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Gene: HNRNPH1 |
Gene summary for HNRNPH1 |
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Gene information | Species | Human | Gene symbol | HNRNPH1 | Gene ID | 3187 |
Gene name | heterogeneous nuclear ribonucleoprotein H1 | |
Gene Alias | HNRPH | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P31943 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3187 | HNRNPH1 | GSM4909285 | Human | Breast | IDC | 1.81e-06 | -3.55e-01 | 0.21 |
3187 | HNRNPH1 | GSM4909286 | Human | Breast | IDC | 1.06e-05 | -2.92e-01 | 0.1081 |
3187 | HNRNPH1 | GSM4909296 | Human | Breast | IDC | 4.24e-15 | -4.56e-01 | 0.1524 |
3187 | HNRNPH1 | GSM4909297 | Human | Breast | IDC | 2.06e-44 | 7.55e-01 | 0.1517 |
3187 | HNRNPH1 | GSM4909298 | Human | Breast | IDC | 1.76e-02 | 2.41e-01 | 0.1551 |
3187 | HNRNPH1 | GSM4909306 | Human | Breast | IDC | 1.06e-04 | -3.75e-01 | 0.1564 |
3187 | HNRNPH1 | GSM4909311 | Human | Breast | IDC | 6.97e-34 | -4.41e-01 | 0.1534 |
3187 | HNRNPH1 | GSM4909312 | Human | Breast | IDC | 3.23e-09 | -3.16e-01 | 0.1552 |
3187 | HNRNPH1 | GSM4909316 | Human | Breast | IDC | 3.75e-02 | -5.27e-01 | 0.21 |
3187 | HNRNPH1 | GSM4909317 | Human | Breast | IDC | 2.32e-02 | 2.12e-02 | 0.1355 |
3187 | HNRNPH1 | GSM4909319 | Human | Breast | IDC | 3.04e-42 | -7.68e-01 | 0.1563 |
3187 | HNRNPH1 | GSM4909320 | Human | Breast | IDC | 1.86e-06 | -5.52e-01 | 0.1575 |
3187 | HNRNPH1 | GSM4909321 | Human | Breast | IDC | 1.52e-10 | -1.24e-01 | 0.1559 |
3187 | HNRNPH1 | brca1 | Human | Breast | Precancer | 7.37e-17 | -5.94e-01 | -0.0338 |
3187 | HNRNPH1 | brca3 | Human | Breast | Precancer | 1.68e-03 | -1.99e-01 | -0.0263 |
3187 | HNRNPH1 | brca10 | Human | Breast | Precancer | 1.02e-06 | -4.73e-01 | -0.0029 |
3187 | HNRNPH1 | NCCBC14 | Human | Breast | DCIS | 4.81e-08 | -2.68e-01 | 0.2021 |
3187 | HNRNPH1 | NCCBC5 | Human | Breast | DCIS | 2.05e-09 | -2.03e-01 | 0.2046 |
3187 | HNRNPH1 | P1 | Human | Breast | IDC | 1.57e-16 | -5.90e-02 | 0.1527 |
3187 | HNRNPH1 | DCIS2 | Human | Breast | DCIS | 3.83e-71 | 9.00e-02 | 0.0085 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000039820 | Esophagus | HGIN | mRNA splicing, via spliceosome | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:004348427 | Esophagus | HGIN | regulation of RNA splicing | 59/2587 | 148/18723 | 3.61e-15 | 7.22e-13 | 59 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0043484111 | Esophagus | ESCC | regulation of RNA splicing | 116/8552 | 148/18723 | 3.18e-16 | 2.38e-14 | 116 |
GO:00434847 | Liver | NAFLD | regulation of RNA splicing | 35/1882 | 148/18723 | 1.14e-06 | 5.55e-05 | 35 |
GO:00083807 | Liver | NAFLD | RNA splicing | 70/1882 | 434/18723 | 4.62e-05 | 1.10e-03 | 70 |
GO:00003777 | Liver | NAFLD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1882 | 320/18723 | 6.21e-04 | 8.18e-03 | 51 |
GO:00003987 | Liver | NAFLD | mRNA splicing, via spliceosome | 51/1882 | 320/18723 | 6.21e-04 | 8.18e-03 | 51 |
GO:00003757 | Liver | NAFLD | RNA splicing, via transesterification reactions | 51/1882 | 324/18723 | 8.28e-04 | 1.02e-02 | 51 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
GO:000037712 | Liver | Cirrhotic | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:000039812 | Liver | Cirrhotic | mRNA splicing, via spliceosome | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:004348412 | Liver | Cirrhotic | regulation of RNA splicing | 85/4634 | 148/18723 | 2.03e-17 | 2.83e-15 | 85 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPH1 | SNV | Missense_Mutation | c.1196N>A | p.Gly399Asp | p.G399D | P31943 | protein_coding | tolerated(0.06) | benign(0.188) | TCGA-C8-A135-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
HNRNPH1 | SNV | Missense_Mutation | novel | c.1114N>A | p.Tyr372Asn | p.Y372N | P31943 | protein_coding | tolerated(0.11) | benign(0) | TCGA-E2-A15O-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | PD |
HNRNPH1 | insertion | Nonsense_Mutation | novel | c.1179_1180insCTCTGGCTTGGCAGTTGAGGCTGTTGCG | p.Ser394LeufsTer6 | p.S394Lfs*6 | P31943 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
HNRNPH1 | SNV | Missense_Mutation | c.617G>A | p.Arg206Gln | p.R206Q | P31943 | protein_coding | tolerated(0.09) | benign(0.014) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HNRNPH1 | SNV | Missense_Mutation | novel | c.1327N>A | p.Asp443Asn | p.D443N | P31943 | protein_coding | tolerated_low_confidence(0.59) | benign(0) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
HNRNPH1 | SNV | Missense_Mutation | c.16G>A | p.Glu6Lys | p.E6K | P31943 | protein_coding | tolerated(0.06) | benign(0.024) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
HNRNPH1 | SNV | Missense_Mutation | novel | c.1103G>T | p.Ser368Ile | p.S368I | P31943 | protein_coding | deleterious(0.04) | benign(0.208) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
HNRNPH1 | SNV | Missense_Mutation | c.616C>T | p.Arg206Trp | p.R206W | P31943 | protein_coding | tolerated(0.05) | benign(0.02) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HNRNPH1 | SNV | Missense_Mutation | novel | c.211N>A | p.Leu71Met | p.L71M | P31943 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HNRNPH1 | SNV | Missense_Mutation | c.1188N>T | p.Met396Ile | p.M396I | P31943 | protein_coding | tolerated(0.69) | benign(0.104) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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