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Gene: IFT88 |
Gene summary for IFT88 |
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Gene information | Species | Human | Gene symbol | IFT88 | Gene ID | 8100 |
Gene name | intraflagellar transport 88 | |
Gene Alias | D13S1056E | |
Cytomap | 13q12.11 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | B3KX42 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8100 | IFT88 | NAFLD1 | Human | Liver | NAFLD | 7.76e-06 | 8.93e-01 | -0.04 |
8100 | IFT88 | S43 | Human | Liver | Cirrhotic | 1.16e-05 | -1.41e-01 | -0.0187 |
8100 | IFT88 | HCC1_Meng | Human | Liver | HCC | 1.92e-32 | -1.25e-01 | 0.0246 |
8100 | IFT88 | HCC2_Meng | Human | Liver | HCC | 1.51e-18 | -6.05e-02 | 0.0107 |
8100 | IFT88 | HCC2 | Human | Liver | HCC | 4.68e-08 | 3.47e+00 | 0.5341 |
8100 | IFT88 | Pt13.a | Human | Liver | HCC | 2.53e-02 | -1.92e-01 | 0.021 |
8100 | IFT88 | S028 | Human | Liver | HCC | 1.78e-02 | 3.83e-01 | 0.2503 |
8100 | IFT88 | S029 | Human | Liver | HCC | 8.39e-03 | 4.49e-01 | 0.2581 |
8100 | IFT88 | HTA12-23-1 | Human | Pancreas | PDAC | 4.93e-04 | 6.06e-01 | 0.3405 |
8100 | IFT88 | HTA12-26-1 | Human | Pancreas | PDAC | 1.35e-17 | 7.64e-01 | 0.3728 |
8100 | IFT88 | HTA12-29-1 | Human | Pancreas | PDAC | 2.56e-18 | 5.14e-01 | 0.3722 |
8100 | IFT88 | male-WTA | Human | Thyroid | PTC | 2.77e-13 | 6.72e-02 | 0.1037 |
8100 | IFT88 | PTC01 | Human | Thyroid | PTC | 5.39e-11 | 1.76e-01 | 0.1899 |
8100 | IFT88 | PTC03 | Human | Thyroid | PTC | 1.31e-05 | 1.06e-01 | 0.1784 |
8100 | IFT88 | PTC04 | Human | Thyroid | PTC | 2.13e-14 | 1.89e-01 | 0.1927 |
8100 | IFT88 | PTC05 | Human | Thyroid | PTC | 1.66e-16 | 3.20e-01 | 0.2065 |
8100 | IFT88 | PTC06 | Human | Thyroid | PTC | 1.53e-21 | 4.55e-01 | 0.2057 |
8100 | IFT88 | PTC07 | Human | Thyroid | PTC | 3.42e-31 | 4.20e-01 | 0.2044 |
8100 | IFT88 | ATC09 | Human | Thyroid | ATC | 4.83e-03 | 8.04e-02 | 0.2871 |
8100 | IFT88 | ATC13 | Human | Thyroid | ATC | 2.19e-27 | 4.91e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004408813 | Thyroid | ATC | regulation of vacuole organization | 26/6293 | 45/18723 | 7.43e-04 | 4.14e-03 | 26 |
GO:200078513 | Thyroid | ATC | regulation of autophagosome assembly | 21/6293 | 39/18723 | 7.26e-03 | 2.86e-02 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFT88 | SNV | Missense_Mutation | c.767N>T | p.Arg256Ile | p.R256I | Q13099 | protein_coding | tolerated(0.05) | possibly_damaging(0.69) | TCGA-A2-A0CM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD | |
IFT88 | SNV | Missense_Mutation | c.1796N>T | p.Ser599Phe | p.S599F | Q13099 | protein_coding | tolerated(0.27) | benign(0.276) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
IFT88 | SNV | Missense_Mutation | c.1020N>C | p.Leu340Phe | p.L340F | Q13099 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IFT88 | SNV | Missense_Mutation | c.243N>T | p.Lys81Asn | p.K81N | Q13099 | protein_coding | tolerated(0.44) | benign(0.272) | TCGA-C8-A12W-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
IFT88 | SNV | Missense_Mutation | c.1420G>C | p.Asp474His | p.D474H | Q13099 | protein_coding | deleterious(0) | possibly_damaging(0.498) | TCGA-E2-A14V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
IFT88 | SNV | Missense_Mutation | c.1722N>A | p.Met574Ile | p.M574I | Q13099 | protein_coding | tolerated(0.3) | benign(0.06) | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
IFT88 | insertion | Nonsense_Mutation | novel | c.2376_2377insTAAGAACCTACAGTTAAGAAAAAGTATGCATGC | p.Glu792_Ile793insTer | p.E792_I793ins* | Q13099 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
IFT88 | SNV | Missense_Mutation | novel | c.1358A>G | p.Lys453Arg | p.K453R | Q13099 | protein_coding | tolerated(0.17) | probably_damaging(0.98) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
IFT88 | SNV | Missense_Mutation | novel | c.1367N>C | p.Arg456Thr | p.R456T | Q13099 | protein_coding | deleterious(0.05) | benign(0.115) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
IFT88 | SNV | Missense_Mutation | c.1366A>G | p.Arg456Gly | p.R456G | Q13099 | protein_coding | deleterious(0.01) | benign(0.079) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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