![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: HOOK1 |
Gene summary for HOOK1 |
![]() |
Gene information | Species | Human | Gene symbol | HOOK1 | Gene ID | 51361 |
Gene name | hook microtubule tethering protein 1 | |
Gene Alias | HK1 | |
Cytomap | 1p32.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9UJC3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51361 | HOOK1 | LZE4T | Human | Esophagus | ESCC | 3.49e-03 | -2.73e-02 | 0.0811 |
51361 | HOOK1 | LZE20T | Human | Esophagus | ESCC | 3.92e-06 | 1.23e-01 | 0.0662 |
51361 | HOOK1 | LZE24T | Human | Esophagus | ESCC | 1.91e-20 | 3.15e-01 | 0.0596 |
51361 | HOOK1 | P1T-E | Human | Esophagus | ESCC | 7.72e-07 | 2.78e-01 | 0.0875 |
51361 | HOOK1 | P2T-E | Human | Esophagus | ESCC | 4.13e-21 | 3.12e-01 | 0.1177 |
51361 | HOOK1 | P4T-E | Human | Esophagus | ESCC | 5.08e-11 | 2.18e-01 | 0.1323 |
51361 | HOOK1 | P5T-E | Human | Esophagus | ESCC | 7.93e-14 | 1.85e-01 | 0.1327 |
51361 | HOOK1 | P8T-E | Human | Esophagus | ESCC | 6.07e-15 | 1.91e-01 | 0.0889 |
51361 | HOOK1 | P9T-E | Human | Esophagus | ESCC | 4.16e-03 | -7.50e-02 | 0.1131 |
51361 | HOOK1 | P10T-E | Human | Esophagus | ESCC | 2.56e-02 | -4.17e-02 | 0.116 |
51361 | HOOK1 | P12T-E | Human | Esophagus | ESCC | 4.50e-15 | 4.16e-01 | 0.1122 |
51361 | HOOK1 | P15T-E | Human | Esophagus | ESCC | 6.93e-05 | 6.71e-02 | 0.1149 |
51361 | HOOK1 | P16T-E | Human | Esophagus | ESCC | 9.20e-10 | 3.81e-02 | 0.1153 |
51361 | HOOK1 | P20T-E | Human | Esophagus | ESCC | 4.30e-19 | 5.37e-01 | 0.1124 |
51361 | HOOK1 | P21T-E | Human | Esophagus | ESCC | 6.60e-03 | -9.40e-02 | 0.1617 |
51361 | HOOK1 | P22T-E | Human | Esophagus | ESCC | 2.65e-08 | -7.53e-02 | 0.1236 |
51361 | HOOK1 | P23T-E | Human | Esophagus | ESCC | 7.77e-17 | 4.13e-01 | 0.108 |
51361 | HOOK1 | P24T-E | Human | Esophagus | ESCC | 3.36e-07 | 3.87e-02 | 0.1287 |
51361 | HOOK1 | P26T-E | Human | Esophagus | ESCC | 5.17e-18 | 3.69e-01 | 0.1276 |
51361 | HOOK1 | P27T-E | Human | Esophagus | ESCC | 2.24e-42 | 9.96e-01 | 0.1055 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000704115 | Thyroid | PTC | lysosomal transport | 63/5968 | 114/18723 | 1.97e-07 | 3.54e-06 | 63 |
GO:000703210 | Thyroid | PTC | endosome organization | 48/5968 | 82/18723 | 5.65e-07 | 9.04e-06 | 48 |
GO:000703010 | Thyroid | PTC | Golgi organization | 79/5968 | 157/18723 | 1.11e-06 | 1.64e-05 | 79 |
GO:00311229 | Thyroid | PTC | cytoplasmic microtubule organization | 34/5968 | 56/18723 | 8.20e-06 | 9.42e-05 | 34 |
GO:00070405 | Thyroid | PTC | lysosome organization | 38/5968 | 74/18723 | 3.84e-04 | 2.58e-03 | 38 |
GO:00801715 | Thyroid | PTC | lytic vacuole organization | 38/5968 | 74/18723 | 3.84e-04 | 2.58e-03 | 38 |
GO:00083335 | Thyroid | PTC | endosome to lysosome transport | 29/5968 | 55/18723 | 1.06e-03 | 6.28e-03 | 29 |
GO:00450228 | Thyroid | PTC | early endosome to late endosome transport | 22/5968 | 40/18723 | 2.05e-03 | 1.09e-02 | 22 |
GO:009892710 | Thyroid | PTC | vesicle-mediated transport between endosomal compartments | 23/5968 | 43/18723 | 2.66e-03 | 1.35e-02 | 23 |
