterious(0.04) | possibly_damaging(0.5) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
INF2 | SNV | Missense_Mutation | rs752180110 | c.2789N>A | p.Arg930Gln | p.R930Q | Q27J81 | protein_coding | deleterious(0) | possibly_damaging(0.806) | TCGA-A6-2679-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INF2 | SNV | Missense_Mutation | rs771072587 | c.2041N>A | p.Glu681Lys | p.E681K | Q27J81 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
INF2 | SNV | Missense_Mutation | c.2356N>A | p.Leu786Met | p.L786M | Q27J81 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INF2 | SNV | Missense_Mutation | c.319G>A | p.Ala107Thr | p.A107T | Q27J81 | protein_coding | tolerated(0.07) | probably_damaging(0.975) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |