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Gene: IFITM1 |
Gene summary for IFITM1 |
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Gene information | Species | Human | Gene symbol | IFITM1 | Gene ID | 8519 |
Gene name | interferon induced transmembrane protein 1 | |
Gene Alias | 9-27 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | A0A024R210 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8519 | IFITM1 | GSM4909287 | Human | Breast | IDC | 3.28e-08 | 3.84e-01 | 0.2057 |
8519 | IFITM1 | GSM4909296 | Human | Breast | IDC | 1.06e-18 | 5.98e-01 | 0.1524 |
8519 | IFITM1 | GSM4909300 | Human | Breast | IDC | 3.75e-06 | 4.69e-01 | 0.0334 |
8519 | IFITM1 | GSM4909301 | Human | Breast | IDC | 1.84e-16 | 5.68e-01 | 0.1577 |
8519 | IFITM1 | GSM4909302 | Human | Breast | IDC | 1.02e-12 | 4.71e-01 | 0.1545 |
8519 | IFITM1 | GSM4909305 | Human | Breast | IDC | 3.33e-19 | 6.03e-01 | 0.0436 |
8519 | IFITM1 | GSM4909306 | Human | Breast | IDC | 8.19e-30 | 6.26e-01 | 0.1564 |
8519 | IFITM1 | GSM4909307 | Human | Breast | IDC | 3.46e-48 | 9.19e-01 | 0.1569 |
8519 | IFITM1 | GSM4909308 | Human | Breast | IDC | 5.15e-43 | 8.44e-01 | 0.158 |
8519 | IFITM1 | GSM4909309 | Human | Breast | IDC | 1.16e-73 | 1.42e+00 | 0.0483 |
8519 | IFITM1 | GSM4909311 | Human | Breast | IDC | 4.30e-02 | 6.67e-02 | 0.1534 |
8519 | IFITM1 | GSM4909319 | Human | Breast | IDC | 2.30e-36 | 6.82e-01 | 0.1563 |
8519 | IFITM1 | GSM4909320 | Human | Breast | IDC | 4.04e-15 | 8.45e-01 | 0.1575 |
8519 | IFITM1 | GSM4909321 | Human | Breast | IDC | 9.23e-17 | 5.49e-01 | 0.1559 |
8519 | IFITM1 | brca2 | Human | Breast | Precancer | 3.36e-14 | 4.71e-01 | -0.024 |
8519 | IFITM1 | P3 | Human | Breast | IDC | 4.35e-02 | 4.97e-01 | 0.1542 |
8519 | IFITM1 | AEH-subject1 | Human | Endometrium | AEH | 4.22e-04 | -2.76e-01 | -0.3059 |
8519 | IFITM1 | AEH-subject2 | Human | Endometrium | AEH | 3.21e-15 | -4.23e-01 | -0.2525 |
8519 | IFITM1 | AEH-subject3 | Human | Endometrium | AEH | 8.61e-11 | -3.89e-01 | -0.2576 |
8519 | IFITM1 | AEH-subject4 | Human | Endometrium | AEH | 2.53e-06 | -2.67e-01 | -0.2657 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20001464 | Endometrium | AEH | negative regulation of cell motility | 67/2100 | 359/18723 | 1.86e-05 | 3.77e-04 | 67 |
GO:00512714 | Endometrium | AEH | negative regulation of cellular component movement | 68/2100 | 367/18723 | 2.06e-05 | 4.11e-04 | 68 |
GO:00450699 | Endometrium | AEH | regulation of viral genome replication | 23/2100 | 85/18723 | 4.25e-05 | 7.20e-04 | 23 |
GO:00400134 | Endometrium | AEH | negative regulation of locomotion | 70/2100 | 391/18723 | 4.95e-05 | 8.05e-04 | 70 |
GO:004390315 | Endometrium | AEH | regulation of biological process involved in symbiotic interaction | 19/2100 | 72/18723 | 2.74e-04 | 3.14e-03 | 19 |
GO:00096159 | Endometrium | AEH | response to virus | 63/2100 | 367/18723 | 3.81e-04 | 4.10e-03 | 63 |
GO:00523729 | Endometrium | AEH | modulation by symbiont of entry into host | 14/2100 | 49/18723 | 7.19e-04 | 6.90e-03 | 14 |
GO:00485257 | Endometrium | AEH | negative regulation of viral process | 21/2100 | 92/18723 | 1.10e-03 | 9.61e-03 | 21 |
GO:00456672 | Endometrium | AEH | regulation of osteoblast differentiation | 27/2100 | 132/18723 | 1.40e-03 | 1.18e-02 | 27 |
GO:00465966 | Endometrium | AEH | regulation of viral entry into host cell | 12/2100 | 42/18723 | 1.70e-03 | 1.37e-02 | 12 |
GO:00450715 | Endometrium | AEH | negative regulation of viral genome replication | 14/2100 | 56/18723 | 2.92e-03 | 2.08e-02 | 14 |
GO:00456692 | Endometrium | AEH | positive regulation of osteoblast differentiation | 16/2100 | 69/18723 | 3.46e-03 | 2.39e-02 | 16 |
GO:19039016 | Endometrium | AEH | negative regulation of viral life cycle | 8/2100 | 25/18723 | 4.62e-03 | 2.96e-02 | 8 |
GO:001603217 | Endometrium | EEC | viral process | 112/2168 | 415/18723 | 2.48e-18 | 1.35e-15 | 112 |
GO:001905817 | Endometrium | EEC | viral life cycle | 86/2168 | 317/18723 | 1.63e-14 | 4.65e-12 | 86 |
GO:004440317 | Endometrium | EEC | biological process involved in symbiotic interaction | 73/2168 | 290/18723 | 7.47e-11 | 9.95e-09 | 73 |
GO:001907917 | Endometrium | EEC | viral genome replication | 42/2168 | 131/18723 | 3.43e-10 | 3.61e-08 | 42 |
GO:005170117 | Endometrium | EEC | biological process involved in interaction with host | 54/2168 | 203/18723 | 2.67e-09 | 2.01e-07 | 54 |
GO:005212617 | Endometrium | EEC | movement in host environment | 47/2168 | 175/18723 | 2.03e-08 | 1.23e-06 | 47 |
GO:000164914 | Endometrium | EEC | osteoblast differentiation | 53/2168 | 229/18723 | 5.32e-07 | 2.02e-05 | 53 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04662 | Oral cavity | OSCC | B cell receptor signaling pathway | 48/3704 | 84/8465 | 9.02e-03 | 2.01e-02 | 1.03e-02 | 48 |
hsa046621 | Oral cavity | OSCC | B cell receptor signaling pathway | 48/3704 | 84/8465 | 9.02e-03 | 2.01e-02 | 1.03e-02 | 48 |
hsa046622 | Oral cavity | EOLP | B cell receptor signaling pathway | 29/1218 | 84/8465 | 2.75e-06 | 2.11e-05 | 1.25e-05 | 29 |
hsa046623 | Oral cavity | EOLP | B cell receptor signaling pathway | 29/1218 | 84/8465 | 2.75e-06 | 2.11e-05 | 1.25e-05 | 29 |
hsa046624 | Oral cavity | NEOLP | B cell receptor signaling pathway | 19/1112 | 84/8465 | 1.13e-02 | 3.72e-02 | 2.34e-02 | 19 |
hsa046625 | Oral cavity | NEOLP | B cell receptor signaling pathway | 19/1112 | 84/8465 | 1.13e-02 | 3.72e-02 | 2.34e-02 | 19 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFITM1 | SNV | Missense_Mutation | c.26N>G | p.Ala9Gly | p.A9G | P13164 | protein_coding | tolerated(0.17) | benign(0.14) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IFITM1 | SNV | Missense_Mutation | c.59N>T | p.Pro20Leu | p.P20L | P13164 | protein_coding | tolerated(0.42) | benign(0.02) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IFITM1 | deletion | Frame_Shift_Del | c.45delC | p.Ser16AlafsTer9 | p.S16Afs*9 | P13164 | protein_coding | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
IFITM1 | SNV | Missense_Mutation | novel | c.23N>C | p.Val8Ala | p.V8A | P13164 | protein_coding | tolerated(0.06) | benign(0.259) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IFITM1 | SNV | Missense_Mutation | rs758516594 | c.52N>G | p.Ile18Val | p.I18V | P13164 | protein_coding | tolerated(0.16) | benign(0.001) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IFITM1 | SNV | Missense_Mutation | rs372454990 | c.319G>A | p.Gly107Ser | p.G107S | P13164 | protein_coding | tolerated(0.2) | benign(0.013) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IFITM1 | deletion | In_Frame_Del | novel | c.31_48delNNNNNNNNNNNNNNNNNN | p.Leu11_Ser16del | p.L11_S16del | P13164 | protein_coding | TCGA-ES-A2HS-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
IFITM1 | SNV | Missense_Mutation | novel | c.119C>A | p.Ser40Tyr | p.S40Y | P13164 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-43-2576-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
IFITM1 | SNV | Missense_Mutation | c.10G>A | p.Glu4Lys | p.E4K | P13164 | protein_coding | deleterious(0.02) | benign(0.178) | TCGA-66-2757-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | gemcitabine | PD | |
IFITM1 | SNV | Missense_Mutation | novel | c.197N>A | p.Arg66Lys | p.R66K | P13164 | protein_coding | deleterious(0.02) | benign(0.364) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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