GO:001605023 | Thyroid | ATC | vesicle organization | 166/6293 | 300/18723 | 6.14e-15 | 3.92e-13 | 166 |
GO:000703322 | Thyroid | ATC | vacuole organization | 100/6293 | 180/18723 | 1.07e-09 | 2.71e-08 | 100 |
GO:000703423 | Thyroid | ATC | vacuolar transport | 89/6293 | 157/18723 | 2.26e-09 | 5.40e-08 | 89 |
GO:003070532 | Thyroid | ATC | cytoskeleton-dependent intracellular transport | 105/6293 | 195/18723 | 4.31e-09 | 9.70e-08 | 105 |
GO:001648218 | Thyroid | ATC | cytosolic transport | 93/6293 | 168/18723 | 5.19e-09 | 1.15e-07 | 93 |
GO:000704116 | Thyroid | ATC | lysosomal transport | 63/6293 | 114/18723 | 1.58e-06 | 1.93e-05 | 63 |
GO:000703216 | Thyroid | ATC | endosome organization | 48/6293 | 82/18723 | 3.13e-06 | 3.56e-05 | 48 |
GO:000703015 | Thyroid | ATC | Golgi organization | 79/6293 | 157/18723 | 1.07e-05 | 1.05e-04 | 79 |
GO:003112215 | Thyroid | ATC | cytoplasmic microtubule organization | 34/6293 | 56/18723 | 2.92e-05 | 2.45e-04 | 34 |
GO:000704012 | Thyroid | ATC | lysosome organization | 39/6293 | 74/18723 | 5.41e-04 | 3.13e-03 | 39 |
GO:008017112 | Thyroid | ATC | lytic vacuole organization | 39/6293 | 74/18723 | 5.41e-04 | 3.13e-03 | 39 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOOK1 | SNV | Missense_Mutation | novel | c.436N>A | p.Glu146Lys | p.E146K | Q9UJC3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
HOOK1 | SNV | Missense_Mutation | novel | c.97G>T | p.Asp33Tyr | p.D33Y | Q9UJC3 | protein_coding | deleterious(0) | possibly_damaging(0.616) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOOK1 | SNV | Missense_Mutation | rs367708992 | c.850G>A | p.Glu284Lys | p.E284K | Q9UJC3 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOOK1 | SNV | Missense_Mutation | c.1261G>C | p.Asp421His | p.D421H | Q9UJC3 | protein_coding | deleterious(0.02) | possibly_damaging(0.795) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
HOOK1 | SNV | Missense_Mutation | c.1951N>A | p.Glu651Lys | p.E651K | Q9UJC3 | protein_coding | deleterious(0.01) | possibly_damaging(0.826) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
HOOK1 | SNV | Missense_Mutation | rs746529091 | c.1621N>A | p.Glu541Lys | p.E541K | Q9UJC3 | protein_coding | tolerated(0.25) | benign(0.167) | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
HOOK1 | SNV | Missense_Mutation | c.213N>C | p.Trp71Cys | p.W71C | Q9UJC3 | protein_coding | deleterious(0.02) | benign(0.146) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HOOK1 | SNV | Missense_Mutation | c.598A>G | p.Arg200Gly | p.R200G | Q9UJC3 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-EW-A1PH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
HOOK1 | SNV | Missense_Mutation | novel | c.868N>C | p.Asp290His | p.D290H | Q9UJC3 | protein_coding | deleterious(0.04) | benign(0.178) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
HOOK1 | SNV | Missense_Mutation | rs370424578 | c.2105N>A | p.Arg702Gln | p.R702Q | Q9UJC3 | protein_coding | tolerated(1) | benign(0.021) | TCGA-C5-A905-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |